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Thyroid Disorders: New Clinical Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 10 January 2027 | Viewed by 3454

Editors


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Guest Editor
2nd Academic Nuclear Medicine Department, Academic General Hospital of Thessaloniki “AHEPA”, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: thyroid; thyroid cancer; thyroid nodules; diabetes; endocrinology; elastography
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Hellenic Endocrine Network, 105 63 Athens, Greece
2. Loyola University Medical Center, Maywood, IL 60153, USA
3. Edward Hines Jr. VA Hospital, Hines, IL 60141, USA
Interests: autoimmunity; thyroid cancer; endocrine disruption; hashimoto's disease in thyroid carcinogenesis; endocrinology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Hellenic Endocrine Network, Ermou 6 Str., 10563 Athens, Greece
Interests: thyroid; thyroid cancer; thyroid nodules; diabetes; endocrinology; elastography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Thyroid diseases represent some of the most prevalent endocrine disorders worldwide, posing significant diagnostic and therapeutic challenges. Recent advances in imaging, molecular diagnostics, and functional assessment techniques are reshaping the way clinicians approach both benign and malignant thyroid conditions. This Special Issue, “Thyroid Disorders: New Clinical Diagnosis and Management,” invites original research and comprehensive reviews that highlight innovative methods and technologies for the diagnosis of thyroid disorders, including hypothyroidism, hyperthyroidism, thyroiditis, and thyroid cancer. Of particular interest are novel ultrasound applications, elastography, molecular and genetic testing, advanced imaging modalities, and integrated diagnostic approaches that can improve accuracy and patient outcomes. By bringing together contributions from leading experts across disciplines, this issue aims to provide a state-of-the-art overview of emerging tools that enhance clinical practice and inform personalized management strategies in thyroidology.

You may choose our Joint Special Issue in Diagnostics.

Dr. Ioannis P. Iakovou
Dr. Rodis D. Paparodis
Dr. Nicholaos G. Angelopoulos
Guest Editors

Manuscript Submission Information

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Keywords

  • thyroid disorders
  • clinical diagnosis
  • ultrasound
  • elastography
  • thyroid cancer
  • thyroiditis
  • hyperthyroidism
  • hypothyroidism
  • advanced imaging

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Published Papers (1 paper)

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31 pages, 5209 KB  
Systematic Review
Impact of Thyroid Hormone Imbalance on Electrocardiographic Parameters: Systematic Review and Meta-Analysis
by Maksymilian Kłosowicz, Magdalena Urbańczuk, Aleksandra Burbelka, Agnieszka Gala-Błądzińska and Krzysztof Balawender
J. Clin. Med. 2025, 14(24), 8755; https://doi.org/10.3390/jcm14248755 - 10 Dec 2025
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Abstract
Background: Thyroid dysfunction is a prevalent endocrine disorder with significant cardiovascular consequences, particularly through its effects on cardiac electrophysiology. Electrocardiography (ECG), as a widely available and cost-effective diagnostic tool, provides valuable insight into these alterations. This systematic review and meta-analysis aimed to evaluate [...] Read more.
Background: Thyroid dysfunction is a prevalent endocrine disorder with significant cardiovascular consequences, particularly through its effects on cardiac electrophysiology. Electrocardiography (ECG), as a widely available and cost-effective diagnostic tool, provides valuable insight into these alterations. This systematic review and meta-analysis aimed to evaluate the relationship between thyroid hormone imbalance and ECG parameters. Methods: A comprehensive search of PubMed, ScienceDirect, and Google Scholar identified 1099 studies, of which 121 underwent full-text analysis. Ultimately, 37 studies with complete datasets were included in the quantitative synthesis, encompassing 167,074 participants across overt hyperthyroidism, subclinical and overt hypothyroidism, and euthyroid control groups. Results: Meta-analysis revealed significant alterations in key electrophysiological markers. Overt hyperthyroidism was associated with QTc and Tp-e prolongation, consistent with increased repolarization heterogeneity and arrhythmic risk. In overt hypothyroidism, QTc and Tp-e intervals were also prolonged, accompanied by reduced heart rate variability, reflecting autonomic imbalance. Subclinical forms demonstrated more variable results, though trends toward conduction and repolarization disturbances were observed. Importantly, several studies indicated that levothyroxine therapy or surgical treatment normalized abnormal ECG findings, underscoring their reversible nature. Conclusions: These results highlight the strong association between thyroid hormone abnormalities and ECG alterations, which may serve as early markers of arrhythmic risk and sudden cardiac death. Incorporating ECG screening into thyroid disease management could improve early detection, risk stratification, and cardiovascular prevention strategies. Full article
(This article belongs to the Special Issue Thyroid Disorders: New Clinical Diagnosis and Management)
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