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New Advances in Wound Healing and Skin Wound Treatment
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New Advances in Wound Healing and Skin Wound Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 5507

Special Issue Editor

Prof. Dr. Hajime Matsumura

E-Mail Website
Guest Editor
Department of Plastic and Reconstructive Surgery, Tokyo Medical University, Tokyo 160-0023, Japan
Interests: burns; acute and chronic wounds; regenrative medicine; tissue engineering; wound healing

Special Issue Information

Dear Colleagues,

The treatment of skin defects, including burns, traumatic skin defects, and chronic wounds such as DFUs and VLUs, has seen significant progress in recent years. This is largely due to advances in research into the pathophysiology of wound healing in various conditions, as well as the introduction of new treatment devices and drugs, the use of wound healing matrices such as CAMPs, and the introduction of regenerative medicine and tissue engineering. Another key focus is on local infections and biofilms that impede wound healing, and new strategies and treatment approaches are currently being developed. There have also been significant advances in the treatment of ischemic wounds. Thus, we are launching this Special Issue to share new knowledge on wound care.

We invite researchers from around the world to submit their work showcasing new perspectives on wound healing, innovative technologies, and evidence-based practice. Our goal is to highlight advances that will revolutionize wound healing and ultimately improve outcomes for patients.

We invite you to join us on our journey to advance this field through collaboration and knowledge sharing. We look forward to receiving your submissions.

Prof. Dr. Hajime Matsumura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • trauma wound
  • burns
  • chronic wound
  • DFU
  • VLU
  • ischemic wound
  • regenerative medicine in wound care
  • debridement
  • biofilm
  • wound dressing
  • antimicrobial treatment
 

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Published Papers (5 papers)

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11 pages, 1581 KB  
Article
Combining Topical Oxygen and Negative-Pressure Wound Therapy: New Insights from a Pilot Study on Chronic Wound Treatment
by Bartosz Molasy, Mateusz Frydrych, Rafał Kuchciński and Stanisław Głuszek
J. Clin. Med. 2025, 14(15), 5564; https://doi.org/10.3390/jcm14155564 - 7 Aug 2025
Viewed by 469
Abstract
Background: Chronic wounds are a growing clinical challenge due to their prolonged healing time and associated healthcare burden. Combined therapeutic approaches, including topical oxygen therapy (TOT) and negative-pressure wound therapy (NPWT), have shown promise in enhancing wound healing. This pilot exploratory study aimed [...] Read more.
Background: Chronic wounds are a growing clinical challenge due to their prolonged healing time and associated healthcare burden. Combined therapeutic approaches, including topical oxygen therapy (TOT) and negative-pressure wound therapy (NPWT), have shown promise in enhancing wound healing. This pilot exploratory study aimed to assess the clinical effectiveness of combined TOT and NPWT in chronic wound treatment and to explore the prognostic value of selected laboratory and thermographic markers. Methods: Eighteen patients with chronic wounds due to type 2 diabetes mellitus or chronic venous insufficiency were treated with either TOT alone (control group) or TOT combined with NPWT (intervention group). Wound characteristics, thermographic data, and laboratory parameters (NLR, MLR, PLR, CRP, and total protein) were collected at baseline and during therapy. The primary endpoints were the total treatment duration and complete wound closure. Statistical analyses were exploratory and used non-parametric tests, correlation analyses, and simple linear regression. Results: Ulcer duration was significantly associated with the wound surface area. Lower serum total protein levels correlated negatively with ulcer duration, wound size, and granulation tissue area. A significant reduction in treatment duration was observed in the intervention group compared to the controls. One strong correlation was found between MLR and peripheral wound temperature on day 7 in the control group. No significant group differences were observed in wound size or thermographic measures after one week of treatment. Conclusions: Combining TOT and NPWT may reduce treatment duration in chronic wound management. Selected laboratory and thermographic markers show promise as prognostic tools. These exploratory findings require confirmation in larger, randomized trials. Full article
(This article belongs to the Special Issue New Advances in Wound Healing and Skin Wound Treatment)
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14 pages, 2158 KB  
Article
Association of Combined Enzymatic and Surgical Debridement with Clinical Outcomes in Extensive Burn Patients
by Yasuhiko Kaita, Mikio Nakajima, Takeaki Matsuda and Yoshihiro Yamaguchi
J. Clin. Med. 2025, 14(15), 5233; https://doi.org/10.3390/jcm14155233 - 24 Jul 2025
Viewed by 687
Abstract
Background/Objectives: Burned tissue has traditionally been removed surgically, but the effectiveness of enzymatic debridement with NexoBrid has been reported in burn patients and has gained attention in recent years. This agent was approved for use in Japan in 2023. However, even in [...] Read more.
Background/Objectives: Burned tissue has traditionally been removed surgically, but the effectiveness of enzymatic debridement with NexoBrid has been reported in burn patients and has gained attention in recent years. This agent was approved for use in Japan in 2023. However, even in Japan, there have been few studies examining its effectiveness in patients with extensive burns. The purpose of this study was to analyze the association of combined NexoBrid and surgical excision with clinical outcomes in extensive burn patients. Methods: Between January 2020 and December 2024, seventeen flame burn patients requiring surgical excision were divided into two groups based on whether NexoBrid was used. Clinical outcomes between the two groups were compared using the propensity score overlap weighting method to adjust for baseline differences. Results: Seven of the patients received combined NexoBrid and surgical excision. After weighting, NexoBrid was significantly associated with a shorter time to complete debridement of burned tissue (difference −4 days, 95% CI −5 to −2) and lower percentage of bacteremia (odds ratio 0.06, 95% CI 0.00 to 0.96). However, no significant differences were observed in the length of ICU stay, the amount of blood transfusion required for complete tissue removal, hospitalization costs, and in-hospital mortality. Conclusions: Combining conventional surgical excision with enzymatic debridement may reduce the time required to complete debridement of burned tissue and decrease the rate of bacteremia. Further studies are needed to evaluate the effectiveness of NexoBrid combined with surgical excision in patients with extensive burns. Full article
(This article belongs to the Special Issue New Advances in Wound Healing and Skin Wound Treatment)
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15 pages, 1324 KB  
Article
The Effectiveness of Low-Density Lipoprotein/Fibrinogen Apheresis in Promoting Wound Healing of No-Option Chronic Limb-Threatening Ischemia Foot Ulcers with Wound, Ischemia, and Foot Infection (WIfI) Wound Grade 3: A Single-Center Retrospective Analysis
by Miki Fujii, Haruna Hirai, Rei Tomyo, Ryo Mizobuchi, Ai Omori, Rica Tanaka and Hiroshi Mizuno
J. Clin. Med. 2025, 14(8), 2589; https://doi.org/10.3390/jcm14082589 - 9 Apr 2025
Viewed by 979
Abstract
Background: Chronic limb-threatening ischemia (CLTI) is a severe condition associated with high mortality and amputation rates, particularly in patients with diabetes, renal failure, or severe vascular disease. In cases where revascularization fails or is not possible, adjunctive therapies can improve the treatment outcomes. [...] Read more.
Background: Chronic limb-threatening ischemia (CLTI) is a severe condition associated with high mortality and amputation rates, particularly in patients with diabetes, renal failure, or severe vascular disease. In cases where revascularization fails or is not possible, adjunctive therapies can improve the treatment outcomes. Therefore, this single-center retrospective study aimed to evaluate the effectiveness of low-density lipoprotein/fibrinogen apheresis (Rheocarna®) in promoting wound healing in patients with no-option CLTI, focusing on large wounds. Methods: We examined the data of 32 CLTI ulcers treated with Rheocarna® from 2021 to 2024. Results: The outcomes in 25 cases (78.1%) were rated as excellent or good, and the outcomes of 11 (73.3%) wound, ischemia, and foot infection (WIfI) wound-3 ulcers were excellent or good. Overall, 75% of the CLTI ulcers achieved wound healing without major amputation. Predictive factors for successful wound healing included age, baseline skin perfusion pressure, and wound grade (WIfI classification). A skin perfusion pressure threshold of 28.5 mmHg (WIfI ischemic grade 3) was a significant predictor of positive outcomes. Conclusions: Our results support the use of Rheocarna® as a viable adjunctive therapy in managing refractory large ischemic ulcers and preventing major amputations. Full article
(This article belongs to the Special Issue New Advances in Wound Healing and Skin Wound Treatment)
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12 pages, 26448 KB  
Article
Three-Dimensional Bioprinted Autologous Minimally Manipulated Homologous Adipose Tissue for Skin Defects After Wide Excision of Skin Cancer Provides Early Wound Closure and Good Esthetic Patient Satisfaction
by Reina Matsumura, Hajime Matsumura, Yuichiro Kawai, Jeehee Kim, Min-Chae Lee, Yeongseo Yu, Miki Fujii, Kazuki Shimada and Takako Komiya
J. Clin. Med. 2025, 14(6), 1795; https://doi.org/10.3390/jcm14061795 - 7 Mar 2025
Viewed by 1412
Abstract
Background: An autologous minimally manipulated homologous adipose tissue (AMHAT) fabricated using three-dimensional (3D) bioprinting has shown potential in the treatment of diabetic foot ulcers and other chronic wounds. Methods: This study assessed the efficacy of AMHAT fabricated using 3D bioprinting for treating skin [...] Read more.
Background: An autologous minimally manipulated homologous adipose tissue (AMHAT) fabricated using three-dimensional (3D) bioprinting has shown potential in the treatment of diabetic foot ulcers and other chronic wounds. Methods: This study assessed the efficacy of AMHAT fabricated using 3D bioprinting for treating skin defects after a wide excision of skin cancer lesions where primary closure was not feasible. A total of 10 consecutive patients were included. The wounds were photographed and analyzed using AI, and the fat tissue harvested from the lower abdomen was processed into an AMHAT patch using a 3D bioprinter. The wound area was measured weekly until complete wound closure was achieved. Results: The area of the skin defects ranged from 1.77–6.22 cm2, averaging 2.72 cm2. Complete closure was achieved in 3–5 (average, 4.2) weeks. The residual area decreased from 52% after 1 week to 3% after 4 weeks. The scar appearance was esthetically favorable, with one patient showing mild nostril asymmetry. Furthermore, patient-reported outcome evaluation using the Japanese version of SCAR-Q for postoperative scars showed a very high level of satisfaction. Conclusions: The 3D bioprinted AMHAT accelerates wound healing with minimal scarring, offering an important option for skin defects where esthetics are a priority. Full article
(This article belongs to the Special Issue New Advances in Wound Healing and Skin Wound Treatment)
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14 pages, 3090 KB  
Case Report
The Use of Larval Debridement Therapy and Negative-Pressure Wound Therapy for an Infected Wound After Thyroidectomy—A Case Report
by Jolanta Dynarska, Edyta Zagrodnik, Agnieszka Kisielska, Anna Jurczak, Tomasz Machałowski and Sylwia Wieder-Huszla
J. Clin. Med. 2025, 14(16), 5634; https://doi.org/10.3390/jcm14165634 - 9 Aug 2025
Viewed by 1355
Abstract
Background: Larval debridement therapy is used to cleanse necrotic tissue wounds and/or decontaminate wounds that are not amenable to standard therapies. Methods: A patient was diagnosed with septic shock and multiple organ failure caused by Streptococcus pyogenes after thyroidectomy (the patient had experienced [...] Read more.
Background: Larval debridement therapy is used to cleanse necrotic tissue wounds and/or decontaminate wounds that are not amenable to standard therapies. Methods: A patient was diagnosed with septic shock and multiple organ failure caused by Streptococcus pyogenes after thyroidectomy (the patient had experienced contact with a child with scarlet fever six days before admission to the hospital). As a result of systemic infection, numerous necrotic skin lesions appeared, which involved the surgical site, chest and scalp. A tracheocutaneous fistula was confirmed. Due to the ineffectiveness of typical therapy and the patient’s severe clinical condition, she qualified for unconventional therapy (larval debridement therapy). Results: Larval wound debridement therapy and negative-pressure wound therapy were used for the tracheocutaneous fistula; this is the first case of this alternative therapy being described in the English-language literature. In this case, based on an analysis of the health benefits for the patient and the uncertain prognosis, larval therapy was used for a postoperative wound after strumectomy with the presence of a tracheocutaneous fistula, and negative-pressure wound therapy ultimately led to complete wound healing. Conclusions: Sepsis caused by Streptococcus pyogenes can be fulminant and often leads to complications or death, especially if it develops in the perioperative period. Larval therapy can be effectively used in cases of fistulas, such as tracheocutaneous fistulas, to prepare the wound bed for the next stage of healing using negative-pressure therapy, which ultimately leads to complete wound healing. Full article
(This article belongs to the Special Issue New Advances in Wound Healing and Skin Wound Treatment)
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