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Pancreatic Surgery: Clinical Practices and Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 640

Special Issue Editors

*
E-Mail Website
Guest Editor
Department of General, Visceral, Thoracic, Vascular and Transplantation Surgery, University of Rostock, Rostock, 18057, Germany
Interests: pancreatic surgery; visceral surgery; pancreatic carcinoma; cystic tumors
* FACS

E-Mail Website
Guest Editor
University of Verona, Unit of General and Pancreatic Surgery, G.B. Rossi Hospital, P.Le L.A. Scuro 10, 37134 Verona, Italy
Interests: pancreatic surgery; IPMN; pancreatic carcinoma; cystic tumors

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue about new insights in pancreatic surgery. Pancreatic surgery is as demanding as the diseases of the pancreas itself. This Special Issue will cover different aspects of managing pancreatic diseases such as acute pancreatitis, chronic pancreatitis and pancreatic carcinoma. In every aspect, the outcomes of pancreatic surgery have improved over the last decades; however, many challenges still exist and clinical practice has been adapted over the last years based on intensive research in this field.

Hence, we are looking for new aspects and reports about prognostic variables, preoperative assessment, surgical techniques, perioperative strategies or outcomes in the treatment of pancreatic diseases.

We encourage you to submit any article type supported by this journal.

We are looking forward to your submissions to this Special Issue.

Dr. Guido Alsfasser
Prof. Roberto Salvia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prognostic variables
  • surgical technique
  • outcome
  • timing of surgery
  • perioperative strategies
  • pancreatic cancer
  • pancreatitis

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Published Papers (1 paper)

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Research

13 pages, 1713 KiB  
Article
Adjuvant Chemotherapy Is Associated with Improved Survival in Advanced Ampullary Adenocarcinoma—A Population-Based Analysis by the German Cancer Registry Group
by Jannis Duhn, Julia Strässer, Lennart von Fritsch, Rüdiger Braun, Kim C. Honselmann, Markus Kist, Thaer S. A. Abdalla, Kees Kleihues-van Tol, Bianca Franke, Fabian Reinwald, Andrea Sackmann, Bernd Holleczek, Anna Krauß, Monika Klinkhammer-Schalke, Sylke R. Zeissig, Steffen Deichmann, Tobias Keck, Ulrich F. Wellner and Louisa Bolm
J. Clin. Med. 2025, 14(11), 3869; https://doi.org/10.3390/jcm14113869 - 30 May 2025
Viewed by 360
Abstract
Introduction: Ampullary adenocarcinomas (AMPACs) represent rare malignant neoplasms arising in the Ampulla of Vater. Due to a lack of prospective studies and heterogeneous results from retrospective analyses, the outcomes of adjuvant chemotherapy (AC) in AMPAC are unclear. Methods: Pooled, pseudonymized data [...] Read more.
Introduction: Ampullary adenocarcinomas (AMPACs) represent rare malignant neoplasms arising in the Ampulla of Vater. Due to a lack of prospective studies and heterogeneous results from retrospective analyses, the outcomes of adjuvant chemotherapy (AC) in AMPAC are unclear. Methods: Pooled, pseudonymized data were retrieved from clinical cancer registries participating in the German Cancer Registry Group of the Association of German Tumor Centers (GCRG/ADT). Patients who underwent surgical resection of AMPACs (ICD-10: C24.1) with subsequent follow-up or AC were included. Patients with 90-day postoperative mortality were excluded. The epidemiologic and histopathologic features as well as the overall survival and recurrences were compared in both groups using R statistics. Results: In total, 830 patients with AMPACs were identified, of which 184 (22.2%) received AC. The surgery + AC patients showed more advanced tumor stages and more pronounced locoregional invasion as compared to the group undergoing surgery alone. AC was independently associated with an improved overall survival (OS) in a multivariable analysis (HR 0.57, p < 0.001), where pT3-4 status, lymph node metastases, vascular invasion, and advanced grading remained independent prognostic factors for OS. In the subgroup analyses, AC was associated with improved OS in the patients with pT3-4 tumors, lymph node metastases, lymphovascular invasion, and advanced grading, or UICC stage III, whereas no association with the OS was observed in the other subgroups. AC was also associated with superior disease-free survival (DFS) in a multivariable analysis. Conclusions: We provide a large-scale population-based analysis of AMPAC patients, showing an association of AC with improved OS in patients with advanced-staged disease or signs of locoregional invasion as compared to surgery alone. Full article
(This article belongs to the Special Issue Pancreatic Surgery: Clinical Practices and Challenges)
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