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Advances in Diagnosis and Treatment of Endometriosis
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Advances in Diagnosis and Treatment of Endometriosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1144

Special Issue Editors

Prof. Dr. Arrigo Fruscalzo

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Cantonal Hospital Fribourg, 1708 Fribourg, Switzerland
Interests: endometriosis; elasticity imaging technology; pregnancy complications
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Anis Feki

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Hôpital Fribourgeois, Fribourg, Switzerland
Interests: embryonic stem cells; induced pluripotent stem cells; developmental biology; disease modeling; neurodegenerative diseases; neurodevelopmental diseases; 2D and 3D cellular models; organoids; co-culture cellular systems; drug screening; personalized medicine; cellular replacement therapy and regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis is one of the most common gynecological pathologies. Despite its benign nature, it is linked to extensive clinical, social, and health financial burden, mainly due to its elusiveness and chronic pathway of development. Even so current research efforts, diagnosis and treatment options remain challenging. Thus, a prominent research area exists to be explored with the expectation of improving the way we approach and treat this disease.

In the past Special Issue (https://www.mdpi.com/journal/jcm/special_issues/O71E5E0N2A), we provided a collection of nine manuscripts covering various relevant topics related to endometriosis, ranging from psychological and mental health issues to the main topic of infertility concerns in endometriosis as a chronic disease, finally also addressing research on an immunologic fingerprint common to endometriosis-related comorbidities.

This new Special Issue aims to provide an overview of the current knowledge of endometriosis. This should cover all main issues of both endometriosis and adenomyosis, including diagnosis, classification systems, and conservative and surgical therapies for pain and infertility concerns. Manuscripts approaching less common topics, such as endometriosis during adolescence and menopause, extra-pelvic endometriosis, primary and secondary prevention strategies, new non-invasive diagnostic approaches, and new therapies are warmly encouraged. We welcome both original research articles and reviews.

Prof. Dr. Arrigo Fruscalzo
Prof. Dr. Anis Feki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • adenomyosis
  • diagnosis
  • classification
  • therapy
  • progesterone

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Related Special Issue

Published Papers (2 papers)

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Research

12 pages, 366 KB  
Article
Non-Invasive Diagnosis of Endometriosis by Questionnaires in Patients Using Contraception
by Felix Zeppernick, Samira Balimuttajjo, Christian Schorr, Florian Sibelius, Manuela Schuler, Sebastian Harth, Sarah Seeger, Anna Löffelmann, Muhammad A. Riaz, Ivo Meinhold-Heerlein and Lutz Konrad
J. Clin. Med. 2026, 15(1), 30; https://doi.org/10.3390/jcm15010030 - 20 Dec 2025
Viewed by 317
Abstract
Background/Objectives: The assessment of endometriosis (EMS)-associated pain is important, but only very few studies address the potential use of questionnaires for non-invasive prediction of the disease. Methods: In a prospective observational study from 2016 to 2024 with patients (n = 228) using hormonal [...] Read more.
Background/Objectives: The assessment of endometriosis (EMS)-associated pain is important, but only very few studies address the potential use of questionnaires for non-invasive prediction of the disease. Methods: In a prospective observational study from 2016 to 2024 with patients (n = 228) using hormonal contraception, all women with suspected EMS answered two questionnaires and were examined physically and with transvaginal ultrasound (TVUS). If deep infiltrating EMS (DIE) was suspected, magnetic resonance imaging (MRI) was performed. EMS diagnosis was confirmed by histological examination. Statistical analysis was mainly performed using 2 × 2 contingency tables. The decision tree was created manually. Results: The mean numerical rating scales (NRSs) of EMS-positive compared to EMS-negative patients were ~4-fold higher (4.45 and 1.15, respectively). Patients with EMS have, significantly, ~3 times more significant parameters compared to patients without EMS (18.5 and 5.9, respectively). In combination with dysuria and lightning-like pain, this resulted in very good prediction. A decision tree yielded a sensitivity of 0.924, a specificity of 0.917, a positive predictive value (PPV) of 0.924, a negative predictive value (NPV) of 0.917, and a positive likelihood ratio of 11.2, indicating a very good diagnostic test. There is no typical endometriosis pain, but various pain patterns are predictive of EMS. Conclusions: Thus, a reliable non-invasive EMS diagnosis by questionnaires is possible and could reduce the delay in the detection of EMS. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Endometriosis)
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28 pages, 14273 KB  
Article
Adenomyosis-Modern Techniques for Ultrasound and Histo-Pathological Diagnosis of the Endo-Myometrial Junction Zone Changes
by Elena Iuliana Anamaria Berbecaru, George-Lucian Zorilă, Anca-Maria Istrate-Ofiţeru, Gabriela-Camelia Roșu, Elvira Brătilă, Daniel Pirici, Cristina Jana Busuioc, Laurențiu Mogoantă, Răzvan Grigoraș Căpitănescu, Dominic-Gabriel Iliescu and Marian Valentin Zorilă
J. Clin. Med. 2025, 14(24), 8744; https://doi.org/10.3390/jcm14248744 - 10 Dec 2025
Viewed by 629
Abstract
Background/Objectives: Adenomyosis (A) is a benign but invasive uterine condition frequently associated with structural changes in the uterine wall that may contribute to infertility. Methods: This is a retrospective study involving 140 patients: 100 diagnosed with primary infertility (PI) or secondary [...] Read more.
Background/Objectives: Adenomyosis (A) is a benign but invasive uterine condition frequently associated with structural changes in the uterine wall that may contribute to infertility. Methods: This is a retrospective study involving 140 patients: 100 diagnosed with primary infertility (PI) or secondary infertility (SI) and 40 in the control group. All patients were assessed using transvaginal two-dimensional, three-dimensional, and hysterosalpingo-contrast sonography (HyCoSy), performed in the early proliferative phase. Evaluated parameters included uterine dimensions, endometrial thickness, and characteristics of the junctional zone (JZ). Criteria such as JZmax > 5 mm or JZmax − JZmin > 5 mm, alongside other findings, supported the diagnosis of adenomyosis. Results: Patients with PI showed larger uterine longitudinal diameters, while SI patients had thicker JZ measurements. PI patients were significantly younger. Histopathological examination confirmed the presence of endometrial glands and periglandular stroma disrupting myometrial architecture, forming chronic lesions potentially linked to infertility. Conclusions: HyCoSy revealed variable depths of myometrial invasion by A, with some cases extending near the serosa. The chronic lesions found in histopathological examination were potentially linked to infertility. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Endometriosis)
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