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Progress in Clinical Diagnosis and Therapy in Ophthalmology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 16 March 2026 | Viewed by 323

Special Issue Editor


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Guest Editor
Clinical Department of Ophthalmology, Faculty of Medical Science Division in Zabrze, Medical University of Silesia, Katowice, Poland
Interests: keratoconus; deep anterior lamellar keratoplasty; penetrative keratoplasty; ophthalmology
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Special Issue Information

Dear Colleagues,

Ophthalmology is undergoing a transformative era marked by significant advancements in diagnostic precision and therapeutic innovation. The integration of high-resolution imaging technologies, artificial intelligence, and molecular diagnostics is reshaping how eye diseases are detected, monitored, and treated. Genetic discoveries have particularly deepened our understanding of inherited retinal disorders, glaucoma, and corneal dystrophies, paving the way for targeted therapies and gene-based interventions. At the same time, innovations in pharmacology, minimally invasive surgery, and tissue engineering are enhancing outcomes across a broad spectrum of ocular conditions. This Special Issue, "Progress in Clinical Diagnosis and Therapy in Ophthalmology", aims to present the latest developments in these rapidly evolving areas. Submissions are encouraged that explore breakthroughs in imaging, AI-assisted diagnostics, gene therapy, regenerative medicine, and other personalized approaches that promise to define the future of eye care. Interdisciplinary studies and translational research with clinical relevance are particularly welcome.

Prof. Dr. Edward Wylegala
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ophthalmic imaging
  • artificial intelligence in ophthalmology
  • retinal diseases
  • corneal transplantation
  • glaucoma diagnostics
  • ocular therapeutics
  • personalized medicine
  • ocular genetics

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Published Papers (1 paper)

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Research

14 pages, 457 KiB  
Article
Triple Procedure Long-Term Outcomes: Comparative Analysis of Penetrating Keratoplasty vs. DSAEK Combined with Cataract Surgery
by Dominika Szkodny, Adam Wylęgała, Agnieszka Szkaradek, Magdalena Kijonka, Magdalena Nandzik and Edward Wylęgała
J. Clin. Med. 2025, 14(16), 5670; https://doi.org/10.3390/jcm14165670 - 11 Aug 2025
Viewed by 222
Abstract
Background/Objectives: This study assessed outcomes between penetrating keratoplasty (PK) and Descemet’s stripping automated endothelial keratoplasty (DSAEK) when combined with cataract surgery as part of the triple procedure. Methods: Retrospective analysis of 727 triple procedures (525 PK and 202 DSAEK) from 2007–2023. [...] Read more.
Background/Objectives: This study assessed outcomes between penetrating keratoplasty (PK) and Descemet’s stripping automated endothelial keratoplasty (DSAEK) when combined with cataract surgery as part of the triple procedure. Methods: Retrospective analysis of 727 triple procedures (525 PK and 202 DSAEK) from 2007–2023. Graft survival, visual acuity, and refractive outcomes were analyzed. Kaplan–Meier and Cox regression were used for survival and prognostic analysis. Results: No statistically significant difference in survival was found (PK—42 months; DSAEK—47 months). DSAEK had better visual acuity improvement and refractive stability. PK had higher astigmatism and variability in refractive error. Conclusions: While graft survival was comparable, DSAEK offers superior visual rehabilitation, supporting its use when refractive predictability is important. Full article
(This article belongs to the Special Issue Progress in Clinical Diagnosis and Therapy in Ophthalmology)
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