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Clinical Advancements in Intraocular Lens Power Calculation Methods

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 483

Special Issue Editors


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Guest Editor
Department of Ophthalmology, Goethe-Universität Frankfurt am Main, Frankfurt, Germany
Interests: IOL; IOL power calculation; refractive surgery; lens exchange; cataract surgery; presbyopia; multifocal IOL; effective lens position; biometry; strabismus; oculoplastic; neuro-ophthalmology; orbital surgery

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Guest Editor
Department of Ophthalmology, University Hospital Goethe University, Frankfurt, Germany
Interests: refractive surgery; IOL; cataract surgery; refractive lens exchange; presbyopia; phakic IOL; presbyopia correcting IOL; EDOF; multifocal IOL

Special Issue Information

Dear Colleagues,

Cataract surgery is one of the most common performed procedures worldwide. Additionally, patients are becoming more demanding in terms of refractive outcome and, therefore, hitting target refraction is more and more important. This is why the calculation of the optimal intraocular lens is a crucial factor for the success of cataract and refractive lens surgery and one of the main parameters for post-op patient satisfaction. This Special Issue is meant to highlight recent advances in IOL calculation, presenting innovative algorithms, biometric measurement techniques, and personalized calculation approaches.

Possible key technologies to optimize lens power selection could be artificial intelligence and machine learning. Additionally, new formulas such as the Barrett Universal II, Hill-RBF, and Kane formulas are already outperforming older generations of formulas, showing higher predictability for a wider range of eyes. The impact of cutting-edge biometric devices, including swept-source OCT technology, on calculation accuracy is also one factor of the current advancements in meeting postop expectations.

Beyond technological advancements, practical recommendations for improving postoperative refractive accuracy, particularly in patients with previous procedures such as corneal refractive surgery of silicone oil fill in retinal detachment eyes, are needed. In this Special Issue, we invite experts to submit studies on IOL calculation using modern or AI formulas, comparing biometry, and giving recommendations on which calculation method to use in complex eyes like those post-refractive surgery.

Dr. Christoph Martin Lwowski
Prof. Dr. Thomas Kohnen
Guest Editors

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Keywords

  • emmetropia
  • IOL power calculation
  • effective lens position
  • refractive lens exchange
  • IOL
  • refractive surgery
  • biometry

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Published Papers (1 paper)

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Research

15 pages, 1407 KiB  
Article
Evaluation of a Simple and Accurate Method for Intraocular Lens Constant Optimization Using Linear Interpolation
by Sumitaka Miyamoto and Kazutaka Kamiya
J. Clin. Med. 2025, 14(13), 4543; https://doi.org/10.3390/jcm14134543 - 26 Jun 2025
Viewed by 378
Abstract
Objectives: We devised a simple and practical method for optimizing intraocular lens (IOL) constants using linear interpolation, based on the IOL power calculation study protocol proposed by Hoffer et al., and evaluated its effectiveness. Methods: This retrospective study included 188 eyes [...] Read more.
Objectives: We devised a simple and practical method for optimizing intraocular lens (IOL) constants using linear interpolation, based on the IOL power calculation study protocol proposed by Hoffer et al., and evaluated its effectiveness. Methods: This retrospective study included 188 eyes from 188 Japanese patients who underwent cataract surgery with the implantation of CNA0T0 (Alcon) between June 2022 and September 2024. Preoperative biometric data were obtained using ARGOS (Alcon) and OA-2000 (Tomey). Predicted refractions were calculated using the European Society of Cataract and Refractive Surgeons’ (ESCRS) IOL Web Calculator with the EVO, Hill-RBF 3.0 (Hill), and Kane formulas, using both A-constants of 119.1 and 119.33. The mean prediction error (MPE) was calculated as the difference between the predicted and postoperative spherical equivalent at 3 months. Linear interpolation was applied to the paired results to derive optimized A-constants yielding MPE = 0 and to correct each case’s predicted refraction values (“corrected values”). Additionally, predicted refractions were recalculated using the optimized A-constants with the ESCRS IOL Web Calculator to obtain “actual values”. Both corrected and actual values achieved an MPE of 0 and were compared using the Friedman test and Cochran’s Q test. Results: The optimized A-constants for ARGOS were 119.540 (EVO), 119.733 (Hill), and 119.563 (Kane); for OA-2000, they were 119.388, 119.532, and 119.417, respectively. No significant differences were found between corrected and actual values under any condition. Conclusions: This method is simple, accurate, and applicable to new IOLs, devices, and formulas, with potential to improve the precision of clinical IOL power calculations. Full article
(This article belongs to the Special Issue Clinical Advancements in Intraocular Lens Power Calculation Methods)
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