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Neuroimmunological Disorders: Mechanisms and Therapies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 359

Special Issue Editors


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Guest Editor
Multiple Sclerosis Center, AHEPA, 2nd Neurological University Department, General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: neuroimmunology; neurodegenerative diseases; multiple sclerosis; neuroimaging; biomarkers; cognitive neuropsychology
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Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to this Special Issue “Neuroimmunological Disorders: Mechanisms and Therapies”.

Over the last few years, extensive research has revealed many aspects of the underlying mechanisms that contribute to the pathology of neuroimmunological diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, Mog-associated disease, and myasthenia gravis, as well as neuroinflammatory conditions attributed to therapeutic interventions such as checkpoint inhibitors. Following these discoveries, novel agents such as complement and fcrn inhibitors have been introduced in clinical practice, while others such as tyrosine kinase inhibitors and CAR-T cell therapies are currently under investigation as potential therapeutic targets. Due to the rarity of some of these conditions, current research is focused on the discovery and implementation of biomarkers and digital tools that may help us identify these conditions as early as possible and predict disease course. In addition, more epidemiological data are needed in order to produce guidelines and health policies with regard to these conditions. 

This Special Issue of the Journal of Clinical Medicine seeks commentaries, original research, and reviews focusing on advances in the research, diagnosis, monitoring, and treatment of neuroimmunological disorders and aims to provide insights about advances in the research of underlying mechanisms, current prevalence and future treatment options in neuroimmunological and neuroinflammatory disorders.

Dr. Christos Bakirtzis
Dr. Marina Kleopatra Boziki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroinflammatory
  • multiple sclerosis
  • neuromyelitis optica spectrum disorders
  • mog associated disease
  • autoimmune/paraneoplastic encephalitis
 

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Published Papers (1 paper)

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Research

10 pages, 1074 KB  
Article
Prescription Drug Use in NMOSD: A Population-Based Study in Greece with Estimation of National Disease Administrative Prevalence
by Christos Bakirtzis, Natalia Konstantinidou, Sotiria Stavropoulou De Lorenzo, Nikolaos Mitsoudis, Theodoros Moysiadis, Dimitrios Parisis, Marina Kleopatra Boziki, Orhan Aktas and Nikolaos Grigoriadis
J. Clin. Med. 2025, 14(24), 8665; https://doi.org/10.3390/jcm14248665 - 7 Dec 2025
Viewed by 274
Abstract
Background/Objectives: Neuromyelitis Optica Spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system with a globally heterogeneous prevalence/ To estimate the prescription-based prevalence of NMOSD in Greece and determine the use of long-term immunotherapies and concomitant medications in these [...] Read more.
Background/Objectives: Neuromyelitis Optica Spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system with a globally heterogeneous prevalence/ To estimate the prescription-based prevalence of NMOSD in Greece and determine the use of long-term immunotherapies and concomitant medications in these patients. Methods: We analyzed anonymized prescription records from the national prescription database, dating from 1 January 2017 to 1 May 2024. The administrative point prevalence of NMOSD in Greece on 1 January 2022 was calculated according to the national census conducted in late 2021. Results: We identified 219 cases of NMOSD and a 1:6.8 male-to-female ratio. The point prevalence on 1 January 2022 was 1.97 per 100,000, with the highest detected in the region of Crete, and the lowest in the regions of Eastern Macedonia and Thrace. The mean age of people with NMOSD on that date was 51.3 years old. Azathioprine was the most frequently prescribed maintenance immunotherapy, while antidepressants were the most common concomitant medications prescribed. Polypharmacy was observed in 28.9% of the identified cases. Conclusions: We hereby present the prescription drug use of people with NMOSD in Greece in the era just before the introduction of NMOSD-specific immunotherapy in Greece. Full article
(This article belongs to the Special Issue Neuroimmunological Disorders: Mechanisms and Therapies)
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