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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Biomarkers and Treatment Strategies for Gastrointestinal Malignancies: From the Bench to the Bedside submission deadline 26 Nov 2026 | Viewed by 249 | Submission Open
Keywords: gastrointestinal (GI) malignancies; medical oncology; immunotherapy; biomarkers; target therapies
(This special issue belongs to the Section Oncology)
Life-Threatening Conditions in Pediatric Patients: Clinical Challenges and Emergency Management Strategies
edited by , Piotr Konrad Leszczyński, Alina Minarowska and
submission deadline 27 Nov 2026 | Viewed by 1365 | Submission Open
Keywords: child; pediatrics; pediatric emergencies; injuries; illnesses; clinical intervention; emergency treatment; acute care; life-threatening condition; therapeutic outcome
(This special issue belongs to the Section Emergency Medicine)
Rehabilitation Strategies for Neurological Disorders: Advances and Insights
edited by Delia Cinteză and Mihai Berteanu
submission deadline 30 Nov 2026 | 8 articles | Viewed by 16906 | Submission Open
Keywords: neurorehabilitation; physical medicine; virtual reality; AI in rehabilitation medicine; robotic rehabilitation; telerehabilitation; advanced technologies; upper neuromotor lesions; peripheral neuropathies; wearable sensor devices; assessment; goal-setting; individual rehabilitation plan
(This special issue belongs to the Section Clinical Rehabilitation)
Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition submission deadline 30 Nov 2026 | 4 articles | Viewed by 14648 | Submission Open
Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery
(This special issue belongs to the Section Otolaryngology)
Reducing Modifiable Risk Factors to Prevent and Control Non-Communicable Diseases: 2nd Edition submission deadline 30 Nov 2026 | 4 articles | Viewed by 3659 | Submission Open
Keywords: non-communicable disease; chronic disease; cardiovascular disease; cancer; chronic respiratory disease; diabetes; mental health; tobacco use; physical inactivity; unhealthy diet; alcohol use; disease prevention
(This special issue belongs to the Section Epidemiology & Public Health)
Current Challenges and Updates in Therapeutic Advancements of Prostatectomy submission deadline 30 Nov 2026 | 2 articles | Viewed by 1535 | Submission Open
Keywords: radical prostatectomy; robot-assisted surgery; single port; artificial intelligence; complications; same day discharge; learning curve; training models; outcomes
(This special issue belongs to the Section Nephrology & Urology)
Metastatic Colorectal Cancer Beyond Second-Line Treatment
edited by Jacopo Giuliani
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1461 | Submission Open
Keywords: metastatic colorectal cancer; subsequent lines; chemotherapy; targeted agents; radiotherapy; local therapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Advances in Clinical Therapeutic Methods of Kidney Stone submission deadline 30 Nov 2026 | 1 articles | Viewed by 1230 | Submission Open
Keywords: retrograde intrarenal surgery; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques
(This special issue belongs to the Section Nephrology & Urology)
Current Advances and Future Perspectives in Cardiothoracic Surgery
edited by Tomislav Kopjar
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1218 | Submission Open
Keywords: cardiothoracic surgery; minimally invasive techniques; robotic-assisted surgery; personalized therapy; surgical innovation; prosthetic devices; perioperative management; transplantation; technological advances; postoperative care; surgical outcomes; future perspectives; healthcare disparities
(This special issue belongs to the Section General Surgery)
From Imaging to Impact: Improving Breast Cancer Diagnosis and Outcomes
edited by Dana Samir Al-Mousa and Kelly Bentley-Spuur
submission deadline 30 Nov 2026 | 2 articles | Viewed by 973 | Submission Open
Keywords: breast cancer diagnosis; breast imaging; breast cancer screening; screening mammography; diagnostic breast imag-ing; breast density assessment; early detection of breast cancer; breast imaging innovation; diagnostic accuracy in breast imaging; artificial intelligence in breast imaging; radiation dose optimisation in breast imaging; image quality in breast imaging; clinical implementation of breast imaging technologies; patient outcomes in breast cancer care; health system efficiency in breast imaging
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Interventional Treatment of Coronary Artery Disease: Clinical Insights and Current Practice
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 967 | Submission Open
Keywords: percutaneous coronary intervention (PCI); coronary artery disease (CAD); complex coronary intervention; physiology-guided revascularization (FFR/iFR); post-PCI Integrated non-pharmacological therapies; intravascular imaging (IVUS/OCT); severe coronary calcification; personalized antiplatelet therapy; spontaneous coronary artery dissection; high bleeding risk; drug-coated balloons; artificial intelligence in interventional cardiology
(This special issue belongs to the Section Cardiology)
New Insights into Sports Injuries and Rehabilitation: From Injury to Performance submission deadline 30 Nov 2026 | 1 articles | Viewed by 938 | Submission Open
Keywords: sports medicine; sports injuries; orthopedic rehabilitation; upper limb injuries; tendon and ligament injuries; return to sport; injury prevention; regenerative therapies
(This special issue belongs to the Section Sports Medicine)
The Use of Artificial Intelligence in Cancer Research, Diagnosis, and Care
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 574 | Submission Open
Keywords: artificial intelligence; oncology; cancer diagnosis; prognostic modeling; clinical validation; digital twins
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Cruciate Ligament Injuries in Sport Medicines: Diagnosis, Treatment and Rehabilitation
edited by
submission deadline 30 Nov 2026 | Viewed by 317 | Submission Open
Keywords: cruciate ligament; sport medicine; trauma; meniscus; knee instability; anterior cruciate ligament reconstruction; posterior cruciate ligament; rehabilitation; return to sport; injury prevention
(This special issue belongs to the Section Sports Medicine)
Targeted Management and Diagnosis of Rheumatoid Arthritis submission deadline 30 Nov 2026 | Viewed by 226 | Submission Open
Keywords: rheumatoid arthritis; difficult-to-treat rheumatoid arthritis; erosive arthritis; JAK inhibitors; biological drugs; window-of-opportunity
(This special issue belongs to the Section Immunology & Rheumatology)
Sjogren’s Syndrome: Clinical Advances and Insights
edited by David A. Isenberg
submission deadline 7 Dec 2026 | 10 articles | Viewed by 16903 | Submission Open
Keywords: xerostomia; xerophthalmia; non-Hodgkins lymphoma; autoimmune rheumatic diseases; Sjogren’s syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Placental Dysfunction and Cardiovascular Maternal Risk-Timing Assessment and Postpartum Challenges
edited by , Anca Huniadi and
submission deadline 8 Dec 2026 | Viewed by 308 | Submission Open
Keywords: cardiovascular risk; pre-eclampsia; fetal growth restriction; placental dysfunction; cardiac function; biomarkers
(This special issue belongs to the Section Obstetrics & Gynecology)
The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases
edited by
submission deadline 10 Dec 2026 | 4 articles | Viewed by 13457 | Submission Open
Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function
(This special issue belongs to the Section Cardiology)
Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction
edited by
submission deadline 10 Dec 2026 | 8 articles | Viewed by 11012 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; multimodal analgesia; postoperative analgesia; chronic pain management; opioid-sparing strategies; non-opioid analgesics; patient satisfaction; anesthesia techniques; perioperative care; pain interventions; nerve block techniques; clinical outcomes
(This special issue belongs to the Section Anesthesiology)
Obstructive Sleep Apnea: Advances and Challenges in Diagnosis, Phenotyping, and Clinical Impact
edited by , Muna Irfan and Andrew Namen
submission deadline 10 Dec 2026 | 3 articles | Viewed by 4361 | Submission Open
Keywords: obstructive sleep apnea; sleep diagnostics; screening tools; pulse oximetry; polysomnography; home sleep apnea testing; diagnostic accuracy; phenotyping; cardiometabolic comorbidity; neuropsychiatric outcomes; sleep -disordered breathing; real-world implementation
(This special issue belongs to the Section Respiratory Medicine)
New Clinical Advances in Pediatric Asthma
edited by
submission deadline 10 Dec 2026 | 3 articles | Viewed by 4140 | Submission Open
Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life
(This special issue belongs to the Section Clinical Pediatrics)
Prevention and Management of Sexual Dysfunction submission deadline 10 Dec 2026 | 3 articles | Viewed by 3134 | Submission Open
Keywords: sexual health; sexual dysfunction; reproductive health; general sexuology; sexological care
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Translational Immunology in Clinical Medicine: From Preclinical Insights to Therapeutic Impact
edited by
submission deadline 10 Dec 2026 | 2 articles | Viewed by 2396 | Submission Open
Keywords: translational immunology; autoimmune disease; autoinflammatory disease; immune-mediated diseases; oncology; preclinical models; immune efficacy and safety; mechanism of action; immunotoxicity assessment
(This special issue belongs to the Section Immunology & Rheumatology)
Breaking Barriers in Respiratory Conditions: From Clinical Pathophysiology to Treatment Across the Spectrum of Severity
edited by
submission deadline 10 Dec 2026 | 1 articles | Viewed by 1277 | Submission Open
Keywords: pulmonary rehabilitation; skeletal muscle; exercise physiology; exercise intolerance; physical activity; respiratory conditions
(This special issue belongs to the Section Respiratory Medicine)
Clinical Rehabilitation and Management of Chronic Musculoskeletal Pain Conditions
edited by
submission deadline 10 Dec 2026 | 2 articles | Viewed by 830 | Submission Open
Keywords: reproducibility of results; rehabilitation; physical therapy; artificial intelligence; machine learning; musculoskeletal system; treatment outcome
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Cosmetic Dermatology: From Health to Aesthetics and Restoring Confidence
edited by
submission deadline 10 Dec 2026 | 1 articles | Viewed by 644 | Submission Open
Keywords: aesthetic dermatology; cosmetic dermatology; energy-based devices; dermal fillers; botulinum toxin; biostimulators; skin rejuvenation; regenerative medicine; scar treatment; hair disorders; pigmentary disorders
(This special issue belongs to the Section Dermatology)
Cesarean Section Versus Vaginal Delivery submission deadline 10 Dec 2026 | Viewed by 558 | Submission Open
Keywords: cesarean section; vaginal delivery; birth outcomes; birth complications; delivery mode; labor process; obstetric care; trial of labor after cesarean (TOLAC); intrapartum care; obstetric decision-making
(This special issue belongs to the Section Obstetrics & Gynecology)
The Current Trend in the Management of Bruxism and Temporomandibular Disorders, 2nd Edition submission deadline 10 Dec 2026 | Viewed by 500 | Submission Open
Keywords: bruxism; temporomandibular disorders (TMDs); dental health; treatment modalities; diagnosis; clinical interventions
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Contemporary Advances in Esophageal and Upper Gastrointestinal Surgery
edited by and Carlo Castoro
submission deadline 10 Dec 2026 | Viewed by 321 | Submission Open
Keywords: esophageal surgery; gastric surgery; upper gastrointestinal cancer; minimally invasive surgery; robotic surgery; artificial intelligence; radiomics; neoadjuvant therapy; surgical quality assessment; fluorescence-guided surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Management of Advanced Ovarian Cancer: From Cytoreduction to Targeted Treatment
edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis
submission deadline 10 Dec 2026 | Viewed by 196 | Submission Open
Keywords: ovarian cancer; cytoreduction; HIPEC; targeted therapies; post-operative complications
(This special issue belongs to the Section Obstetrics & Gynecology)
Hospital-Acquired Infections: Epidemiology, Prevention, Treatment, and Organizational and Clinical Challenges
edited by and Jarosław Drobnik
submission deadline 10 Dec 2026 | Viewed by 130 | Submission Open
Keywords: hospital-acquired infections; healthcare-associated infections; nosocomial infections; epidemiology; infection prevention and control; antimicrobial resistance; antimicrobial stewardship; patient safety
(This special issue belongs to the Section Epidemiology & Public Health)
Updates in Gynecologic Surgery
edited by and Giulio Sozzi
submission deadline 13 Dec 2026 | Viewed by 235 | Submission Open
Keywords: gynecologic surgery; minimally invasive surgery (MIS); robotic-assisted surgery; vNOTES; endometriosis; pelvic organ prolapses
(This special issue belongs to the Section Obstetrics & Gynecology)
Diagnosis and Treatment Strategies for Endometriosis: Evidence and Practice
edited by and Carlo Alviggi
submission deadline 14 Dec 2026 | Viewed by 161 | Submission Open
Keywords: endometriosis; ultrasound; fertility preservation; ovarian stimulation; cryopreservation
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Trends and Future Prospects in Autoantibodies in Liver Diseases
edited by Takashi Himoto
submission deadline 15 Dec 2026 | 3 articles | Viewed by 10068 | Submission Open
Keywords: liver-specific autoantibodies; non-organ-specific autoantibodies; autoimmune liver disease; diagnosis; disease activity; treatment outcome; prognosis; virus-induced autoimmunity; drug-induced autoimmunity
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management submission deadline 15 Dec 2026 | 5 articles | Viewed by 4351 | Submission Open
Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Interventional Cardiology: Recent Developments and Future Challenges
edited by and George Kassimis
submission deadline 15 Dec 2026 | 3 articles | Viewed by 3301 | Submission Open
Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS, OCT); coronary physiology (FFR, iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)
(This special issue belongs to the Section Cardiology)
Clinical Advances in Cancer Imaging submission deadline 15 Dec 2026 | 3 articles | Viewed by 3296 | Submission Open
Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging
(This special issue belongs to the Section Oncology)
Surgical Treatment for Lung Cancer—2nd Edition
edited by , Cezary Piwkowski and Marek Ochman
submission deadline 15 Dec 2026 | 1 articles | Viewed by 770 | Submission Open
Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; enhanced recovery after surgery; segmentectomy
(This special issue belongs to the Section Respiratory Medicine)
Clinical Outcomes and Emerging Strategies in Neovascualr Age-Related Macular Degeneration submission deadline 15 Dec 2026 | Viewed by 483 | Submission Open
Keywords: neovascular age-related macular degeneration; exudative retinal disease; anti-VEGF therapy; tyrosine kinase inhibitors; angiopoietin/Tie-2 modulation; gene therapy; sustained-release platforms; complement pathway inhibition; real-world clinical outcomes
(This special issue belongs to the Section Ophthalmology)
Integrating Mental Health Into Chronic Illness Care: Interdisciplinary Clinical Strategies submission deadline 15 Dec 2026 | Viewed by 233 | Submission Open
Keywords: clinical psychology; psychosomatic medicine; assessment; chronic illness; mental health; patient-centred care
(This special issue belongs to the Section Mental Health)
Coronary CT Angiography, Cardiac MRI and PET/CT Scan: Advancing Cardiac Imaging and Clinical Decision Making in Cardiomyopathies submission deadline 15 Dec 2026 | Viewed by 229 | Submission Open
Keywords: coronary CT angiography; cardiac magnetic resonance imaging; cardiac positron emission tomography; cardiac imaging; cardiomyopathies; cardiac amyloidosis; cardiac sarcoidosis; hypertrophic cardiomyopathy; dilated cardiomyopathy; non-dilated left ventricular cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; restrictive cardiomyopathy; risk stratification; clinical decision making; artificial intelligence; radiomics
(This special issue belongs to the Section Cardiology)
Inherited Cardiac Disorders in Pediatrics: Present Challenges and Future Innovations
edited by Sara Moscatelli, and
submission deadline 15 Dec 2026 | Viewed by 228 | Submission Open
Keywords: paediatric cardiomyopathy; inherited cardiac diseases; cardiomyopathies; cardiovascular genetics; arthropathies; channelopathies
(This special issue belongs to the Section Cardiology)
Self-Injurious Thoughts and Behaviors: Risk, Mechanisms, and Clinical Intervention
edited by
submission deadline 15 Dec 2026 | Viewed by 225 | Submission Open
Keywords: self-injurious thoughts and behaviors; suicide; suicidal ideation; suicide attempts; non-suicidal self-injury; NSSI; self-harm; emotion dysregulation; trauma; risk factors; resilience; prevention; clinical intervention; adolescents; young adults
(This special issue belongs to the Section Mental Health)
Clinical Advances in Cardiac Arrhythmias and Electrophysiology
edited by Giovanni Volpato and
submission deadline 15 Dec 2026 | Viewed by 200 | Submission Open
Keywords: atrial fibrillation; conduction system pacing; ablation; ventricular tachycardia; electroanatomical mapping; endomyocardial biopsy
(This special issue belongs to the Section Cardiology)
Advances in Monitoring and Optimization of Non-Invasive Respiratory Support in Acute and Chronic Respiratory Failure
edited by and Teresa Renda
submission deadline 15 Dec 2026 | Viewed by 183 | Submission Open
Keywords: acute and chronic respiratory failure; acute hypoxemic respiratory failure (AHRF); acute respiratory distress syndrome (ARDS); respiratory monitoring; respiratory drive; inspiratory effort; non-invasive ventilation (NIV); high-flow nasal cannula (HFNC); home ventilation; telemonitoring
(This special issue belongs to the Section Respiratory Medicine)
Beyond Survival: Precision, Innovation, and Lifelong Care in Congenital Heart Disease
edited by
submission deadline 15 Dec 2026 | Viewed by 182 | Submission Open
Keywords: congenital heart disease; adult congenital heart disease; lifespan care; precision medicine; advanced cardiac imaging; transcatheter interventions; neurodevelopmental outcomes; arrhythmia management; digital health and artificial intelligence
(This special issue belongs to the Section Cardiology)
Gynecologic Oncology: Current Therapies and New Frontiers
edited by Laura Paleari and Mariangela Rutigliani
submission deadline 18 Dec 2026 | 1 articles | Viewed by 1508 | Submission Open
Keywords: ovarian cancers; gynecological cancer; drug delivery; AI; screening; new therapies
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Rhinitis and Sinusitis: Diagnosis, Therapy and Multimorbidity Management
edited by , and Veronica Seccia
submission deadline 18 Dec 2026 | 2 articles | Viewed by 1359 | Submission Open
Keywords: allergy; asthma; biologics; chronic rhinosinusitis; chronic rhinosinusitis with nasal polyps; endoscopic sinus surgery; NSAID-ERD; olfaction; personalized treatment; precision medicine; quality of life; respiratory disease; rhinitis; sinusitis; type-2 inflammation
(This special issue belongs to the Section Otolaryngology)
Evidence-Based Diagnosis and Clinical Management of Low Back Pain submission deadline 20 Dec 2026 | 6 articles | Viewed by 14084 | Submission Open
Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care
(This special issue belongs to the Section Clinical Rehabilitation)
Scoliosis: Advances in Diagnosis and Management
edited by Michal Latalski
submission deadline 20 Dec 2026 | 8 articles | Viewed by 13100 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; adult scoliosis; congenital scoliosis; neuromuscular scoliosis; diagnosis; imaging; treatment; surgery; bracing; rehabilitation; patient-reported outcomes; quality of life
(This special issue belongs to the Section Orthopedics)
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