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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Challenges in Syringomyelia

edited by

Palma Ciaramitaro

submission deadline 30 Dec 2026 | 1 articles | Viewed by 542 | Submission Open

Keywords: syringomyelia; epidemiology; genetics; hydrodynamics; cerebro-spinal fluid; MRI; neurophysiology; surgery; outcome measures; natural history

(This special issue belongs to the Section Clinical Neurology)

Local Treatments for Oligometastatic Non-Small Cell Lung Cancer

edited by Elena Prisciandaro and

Luca Bertolaccini

submission deadline 30 Dec 2026 | Viewed by 250 | Submission Open

Keywords: lung cancer; NSCLC; oligometastatic cancer; lung resection; lung surgery; pulmonary radiotherapy; SBRT; local treatments

(This special issue belongs to the Section Respiratory Medicine)

Advances in Musculoskeletal Tumor Surgery and Limb Salvage Reconstruction

edited by Alexander Christ and Brandon Gettleman

submission deadline 30 Dec 2026 | Viewed by 228 | Submission Open

Keywords: musculoskeletal oncology; limb salvage; sarcoma surgery; metastatic bone disease; oncologic reconstruction; patho-logic fracture; endoprosthetic reconstruction; arthroplasty; surgical outcomes; complications

(This special issue belongs to the Section Orthopedics)

Challenges in Gynecologic Cancers

edited by

Marcin Mardas

submission deadline 30 Dec 2026 | Viewed by 216 | Submission Open

Keywords: ovarian cancer; endometrial cancer; uterine cancer; cervical cancer; vulvar cancer; nutrition in cancer; chemotherapy; immunotherapy; targeted therapies; surgery; mini-invasive surgery; robotic surgery

(This special issue belongs to the Section Obstetrics & Gynecology)

New Advances in Wound Healing and Skin Wound Treatment

edited by Hajime Matsumura

submission deadline 31 Dec 2026 | 13 articles | Viewed by 37633 | Submission Open

Keywords: trauma wound; burns; chronic wound; DFU; VLU; ischemic wound; regenerative medicine in wound care; debridement; biofilm; wound dressing; antimicrobial treatment

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Sequelae of COVID-19: Clinical to Prognostic Follow-Up

edited by

Mariana Tudoran

and

Cristina Tudoran

submission deadline 31 Dec 2026 | 15 articles | Viewed by 24470 | Submission Open

Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19

(This special issue belongs to the Section Vascular Medicine)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by

Alfredo Papa

and Loris Riccardo Lopetuso

submission deadline 31 Dec 2026 | 6 articles | Viewed by 9990 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advancing Clinical Medicine Through Artificial Intelligence (AI) and Digital Technology: 2nd Edition

edited by

Antonio Jorge Forte

Syed Ali Haider

and

Mark Lifson

submission deadline 31 Dec 2026 | 5 articles | Viewed by 9200 | Submission Open

Keywords: artificial intelligence; clinical medicine; medical imaging; precision medicine; clinical decision support systems; patient care; healthcare practices; early disease detection; patient outcomes

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

Progress in Clinical Diagnosis and Therapy in Ophthalmology

edited by

Edward Wylegala

submission deadline 31 Dec 2026 | 8 articles | Viewed by 7424 | Submission Open

Keywords: ophthalmic imaging; artificial intelligence in ophthalmology; retinal diseases; corneal transplantation; glaucoma diagnostics; ocular therapeutics; personalized medicine; ocular genetics

(This special issue belongs to the Section Ophthalmology)

Early Prevention and Diagnosis of Atherosclerosis: From Clinical Progression to Patient Management

edited by

Anna Kabłak-Ziembicka

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6224 | Submission Open

Keywords: atherosclerosis; atherothrombotic molecular pathways; cardiovascular risk; monitoring of goals; pharmacological and non-pharmacological prevention; carotid and peripheral interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advancements in Intraocular Lens Power Calculation Methods

edited by

Christoph Martin Lwowski

and Thomas Kohnen

submission deadline 31 Dec 2026 | 4 articles | Viewed by 5503 | Submission Open

Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry

(This special issue belongs to the Section Ophthalmology)

Dental Care: Oral and Systemic Disease Prevention: 2nd Edition

edited by

Kacper Nijakowski

submission deadline 31 Dec 2026 | 4 articles | Viewed by 5388 | Submission Open

Keywords: oral health; oral diseases; oral manifestations; systemic diseases; oral care; dental prevention; dental caries; periodontal disease; oral medicine; dentistry; oral microbiome; salivary diagnostics; AI-assisted tools

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Anemia: Clinical Updates in Diagnosis, Management, and Treatment

edited by

Joan-Lluis Vives-Corrons

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2757 | Submission Open

Keywords: anemia; diagnostic tools; hematology; artificial intelligence; targeted therapy; hereditary hemolytic anemia

(This special issue belongs to the Section Hematology)

Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition

edited by

Vera Geraldes

and

Isabel Rocha

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2755 | Submission Open

Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms

(This special issue belongs to the Section Cardiology)

Acute and Chronic Hemodialysis: Clinical Updates and Advances

edited by

Gubensek Jakob

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2434 | Submission Open

Keywords: hemoadsorption; hemodiafiltration; medium cut-off membranes; expanded hemodialysis; vascular calcifications; renal anemia; vascular access; anticoagulation; ICU nephrology; acute kidney injury

(This special issue belongs to the Section Nephrology & Urology)

How Clinicians See the Use of AI in Psychiatry

edited by

Georgios Floros

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1465 | Submission Open

Keywords: artificial intelligence; psychiatry; patient care; psychotherapy

(This special issue belongs to the Section Mental Health)

Challenges and Solutions in Geriatric Fracture

edited by Detlef Van der Velde and

Henk Jan Schuijt

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1385 | Submission Open

Keywords: geriatric; fracture; frailty; hip fracture; comorbidity; perioperative optimization; orthogeriatrics; rehabilitation; shared decision-making; postoperative outcomes; mortality and morbidity; functional recovery; multidisciplinary care; quality of life; recovery; mobility; palliative care

(This special issue belongs to the Section Geriatric Medicine)

Advances in Artificial Intelligence Applications for Invasive and Non-Invasive Cardiovascular Procedures

edited by

Oladipupo Olafiranye

and Rahul Chaudhary

submission deadline 31 Dec 2026 | 1 articles | Viewed by 762 | Submission Open

Keywords: artificial intelligence and machine learning; interventional cardiology; electrophysiology; cardiovascular imaging; remote patient monitoring; digital biomarkers; clinical decision support

(This special issue belongs to the Section Cardiovascular Medicine)

Innovations in Heart Failure: Clinical and Surgical Perspectives

edited by

Marco Gemelli

and Vincenzo Tarzia

submission deadline 31 Dec 2026 | Viewed by 299 | Submission Open

Keywords: heart failure; heart transplantation; mechanical circulatory support; optimal medical therapy; LVAD; multidisciplinary care

(This special issue belongs to the Section Cardiology)

Critical Care Medicine: Innovation and Long-Term Patient Outcomes

edited by Charlie Corke

submission deadline 31 Dec 2026 | Viewed by 191 | Submission Open

Keywords: critical care innovation; patient-centred outcomes; goals-of-care decision-making; advanced organ sup-port; ethical and sustainable intensive care

(This special issue belongs to the Section Intensive Care)

Advances in Gynecological Cancers: Diagnosis, Treatment, and Care

edited by

Marek Murawski

, Dariusz Wydra and

Ewa Szuster

submission deadline 31 Dec 2026 | Viewed by 170 | Submission Open

Keywords: preinvasive cervical disease; cervical cancer; endometrial cancer; ovarian cancer; borderline ovarian tumors; rare tumors; uterine sarcoma; vulvar cancer; vaginal cancer; fertility sparing management; biomarkers; precision medicine; targeted therapy; immunotherapy; early detection

(This special issue belongs to the Section Obstetrics & Gynecology)

State of the Art of Corneal: Current Status and Prospects

edited by Justyna Izdebska

submission deadline 31 Dec 2026 | Viewed by 124 | Submission Open

Keywords: corneal diseases; corneal transplantation; OCT; corneal imaging; refractive surgery; keratoconus; graft survival; immunosuppression

(This special issue belongs to the Section Ophthalmology)

Multiparametric Ultrasound Techniques for Liver Disease Assessments

edited by Francesco Giangregorio

submission deadline 5 Jan 2027 | 2 articles | Viewed by 7858 | Submission Open

Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Challenging ICU Dogma: Where Routine Practice and Evidence Collide

edited by

Yujiro Matsuishi

and Nobutake Shimojo

submission deadline 10 Jan 2027 | 2 articles | Viewed by 13874 | Submission Open

Keywords: critical care; intensive care unit (ICU); clinical dogma; de-implementation; medical reversal; routine practices; clinical decision-making

(This special issue belongs to the Section Intensive Care)

New Clinical Advances in Pancreatobiliary Diseases

edited by

Kyong Joo Lee

submission deadline 10 Jan 2027 | 4 articles | Viewed by 7272 | Submission Open

Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Thyroid Disorders: New Clinical Diagnosis and Management

edited by

Ioannis P. Iakovou

Rodis D. Paparodis

and

Nicholaos G. Angelopoulos

submission deadline 10 Jan 2027 | 2 articles | Viewed by 4017 | Submission Open

Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging

(This special issue belongs to the Section Endocrinology & Metabolism)

Dialysis Versus Transplantation: Navigating Treatment Strategies in Chronic Kidney Disease

edited by

Andreja Figurek

submission deadline 10 Jan 2027 | Viewed by 239 | Submission Open

Keywords: chronic kidney disease; kidney failure; dialysis; kidney transplantation; renal replacement therapy; hemodialysis; peritoneal dialysis; pre-emptive transplantation; patient-centered care; quality of life; precision nephrology; biomarkers; artificial intelligence; health disparities; treatment decision-making

(This special issue belongs to the Section Nephrology & Urology)

Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD)

edited by

Alessandro Pallucchini

submission deadline 15 Jan 2027 | 4 articles | Viewed by 11744 | Submission Open

Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone

(This special issue belongs to the Section Mental Health)

Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions

edited by Pietro C. Dattolo and

Aris Tsalouchos

submission deadline 15 Jan 2027 | 4 articles | Viewed by 7453 | Submission Open

Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Clinical Updates on Pediatric Surgery

edited by Carlos Theodore Huerta and Eduardo Alfonso Perez

submission deadline 15 Jan 2027 | 4 articles | Viewed by 3522 | Submission Open

Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality

(This special issue belongs to the Section Clinical Pediatrics)

Pediatric Pulmonology: Current Hurdles and Future Perspectives

edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín

submission deadline 15 Jan 2027 | 2 articles | Viewed by 3510 | Submission Open

Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics

(This special issue belongs to the Section Clinical Pediatrics)

Current Challenges in Oral and Maxillofacial Surgery

edited by

Federica Canfora

and

Lucia Memé

submission deadline 15 Jan 2027 | 2 articles | Viewed by 3076 | Submission Open

Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 15 Jan 2027 | 2 articles | Viewed by 2391 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Clinical Diagnosis and Management of Erectile Dysfunction

edited by Maurizio De Rocco Ponce and

Giuseppe Grande

submission deadline 15 Jan 2027 | 2 articles | Viewed by 2158 | Submission Open

Keywords: erectile dysfunction; clinical management; cardiovascular disease; penile prosthesis; personalized medicine; hipogonadism

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Cutting Edge Research on Total Knee Arthroplasty

edited by

Nahum Rosenberg

submission deadline 15 Jan 2027 | 2 articles | Viewed by 2034 | Submission Open

Keywords: total knee arthroplasty; robotic-assisted surgery; computer-navigated arthroplasty; implant design; kinematic alignment; enhanced recovery pathways; patient-reported outcomes; artificial intelligence in orthopedics; revision surgery

(This special issue belongs to the Section Orthopedics)

Aortic Surgery: State of the Art and Future Directions

edited by

Dimos E. Karangelis

submission deadline 15 Jan 2027 | 2 articles | Viewed by 1384 | Submission Open

Keywords: aortic surgery; aortic aneurysm; aortic dissection; aortic arch; biomaterials; endovascular approach; FET; TEVAR

(This special issue belongs to the Section Cardiovascular Medicine)

Complications Related to Coronary Artery Disease and Secondary Prevention Strategies

edited by Nazanin Rajai

submission deadline 15 Jan 2027 | 1 articles | Viewed by 375 | Submission Open

Keywords: coronary artery disease; complications; secondary prevention; myocardial infarction; cardiovascular risk; heart failure; arrhythmias; imaging; biomarkers; cardiovascular pharmacotherapy

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 20 Jan 2027 | 9 articles | Viewed by 16145 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Effect of Long-Term Insomnia on Mental Health—2nd Edition

edited by

Aleksandra Rogowska

submission deadline 20 Jan 2027 | 2 articles | Viewed by 13471 | Submission Open

Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress

(This special issue belongs to the Section Mental Health)

Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome

edited by

Razvan Ionut Ghinea

Ioana-Sofia Pop-Ciutrilă

and

Luminita-Maria Nica

submission deadline 20 Jan 2027 | 4 articles | Viewed by 11463 | Submission Open

Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Management and Long-Term Prognosis in Intensive Care

edited by

Wioletta Mędrzycka-Dąbrowska

and

Sandra Lange

submission deadline 20 Jan 2027 | 9 articles | Viewed by 10808 | Submission Open

Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation

(This special issue belongs to the Section Intensive Care)

Glaucoma Surgery: Current Challenges and Future Perspectives

edited by

Tina Tzee Ling Wong

and

Esther M. Hoffmann

submission deadline 20 Jan 2027 | 8 articles | Viewed by 8817 | Submission Open

Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics

(This special issue belongs to the Section Ophthalmology)

Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition

edited by

Teresa Paolucci

and

Massimiliano Mangone

submission deadline 20 Jan 2027 | 4 articles | Viewed by 8078 | Submission Open

Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses

(This special issue belongs to the Section Orthopedics)

Acute Medical Threats: Evidence-Driven Strategies in Emergency Medicine

edited by

Alexandra Arvanitaki

submission deadline 20 Jan 2027 | 4 articles | Viewed by 7530 | Submission Open

Keywords: emergency medicine protocols; acute medical care; trauma management; resuscitation; critical care; infectious disease preparedness

(This special issue belongs to the Section Emergency Medicine)

Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types

edited by Andrea Paradisi

submission deadline 20 Jan 2027 | 4 articles | Viewed by 7241 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)

(This special issue belongs to the Section Dermatology)

Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments

edited by

Niccola Funel

, Paolo Domenico Parchi and Andrea del Chiaro

submission deadline 20 Jan 2027 | 5 articles | Viewed by 7160 | Submission Open

Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis, osteoarthritis, musculoskeletal disorder, pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches

(This special issue belongs to the Section Orthopedics)

Heart Failure: Challenges and Future Options

edited by Pedro Caravaca-Pérez and Marta Farrero-Torres

submission deadline 20 Jan 2027 | 7 articles | Viewed by 7099 | Submission Open

Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes

edited by Giovanni Colombo and

Matteo Di Bari

submission deadline 20 Jan 2027 | 5 articles | Viewed by 6038 | Submission Open

Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life

(This special issue belongs to the Section Otolaryngology)

Hospital-Acquired Infections: Insights, Prevention, and Control Strategies

edited by

Andrea Fabbri

submission deadline 20 Jan 2027 | 4 articles | Viewed by 4918 | Submission Open

Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department

(This special issue belongs to the Section Epidemiology & Public Health)

Clinical Updates in Transfusion Medicine and Patient Blood Management

edited by

Carlos Jerico

and

José Antonio García-Erce

submission deadline 20 Jan 2027 | 1 articles | Viewed by 4901 | Submission Open

Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine

(This special issue belongs to the Section Hematology)

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