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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Progress in Pediatric Orthopedics and Pediatric Spine Surgery

edited by

Barbara Jasiewicz

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2871 | Submission Open

Keywords: pediatric spine; scoliosis; clubfoot; flatfoot; developmental dysplasia of the hip; rare diseases

(This special issue belongs to the Section Clinical Pediatrics)

Hypertension: Clinical Treatment and Management

edited by

José L. Flores-Guerrero

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2749 | Submission Open

Keywords: hypertension management; weight control; blood pressure monitoring; wearable technology; telemonitoring sys-tems; immune therapy; resistant hypertension; lifestyle interventions; cardiovascular health; advanced treatment strate-gies

(This special issue belongs to the Section Epidemiology & Public Health)

Advances in Clinical Exercise for Health

edited by

Pedro Miguel Forte

and Joana Ribeiro

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2666 | Submission Open

Keywords: clinical exercise science; physical activity; chronic disease prevention; biomechanics; healthy aging; physiology

(This special issue belongs to the Section Sports Medicine)

Dual-Energy and Spectral CT in Clinical Practice: 2nd Edition

edited by

Giovanni Foti

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2618 | Submission Open

Keywords: dual-energy CT; spectral CT; photon counting CT; oncology; bone marrow edema; prosthesis; liver; pancreas; lung; kidney; adrenal; brain; abdomen; cardiac; coronary arteries; arthritis

(This special issue belongs to the Section Nuclear Medicine & Radiology)

New Advances in Systemic Lupus Erythematosus (SLE)

edited by

Chang-Hee Suh

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2412 | Submission Open

Keywords: systemic lupus erythematosus; autoantibodies and biomarkers; lupus nephritis; new and novel treatments; targeted treatment or precision medicine; quality of life

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Implications of Pupil Function: Optical Quality, Visual Performance, and Neurological Biomarkers

edited by Pablo De Gracia and Héctor E. Soriano Baron

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2338 | Submission Open

Keywords: pupil function; visual performance; intraocular lens (IOL) optimization; pupillometry diagnostics; neuro-ophthalmic biomarkers

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnosis and Therapeutic Approaches for Acute and Chronic Coronary Syndromes

edited by Rocco Antonio Montone

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2297 | Submission Open

Keywords: coronary artery disease; clinical diagnosis; therapeutic approaches; atherosclerosis; risk factors; percutaneous cor-onary intervention; acute coronary syndrome; MINOCA; INOCA

(This special issue belongs to the Section Cardiology)

Thrombosis and Haemostasis: Clinical Advances

edited by Hui Yin Lim

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2247 | Submission Open

Keywords: venous thrombosis; biomarkers; bleeding; direct oral anticoagulants; pulmonary embolism; factor XI inhibitors; factor XII inhibitors; endovascular treatment

(This special issue belongs to the Section Vascular Medicine)

Lung Transplantation: Clinical Advances and Practice Updates

edited by Milton Saute

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2181 | Submission Open

Keywords: lung transplantation; respiratory failure; thoracic surgery; cardiothoracic surgery; solid organ transplantation; immunosuppression; lung cancer

(This special issue belongs to the Section Respiratory Medicine)

Diagnosis and Surgical Treatment for Colorectal Cancer

edited by Nidal Issa, Wisam Khoury and Rachel Gingold-Belfer

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2032 | Submission Open

Keywords: colorectal cancer; laparoscopy; colonoscopy; colectomy; diagnosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Systemic Autoimmune Disorder with Pulmonary Involvement: Novel Insights from Underlying Mechanisms of Drug Development and Intervention

edited by

Fabio Perrotta

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1973 | Submission Open

Keywords: rheumatic diseases; pulmonary involvement; connective tissue disorders; systemic autoimmune disorders (SARDs); diagnosis; innovative treatments

(This special issue belongs to the Section Respiratory Medicine)

Current Challenges and New Perspectives in Liver Transplantation

edited by

Anna Mrzljak

and

Quirino Lai

submission deadline 20 Mar 2026 | 3 articles | Viewed by 1953 | Submission Open

Keywords: liver transplantation; graft survival; immunosuppression; organ allocation; hepatocellular carcinoma; MASLD; donor shortage; transplant outcomes; innovation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Acute Hypoxemic Respiratory Failure: Progress, Challenges and Future

edited by

Davide Alberto Chiumello

and

Jesús Villar

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1860 | Submission Open

Keywords: ARDS; artificial intelligence; mechanical ventilation; non-invasive ventilation; lung imaging

(This special issue belongs to the Section Intensive Care)

Acute Ischemic Stroke Management Strategies

edited by

Marta Iacobucci

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1617 | Submission Open

Keywords: mechanical thrombectomy; leptomeningeal collateral circulation; neuroprotection; reperfusion injury; ischemic penumbra

(This special issue belongs to the Section Clinical Neurology)

Liquid Biopsies in Oral Cancer: Advances and New Perspectives

edited by

Óscar Rapado-González

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1578 | Submission Open

Keywords: oral cancer; oral potentially malignant disorders; liquid biopsies; saliva and blood biomarkers; circulating tumor cells (CTCs); cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA); cell-free RNA (cfRNA); extracellular vesicles (EVs); genetic and epigenetic biomarkers; early detection; prognosis and therapy response prediction; precision medicine

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Minimally Invasive Gynecologic Surgery: Optimizing Outcomes and Perioperative Strategies

edited by Raanan Meyer

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1537 | Submission Open

Keywords: minimally invasive gynecologic surgery; MIGS; laparoscopy; robotic surgery; endometrial cancer; endometriosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Developments of Oral and Maxillofacial Surgery

edited by

José María Martinez-Gonzalez

and

Natalia Martínez-Rodríguez

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1482 | Submission Open

Keywords: oral surgery; maxillofacial surgery; bone resorption; implant surgery; oral rehabilitation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Perspectives in Cardiac Imaging: How to See the Unseen

edited by

Adriana D'Antonio

and Wanda Acampa

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1392 | Submission Open

Keywords: cardiac imaging; MPI; PET; SPECT; CCTA; MR; CAD; heart failure; cardiac sarcoidosis; cardiac amyloidosis; valvular disease; artificial intelligence

(This special issue belongs to the Section Cardiology)

Cognitive Impairment, Dementia and Depression in Older Adults

edited by Seong Jae Kim and Ilhan Choo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1338 | Submission Open

Keywords: cognitive impairment; dementia; depression; Parkinson’ s disease; artificial intelligence (AI); predictive modeling

(This special issue belongs to the Section Geriatric Medicine)

Pancreatic Surgery: Clinical Practices and Challenges

edited by Guido Alsfasser and

Roberto Salvia

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1268 | Submission Open

Keywords: prognostic variables; surgical technique; outcome; timing of surgery; perioperative strategies; pancreatic cancer; pancreatitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Fresh Insights in Skin Disease

edited by

Claudio Marasca

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1166 | Submission Open

Keywords: inflammatory dermatoses; dermoscopy; melanoma; autoimmune skin conditions; psoriasis; skin cancers; skin syndromes

(This special issue belongs to the Section Dermatology)

Perspectives on the Diagnosis and Treatment of Cardiomyopathies

edited by Luca Arcari

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1037 | Submission Open

Keywords: cardiomyopathies; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac amyloidosis; arrhythmogenic right ventricular cardiomyopathy; non-dilated left ventricular cardiomyopathy; cardiac magnetic resonance imaging; computed tomography; echocardiography; nuclear imaging

(This special issue belongs to the Section Cardiology)

Minimally Invasive Surgery: Challenges and Solutions in Clinical Practice

edited by

Giuseppe Cavallaro

and Alessia Fassari

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1013 | Submission Open

Keywords: laparoscopic surgery; minimally invasive surgery; surgical challenges; clinical practice; surgical training; robotic-assisted surgery; artificial intelligence in surgery; laparoscopic instrumentation; intraoperative complications; surgical innovation; skill enhancement; surgical outcomes

(This special issue belongs to the Section General Surgery)

Clinical Advances in Obesity and Bariatric Surgery—2nd Edition

edited by Valentin Mocanu and Jerry Dang

submission deadline 20 Mar 2026 | 1 articles | Viewed by 985 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; anti-obesity medications; obesity treatment

(This special issue belongs to the Section Endocrinology & Metabolism)

New Advances in Clinical Epidemiological Research Methods

edited by

Dorota Sys

and Anna Scholz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 954 | Submission Open

Keywords: clinical epidemiology; research methodology; observational studies; causal inference; real-world data; machine learning; bias control

(This special issue belongs to the Section Clinical Research Methods)

Esophageal and Upper Interventional Endoscopy and Surgery: Latest Advances and Prospects

edited by Giulia Gibiino

submission deadline 20 Mar 2026 | 1 articles | Viewed by 861 | Submission Open

Keywords: gastric preneoplastic and neoplastic lesions; endoscopic submucosal dissection (ESD); endoscopic full-thickness resection (EFTR); subepithelial upper GI lesions; duodenal adenomas; esophageal stenting

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Maxillomandibular Growth, Reconstruction and Rehabilitation: Orthodontic, Prosthodontic and Surgical Interventions from Childhood to Adulthood

edited by Kamila Chęcińska and

Maciej Sikora

submission deadline 20 Mar 2026 | 1 articles | Viewed by 759 | Submission Open

Keywords: maxillomandibular growth; orthodontics; prosthodontics; surgical interventions; childhood; adulthood; reconstruction; rehabilitation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Autism Management

edited by

Justyna Podgórska-Bednarz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 730 | Submission Open

Keywords: autism spectrum disorder; diagnosis; child; adult; youth; early intervention; therapy; epidemiology; relatives; resources; limitations; problems; health; epidemiology; perspectives; organization

(This special issue belongs to the Section Mental Health)

Treatment Strategies for Prostate Cancer: An Update

edited by

Antonio Andrea Grosso

submission deadline 20 Mar 2026 | 1 articles | Viewed by 720 | Submission Open

Keywords: prostate cancer; robotic surgery; uro-oncology; focal therapy; single-port; radiotherapy

(This special issue belongs to the Section Nephrology & Urology)

Latest Advances in Minimally Invasive Spine Surgery

edited by Fabian Sommer and

Roger Härtl

submission deadline 20 Mar 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: minimally invasive spine surgery (MISS); advances in spine surgery; future directions of MISS; navigation and orientation; intramedullary/extramedullary tumor resections; emerging technologies in MISS (robotics; augmented reality; artificial intelligence; etc.); degenerative spine; patient safety in MISS

(This special issue belongs to the Section Clinical Neurology)

Innovations in Emergency and Critical Care Medicine

edited by Yoshiaki Iwashita

submission deadline 20 Mar 2026 | Viewed by 524 | Submission Open

Keywords: emergency; artificial intelligence; Tele-ICU; point of care; electrical impedance tomography

(This special issue belongs to the Section Intensive Care)

Pediatric Otolaryngology: Clinical Advances and Challenges

edited by

Manabu Komori

and

Masaomi Motegi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 480 | Submission Open

Keywords: pediatric dizziness; laryngomalacia; subglottic stenosis; pediatric airway obstruction; intracapsular tonsillectomy; PITA (Powered Intracapsular Tonsillectomy and Adenoidectomy); pediatric sleep-disordered breathing; pediatric olfactory disorders; congenital anosmia

(This special issue belongs to the Section Clinical Pediatrics)

Update on Minimally Invasive Gynecologic Surgery

edited by

Greg J. Marchand

submission deadline 20 Mar 2026 | 2 articles | Viewed by 468 | Submission Open

Keywords: minimally invasive gynecologic surgery (MIGS); obstetrics and gynecology; single-port laparoscopy; hysterectomy; robotic surgery

(This special issue belongs to the Section Obstetrics & Gynecology)

Challenges and Innovations in Thrombosis and Haemostasis

edited by Vasiliki Danilatou and Fotios I. Girtovitis

submission deadline 20 Mar 2026 | Viewed by 440 | Submission Open

Keywords: air pollution and thrombosis; antiphospholipid syndrome; antithrombotic therapy; arterial thrombosis; artificial intelligence in thrombosis and haemostasis; biology of arterial thrombosis; biomarkers in thrombosis and haemostasis; cancer-associated thrombosis; clinical decision support; current concepts and novel targets for antiplatelet treatments; digital health in heamostasis and thrombosis; endotheliopathy and thrombosis; ethical challenges in thrombosis care; hemophilia and von willebrand disease; innovative therapies in thrombosis and haemostasis; pediatric thrombosis; platelet biology and function: new concepts and clinical perspectives; rare blood disorders; thrombophilia; thrombosis and hemostasis guidelines; thrombosis in pregnancy; thrombo-inflammation; trauma-induced coagulopathy; venous thromboembolism

(This special issue belongs to the Section Vascular Medicine)

Advances in Diagnosis and Treatment of Endometriosis

edited by

Arrigo Fruscalzo

and

Anis Feki

submission deadline 20 Mar 2026 | 1 articles | Viewed by 386 | Submission Open

Keywords: endometriosis; adenomyosis; diagnosis; classification; therapy; progesterone

(This special issue belongs to the Section Obstetrics & Gynecology)

Recent Advances in Head and Neck Surgery

edited by Lisa Catarzi,

Olindo Massarelli

and

Guido Gabriele

submission deadline 20 Mar 2026 | Viewed by 384 | Submission Open

Keywords: head and neck surgery; reconstructive surgery; microsurgical reconstruction; new technologies; computer-assisted surgery; surgical innovation; post-operative care

(This special issue belongs to the Section Otolaryngology)

Vertigo and Dizziness in Children: Clinical Updates

edited by

Eduardo Martin Sanz

submission deadline 20 Mar 2026 | Viewed by 228 | Submission Open

Keywords: vertigo; dizziness; children; vestibular disorders; otorhinolaryngology

(This special issue belongs to the Section Clinical Pediatrics)

Up-to-Date Research on Nerve Ultrasound

edited by

Hubertus Axer

and Eman A. Tawfik

submission deadline 20 Mar 2026 | Viewed by 203 | Submission Open

Keywords: peripheral nerve ultrasound; polyneuropathy; nerve trauma; plexus neuritis; nerve tumors; entrapment syndromes; ultrasound techniques; guidelines

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Musculoskeletal Disorders: 2nd Edition

edited by

Peter V. Giannoudis

and Sushrut Babhulkar

submission deadline 20 Mar 2026 | Viewed by 196 | Submission Open

Keywords: musculoskeletal disorders; disability; pain; inflammation; arthritis

(This special issue belongs to the Section Clinical Rehabilitation)

Postpartum Depression: What Happened to My Wife?

edited by

Sara Albuquerque

, Ana Filipa Beato and

Stephanie Alves

submission deadline 20 Mar 2026 | Viewed by 188 | Submission Open

Keywords: postpartum depression; clinical and health psychology; perinatal trauma; clinical and health psychology; mental health and quality of life

(This special issue belongs to the Section Mental Health)

Modern Gynecological Surgery: Clinical Updates and Perspectives

edited by

Rudy Leon De Wilde

Harald Krentel

and Maya Sophie de Wilde

submission deadline 20 Mar 2026 | Viewed by 179 | Submission Open

Keywords: gynecological diseases; gynecological surgery; surgical options; individual treatment; women’ s health care

(This special issue belongs to the Section Obstetrics & Gynecology)

Contemporary Oral and Maxillofacial Surgery: Expert Consensus and Best Practices

edited by

Jae-Yeol Lee

submission deadline 20 Mar 2026 | Viewed by 163 | Submission Open

Keywords: facial trauma; TMJ disorders; implant and sinus surgery; sleep apnea; cosmetic and reconstructive surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Emerging Radiotherapy Technologies and Trends

edited by

Michele Fiore

submission deadline 20 Mar 2026 | Viewed by 161 | Submission Open

Keywords: image-guided radiotherapy (IGRT); 4D radiotherapy; SBRT; radiomics; FLASH therapy; MR-guided radiotherapy

(This special issue belongs to the Section Oncology)

Clinical Management in Chronic Pain: Innovations, Integration, and Interventions

edited by Giuliano Lo Bianco, Silvia Natoli and Sean Li

submission deadline 20 Mar 2026 | Viewed by 156 | Submission Open

Keywords: chronic pain; clinical management; interventional pain medicine; spinal cord stimulation; regenerative medicine; diagnostic strategies; pain semeiotics; multidisciplinary approaches; personalized medicine; pain assessment; neuromodulation; evidence-based pain therapy

(This special issue belongs to the Section Clinical Neurology)

Rehabilitation in Musculoskeletal Disease

edited by

Youngsook Bae

submission deadline 20 Mar 2026 | Viewed by 154 | Submission Open

Keywords: musculoskeletal disease; stroke rehabilitation; physical therapy; rehabilitation; chronic pain; manual therapy; exercise intervention

(This special issue belongs to the Section Clinical Rehabilitation)

Minimally Invasive and Endoscopic Neurosurgery

edited by

Nikolaos Gkantsinikoudis

, Vassilios Tsitouras and Stylianos Kapetanakis

submission deadline 20 Mar 2026 | 1 articles | Viewed by 152 | Submission Open

Keywords: traumatic brain injury; neuro-oncology; hydrocephalus and cerebrospinal fluid disorders; neuroendoscopy; endo-scopic neurosurgery; skull base surgery; vascular neurosurgery; functional neurosurgery; pediatric neurosurgey; minimally invasive spine surgery; endoscopic spine surgery; spine endoscopy

(This special issue belongs to the Section Clinical Neurology)

Recent Advances in Vitreoretinal Surgery: 2nd Edition

edited by

Lihteh Wu

submission deadline 20 Mar 2026 | Viewed by 149 | Submission Open

Keywords: vitrectomy; retinal detachment; macular holes; pediatric vitreoretinal surgery; vitrectomy instrumentation; macular surgery; complex retinal detachments; vitreoretinal surgery

(This special issue belongs to the Section Ophthalmology)

Periodontitis and Systemic Health: Exploring the Oral-Systemic Connection

edited by

Yiorgos Bobetsis

and Phoebus Madianos

submission deadline 20 Mar 2026 | Viewed by 136 | Submission Open

Keywords: periodontal disease; systemic diseases; cardiovascular disease; diabetes mellitus; adverse pregnancy outcomes; respiratory disease; neurodegenerative disorders; obesity; respiratory diseases; chronic kidney disease

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Prosthetic Joint Infection

edited by

Mattia Loppini

submission deadline 20 Mar 2026 | Viewed by 136 | Submission Open

Keywords: total hip revision; total knee revision; complications; periprosthetic joint infections; diagnostics

(This special issue belongs to the Section Orthopedics)

Advances in the Field of Radiation Oncology: An Update

edited by