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Advanced Endoscopy and Imaging in Gastrointestinal Diseases
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Advanced Endoscopy and Imaging in Gastrointestinal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 1562

Special Issue Editors

Dr. Iancu Dana Monica

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Guest Editor
Anatomy and Embryology Department, “Iuliu Haåieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: gastroenterology and hepatology; oncologic surgery; minimaly invasive surgery; hepato-bilio-pancreatic surgery; advanced imaging techniques
Dr. Paul-Andrei Ștefan

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Guest Editor
Anatomy and Embryology Department, “Iuliu Haåieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: MRI; CT; artificial intelligence; imaging diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, “Advanced Endoscopy and Imaging in Gastrointestinal Diseases”, aims to bring together recent developments in endoscopic techniques and imaging technologies that are shaping the future of gastroenterology and gastrointestinal surgery. Over the past decade, advances in high-definition endoscopy, enhanced imaging techniques, and minimally invasive interventions have significantly expanded our ability to detect early pathological changes, improve diagnostic accuracy, and guide targeted therapies. These innovations allow for more precise lesion characterization, facilitate early intervention, reduce the need for more invasive procedures, guide you better in surgeries, and ultimately enhance patient safety and recovery.

Beyond diagnosis, advanced endoscopic approaches are increasingly applied in therapeutic contexts, from resection techniques to image-guided interventions that minimize operative risk. At the same time, novel imaging strategies provide crucial support for surgical planning, enabling better intraoperative decision-making and improving outcomes in complex gastrointestinal disease management.

By bringing together original research, clinical studies, and expert reviews, this issue seeks to provide a comprehensive overview of how modern endoscopy and imaging are being integrated into everyday practice. The ultimate goal is to highlight their role in advancing the quality, precision, and safety of gastrointestinal treatment, both medical and surgical, while underscoring the benefits for patients and clinical teams alike.

Dr. Iancu Dana Monica
Dr. Paul-Andrei Ștefan
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced endoscopy
  • gastrointestinal imaging
  • minimally invasive therapy
  • early diagnosis
  • image-guided intervention
  • surgical planning
  • patient outcomes
  • gastrointestinal diseases

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Published Papers (2 papers)

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Research

14 pages, 8065 KB  
Article
Percutaneous Endoscopic Necrosectomy of Walled-Off Pancreatic and Peripancreatic Necrosis
by Mateusz Jagielski, Agata Chwarścianek, Damian Dudek, Jacek Piątkowski and Marek Jackowski
J. Clin. Med. 2026, 15(2), 470; https://doi.org/10.3390/jcm15020470 - 7 Jan 2026
Viewed by 680
Abstract
Background: Minimally invasive approaches for managing complications of acute necrotizing pancreatitis have advanced significantly in recent decades. When extensive walled-off pancreatic or peripancreatic necrosis is present, a single transluminal access may be insufficient. This study aimed to prospectively evaluate the effectiveness and [...] Read more.
Background: Minimally invasive approaches for managing complications of acute necrotizing pancreatitis have advanced significantly in recent decades. When extensive walled-off pancreatic or peripancreatic necrosis is present, a single transluminal access may be insufficient. This study aimed to prospectively evaluate the effectiveness and safety of a novel percutaneous endoscopic necrosectomy technique used as an adjunct to transmural drainage in patients with symptomatic walled-off necrosis. Methods: A total of 513 consecutive patients with symptomatic walled-off pancreatic or peripancreatic necrosis treated between 2018 and 2025 at a single tertiary center in Poland were included. All patients underwent minimally invasive endoscopic management. Among them, a subgroup required additional percutaneous drainage. The innovative technique involved creating retroperitoneal percutaneous access to the necrotic cavity, enlarging the tract, and placing a self-expanding metal stent to allow passage of the endoscope for percutaneous endoscopic necrosectomy. Results: Additional percutaneous drainage was necessary in 39/513 patients (7.6%). Of these, 9/39 (23.1%) patients (2 women, 7 men; mean age 46.7 years) underwent percuaneous endoscopic necrosectomy. The mean size of the necrotic collection was 25.96 cm. Active percutaneous drainage during ongoing transmural endotherapy lasted a median of 15 days. Patients underwent an average of 3.12 necrosectomy sessions. Treatment-related complications occurred in 2/9 patients (22.22%). Clinical and long-term success were each achieved in 8/9 patients (88.89%). Conclusions: Percutaneous endoscopic necrosectomy is a promising minimally invasive therapeutic option for extensive walled-off pancreatic and peripancreatic necrosis, particularly when necrosis extends into the pelvic region. However, clinical evidence remains limited and further studies are needed. Full article
(This article belongs to the Special Issue Advanced Endoscopy and Imaging in Gastrointestinal Diseases)
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9 pages, 1183 KB  
Article
Duration and Predictive Factors of Plastic Biliary Stent Patency: Results of a Large Prospective Database Analysis
by Egle Dieninyte, Eugenijus Jasiunas, Aistis Lemezis, Emilija Kezeviciute, Juozas Stanaitis and Tomas Poskus
J. Clin. Med. 2025, 14(24), 8788; https://doi.org/10.3390/jcm14248788 - 11 Dec 2025
Viewed by 576
Abstract
Background/Objectives: Endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement is a mainstay of current management for biliary obstruction, with stent occlusion being the most common and severe complication. The mechanism of stent occlusion is well known; however, factors affecting individual stent patency [...] Read more.
Background/Objectives: Endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement is a mainstay of current management for biliary obstruction, with stent occlusion being the most common and severe complication. The mechanism of stent occlusion is well known; however, factors affecting individual stent patency are still controversial. The objective of this study was to determine the duration and factors affecting plastic biliary stent patency. Methods: We conducted a retrospective analysis of the consecutive procedures of endoscopic retrograde cholangiopancreatography (ERCP) and biliary stent placement in a single tertiary center during the period of 2010–2019. The primary outcome of the study was the time of stent patency. Secondary outcomes were the development of cholangitis upon re-stenting and whether subsequent re-stenting was emergent. Re-stenting was considered emergent if it happened before the planned elective re-stenting date, irrespective of indication (development of cholangitis, rising jaundice, suspected dislodgement, etc.). Results: Between 2010 and 2019, a total of 5462 ERCP procedures were performed, with 2659 resulting in plastic biliary stent placement. On average, the plastic biliary stent was patent for 63 (25, 96) days with significant differences between the indications for ERCP groups. The strongest risk factors for the development of cholangitis upon re-stenting was cholangitis during index ERCP (HR = 1.83; 95% CI: 1.48–2.27; p < 0.001), intrabiliary malignancy being the indication for stenting (HR = 1.34; 95% CI: 1.12–1.60; p < 0.001) and increasing number of stents being placed (HR = 1.73; 95% CI: 1.27–2.36; p < 0.001). Conclusions: Patients with an underlying malignancy, history of cholangitis, and multiple biliary stents are at an increased risk for stent occlusion and cholangitis, warranting a tailored stent exchange interval to prevent complications. Full article
(This article belongs to the Special Issue Advanced Endoscopy and Imaging in Gastrointestinal Diseases)
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