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Dental Care: Oral and Systemic Disease Prevention: 2nd Edition
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Dental Care: Oral and Systemic Disease Prevention: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 539

Special Issue Editor

Dr. Kacper Nijakowski

E-Mail Website
Guest Editor
Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland
Interests: dentistry; oral health; biostatistics; salivary diagnostics; medical education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Building upon the success of the first edition of our Special Issue "Dental Care: Oral and Systemic Disease Prevention", we are pleased to announce the launch of its 2nd Edition. This new edition aims to further explore the complex interrelationship between oral health and systemic well-being, highlighting how preventative dental care can serve as a critical component in the early detection, management, and mitigation of systemic diseases.

Recent years have brought increased awareness of how oral diseases, particularly periodontitis, dental caries, and oral infections, are linked to conditions such as diabetes mellitus, cardiovascular disease, autoimmune disorders, and even neurodegenerative diseases. Simultaneously, systemic diseases and their treatments often manifest in the oral cavity, underscoring the need for integrated care models that bridge dentistry and general medicine.

This Special Issue welcomes interdisciplinary submissions (original research articles, systematic and narrative reviews) that investigate the role of dental health in systemic disease prevention, new diagnostic technologies including AI-assisted tools, and public health strategies promoting comprehensive oral-systemic care.

Dr. Kacper Nijakowski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral health
  • oral diseases
  • oral manifestations
  • systemic diseases
  • oral care
  • dental prevention
  • dental caries
  • periodontal disease
  • oral medicine
  • dentistry
  • oral microbiome
  • salivary diagnostics
  • AI-assisted tools

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Published Papers (1 paper)

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23 pages, 1866 KB  
Systematic Review
Salivary Flow Rate in Patients with Kidney Failure on Hemodialysis—A Systematic Review and Meta-Analysis
by Parinaz Mohammadi, Casper P. Bots and Henk S. Brand
J. Clin. Med. 2025, 14(17), 6108; https://doi.org/10.3390/jcm14176108 - 29 Aug 2025
Viewed by 428
Abstract
Background/Objectives: During kidney failure, chronic hemodialysis therapy (HD) is required to replace lost renal function, and patients on regular HD frequently report xerostomia. This systematic review and meta-analysis aims to compare salivary flow rates between patients with kidney failure on HD and healthy [...] Read more.
Background/Objectives: During kidney failure, chronic hemodialysis therapy (HD) is required to replace lost renal function, and patients on regular HD frequently report xerostomia. This systematic review and meta-analysis aims to compare salivary flow rates between patients with kidney failure on HD and healthy controls and to evaluate acute changes in salivary secretion before and after a dialysis session. Methods: A systematic review was conducted in accordance with PRISMA guidelines. PubMed, Web of Science, and Embase were searched for observational studies quantifying salivary flow rates in adult patients with kidney failure on chronic hemodialysis versus healthy controls or pre- versus post-dialysis. Data on salivary flow rates were extracted and stratified by subtype (whole or gland-specific) and condition (stimulated or unstimulated), along with key study characteristics including participant demographics, saliva collection methods, and dialysis duration. Study quality was appraised using NHLBI tools and categorized as poor, fair, or good. Where ≥2 homogeneous datasets existed, random-effects meta-analyses (α = 0.05) were performed to estimate mean differences (95% CI) for each salivary parameter; heterogeneity was evaluated via I2. Results: A total of 20 studies (13 cross-sectional, 7 before-after) met inclusion, of which 17 studies (with a total of 1224 HD patients and 548 controls) were meta-analyzed. Compared with controls, HD patients showed lower secretion rates of unstimulated whole saliva (UWS: MD −0.11 mL/min; 95% CI −0.20 to −0.02; I2 = 94%) and stimulated whole saliva (SWS: MD −0.77 mL/min; 95% CI −0.94 to −0.60; I2 = 92%), whereas stimulated parotid saliva (SPS) did not differ significantly (MD −0.08 mL/min; 95% CI −0.77 to 0.60; I2 = 96%). In before-after analyses, both UWS (MD +0.15 mL/min; 95% CI 0.02–0.28; I2 = 90%) and SWS (MD +0.20 mL/min; 95% CI 0.14–0.26; I2 = 0%) increased immediately post-HD. Conclusions: Despite methodological challenges and population heterogeneity, the evidence indicates salivary hypofunction in HD patients and improvement after hemodialysis. The magnitude of these effects seems influenced by underlying comorbidities (notably diabetes), HD duration, and methodological factors. Since saliva is of major importance to maintaining good oral health, recognizing and managing dry mouth should therefore be part of the comprehensive care of patients with kidney failure. Full article
(This article belongs to the Special Issue Dental Care: Oral and Systemic Disease Prevention: 2nd Edition)
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