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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diabetes Mellitus and Emerging Health Challenges: A Multidisciplinary Perspective
edited by Katarzyna A. Majewska and
submission deadline 15 Feb 2027 | 10 articles | Viewed by 16958 | Submission Open
Keywords: diabetes mellitus; type 1 diabetes; type 2 diabetes; diabetic complications; prediabetes; diabetes treatment; autoimmune diabetes
(This special issue belongs to the Section Endocrinology & Metabolism)
Periodontal Diseases and Systemic Health: Pathogenesis, Prevention and Management
edited by
submission deadline 15 Feb 2027 | 8 articles | Viewed by 13739 | Submission Open
Keywords: periodontitis; dental implants; systemic inflammation; diabetes and periodontal disease; cardiovascular implications; pregnancy and oral health; host immune responses; preventive dentistry; implant-prosthetic rehabilitation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Gynecological Diseases (Second Edition)
edited by
submission deadline 15 Feb 2027 | 5 articles | Viewed by 6106 | Submission Open
Keywords: gynecology; women's health; mini-invasive surgery; laparoscopy; hysteroscopy; diagnostic imaging; gynecological oncology; endometriosis; new therapy; urogynecology; female healthcare
(This special issue belongs to the Section Obstetrics & Gynecology)
Thoracic Surgery: Current Practice and Future Directions: 2nd Edition
edited by
submission deadline 15 Feb 2027 | 4 articles | Viewed by 5458 | Submission Open
Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS
(This special issue belongs to the Section Respiratory Medicine)
Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies
edited by Claus Schildberg and Frank Meyer
submission deadline 15 Feb 2027 | 5 articles | Viewed by 4544 | Submission Open
Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Insights and Challenges into Cognitive and Mental Health in Older Adults
edited by
submission deadline 15 Feb 2027 | 1 articles | Viewed by 3639 | Submission Open
Keywords: clinical insights; cognitive and mental health; older adults; psychosomatic interventions; person-centered care
(This special issue belongs to the Section Mental Health)
Congenital Heart Diseases: Epidemiology, Treatment and Lifelong Support
edited by Sebastian Freilinger, , and Oliver Dewald
submission deadline 15 Feb 2027 | 5 articles | Viewed by 3344 | Submission Open
Keywords: congenital heart disease (CHD); adults with CHD; epidemiology; comorbidities; intervention; surgical treatment; psychological aspects; quality of life (QoL); risk factors; rehabilitation; health promotion; prevention; health literacy; physical activity; lifelong support
(This special issue belongs to the Section Cardiology)
Cardiovascular Disease Risk Assessment and Clinical Management submission deadline 15 Feb 2027 | 3 articles | Viewed by 2930 | Submission Open
Keywords: cardiovascular risk assessment; cardiovascular disease prevention; risk factor management; preventive cardiovascular medicine; conservative treatment; percutaneous coronary interventions; health communication strategies; public health intervention
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advancements in Foot and Ankle Surgery: 2nd Edition
edited by
submission deadline 15 Feb 2027 | 2 articles | Viewed by 1198 | Submission Open
Keywords: flat foot; hindfoot motion; diabetic foot; hallux valgus; foot infection; foot trauma
(This special issue belongs to the Section Orthopedics)
Current Challenges and Opportunities in Assisted Reproductive Technologies
edited by Andrea Milostić-Srb and
submission deadline 15 Feb 2027 | Viewed by 510 | Submission Open
Keywords: artificial reproductive technologies; ART; mental health effect on ART; IVF; AI in reproductive medicine
(This special issue belongs to the Section Obstetrics & Gynecology)
Patient Safety and Clinical Outcomes in Robotic-Assisted Microsurgery and Endoscopic Surgery
edited by Tetsuji Uemura
submission deadline 15 Feb 2027 | Viewed by 384 | Submission Open
Keywords: endoscopic surgery; reconstructive surgery; robotic-assisted microsurgery; advanced surgical technologies; patient safety
(This special issue belongs to the Section General Surgery)
Malocclusion: Orthodontic Treatment, Periodontal Health and Epidemiology
edited by Monika Elżbieta Machoy
submission deadline 15 Feb 2027 | Viewed by 134 | Submission Open
Keywords: malocclusion; orthodontic treatment; periodontal health; periodontology; gingival inflammation; reduced periodontal support; clear aligners; fixed appliances; alveolar bone; gingival phenotype; oral epidemiology; digital dentistry; CBCT; artificial intelligence; oral microbiome
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Dental Implantology: Clinical Updates and Perspectives—2nd Edition
edited by
submission deadline 16 Feb 2027 | 6 articles | Viewed by 13651 | Submission Open
Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentis-try; periimplantitis; peri-implant soft tissues
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Unraveling Myopia: Current Science, Clinical Impact, and Future Horizons
edited by Neeraj K Singh and Pablo De Gracia
submission deadline 19 Feb 2027 | 5 articles | Viewed by 15649 | Submission Open
Keywords: accommodation; contact lenses; ophthalmic lenses; myopia progression; epidemiology; myopia control interventions; pharmaceutical treatments; environmental and behavioral risk factors; imaging innovations in myopia
(This special issue belongs to the Section Ophthalmology)
Movement Analysis in Rehabilitation
edited by Paola Contessa
submission deadline 19 Feb 2027 | 4 articles | Viewed by 7079 | Submission Open
Keywords: clinical biomechanics; engineering methods; human movement; motor control; muscle force; musculoskeletal disorders; neuromuscular diseases; posture and balance; rehabilitation
(This special issue belongs to the Section Orthopedics)
A Holistic Approach to Management of Complications in Hemodialysis
edited by
submission deadline 19 Feb 2027 | 1 articles | Viewed by 762 | Submission Open
Keywords: hemodialysis; complications; holistic care management; quality of life; well-being malnutrition; hypotension; cardiovascular diseases; inflammation; vascular access
(This special issue belongs to the Section Nephrology & Urology)
Alzheimer’s Disease and Related Disorders: Recent Advances in Prevention, Diagnosis and Therapy submission deadline 20 Feb 2027 | 4 articles | Viewed by 15452 | Submission Open
Keywords: cognition; prodromal; Alzheimer’s; Alzheimer; dementia; mild cognitive impairment; mild decline in cognition; disease-modifying; amyloid; tau; neuroinflammation; biomarkers; neuroimaging; PET; PET/CT; PET/MRI
(This special issue belongs to the Section Clinical Neurology)
AI in Maternal Fetal Medicine and Perinatal Management
edited by Ariel Many
submission deadline 20 Feb 2027 | 8 articles | Viewed by 15132 | Submission Open
Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction
(This special issue belongs to the Section Obstetrics & Gynecology)
Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights submission deadline 20 Feb 2027 | 9 articles | Viewed by 13455 | Submission Open
Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors
(This special issue belongs to the Section Clinical Rehabilitation)
Ultrasound-Guided Biopsy of Gynecologic Tumors: Technique and Clinical Application
edited by and Alexandros Daponte
submission deadline 20 Feb 2027 | 1 articles | Viewed by 12165 | Submission Open
Keywords: ultrasound-guided biopsy; gynecologic tumors; ovarian cancer; biopsy technique; precision diagnosis; endometrial lesions
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome submission deadline 20 Feb 2027 | 6 articles | Viewed by 10781 | Submission Open
Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Sepsis: Clinical Advances and Practical Updates
edited by
submission deadline 20 Feb 2027 | 5 articles | Viewed by 8308 | Submission Open
Keywords: sepsis pathophysiology; host immune response; biomarkers for sepsis; early sepsis diagnosis; immunotherapy in sepsis; antimicrobial stewardship
(This special issue belongs to the Section Intensive Care)
Risk Factors in Neonatal Intensive Care submission deadline 20 Feb 2027 | 7 articles | Viewed by 8059 | Submission Open
Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity
(This special issue belongs to the Section Clinical Pediatrics)
Parkinson's Disease: Recent Advances in Diagnosis and Treatment submission deadline 20 Feb 2027 | 6 articles | Viewed by 7248 | Submission Open
Keywords: Parkinson’s disease; disease-modifying therapies; artificial intelligence; microbiome; alpha-synuclein; neuroimaging
(This special issue belongs to the Section Clinical Neurology)
Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders submission deadline 20 Feb 2027 | 4 articles | Viewed by 7238 | Submission Open
Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn
(This special issue belongs to the Section Nephrology & Urology)
Advances in the Personalized Management of Chronic Obstructive Pulmonary Disease (COPD)
edited by and Georgios Hillas
submission deadline 20 Feb 2027 | 6 articles | Viewed by 6659 | Submission Open
Keywords: artificial intelligence; biologics; biomarkers; diagnostics; oscillometry; COPD pharmacotherapy; imaging
(This special issue belongs to the Section Respiratory Medicine)
Rising Star: Advanced Physical Therapy and Expansion
edited by
submission deadline 20 Feb 2027 | 4 articles | Viewed by 5846 | Submission Open
Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach
(This special issue belongs to the Section Clinical Rehabilitation)
New Clinical Advances in Breast Reconstruction
edited by
submission deadline 20 Feb 2027 | 6 articles | Viewed by 5640 | Submission Open
Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Myopic Optic Neuropathy (MON) and Glaucomatous Optic Neuropathy (GON): Current Concepts and Clinical Implications
edited by
submission deadline 20 Feb 2027 | 5 articles | Viewed by 5398 | Submission Open
Keywords: myopic optic neuropathy; glaucomatous optic neuropathy; tilting; axonal transport; lamina cribrosa
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Scoliosis and Spinal Disorders: Diagnosis and Management
edited by Tejas Subramanian
submission deadline 20 Feb 2027 | 4 articles | Viewed by 5046 | Submission Open
Keywords: spine surgery; adult spinal deformity; frailty; sarcopenia; muscle health; postoperative recovery; patient-reported outcomes
(This special issue belongs to the Section Orthopedics)
Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation submission deadline 20 Feb 2027 | 3 articles | Viewed by 5033 | Submission Open
Keywords: retinal diseases; macular degeneration; maculopathies; diabetic retinopathy; retinal vascular occlusions; retinitis pigmentosa
(This special issue belongs to the Section Ophthalmology)
Innovations in Neurorehabilitation—2nd Edition
edited by
submission deadline 20 Feb 2027 | 3 articles | Viewed by 4812 | Submission Open
Keywords: clinical neurophysiology; neuroengineering; robotics; non-invasive transcranial brain stimulation; spinal stimula-tion; regenerative rehabilitation; neuroimaging; brain–computer interface; brain-spinal interface; virtual reality; higher-level cognitive functions; vision rehabilitation
(This special issue belongs to the Section Clinical Rehabilitation)
Ocular Surface Disease: Epidemiology, Diagnosis and Management submission deadline 20 Feb 2027 | 3 articles | Viewed by 4508 | Submission Open
Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Advances in Hepatitis: Prevention, Treatment, and Global Health Impact submission deadline 20 Feb 2027 | 4 articles | Viewed by 4397 | Submission Open
Keywords: hepatitis B; hepatitis C; liver disease; direct-acting antivirals (DAAs); global health; public health policy; viral hepa-titis elimination; health disparities; cirrhosis; vaccination programs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in the Pharmacotherapy of Diabetes
edited by Jonathan Watanabe, and
submission deadline 20 Feb 2027 | 3 articles | Viewed by 4371 | Submission Open
Keywords: diabetes; microvascular complications; macrovascular complications; diabetes technology; pharmacoepidemiology; care delivery; novel therapies
(This special issue belongs to the Section Pharmacology)
Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice
edited by
submission deadline 20 Feb 2027 | 4 articles | Viewed by 4262 | Submission Open
Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse
(This special issue belongs to the Section Cardiology)
Stroke Care: From Acute Interventions to Long-Term Recovery submission deadline 20 Feb 2027 | 2 articles | Viewed by 3814 | Submission Open
Keywords: cerebrovascular diseases; acute ischemic stroke; intravenous thrombolysis; endovascular thrombectomy; intracerebral hemorrhage; etiology; cerebral amyloid angiopathy; stroke rehabilitation
(This special issue belongs to the Section Clinical Neurology)
Clinical Research on Minimally Invasive Spine Surgery
edited by Daniel Fahim
submission deadline 20 Feb 2027 | 7 articles | Viewed by 3526 | Submission Open
Keywords: minimally invasive spine surgery; spine tumors; spine trauma; spine fractures; lumbar stenosis; lumbar spondylolisthesis; lumbar disc herniation; lumbar radiculopathy; thoracic disc herniations; cervical radiculopathy
(This special issue belongs to the Section Orthopedics)
Clinical Management of Traumatic Brain Injury
edited by Adam James Wells and Peter Hutchinson
submission deadline 20 Feb 2027 | 4 articles | Viewed by 3405 | Submission Open
Keywords: traumatic brain injury; clinical management TBI; neurocritical care; neuromonitoring; trauma neurosurgery; artificial intelligence
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Patients Before and After Kidney Transplantation
edited by
submission deadline 20 Feb 2027 | 4 articles | Viewed by 3339 | Submission Open
Keywords: chronic kidney disease; kidney function; kidney replacement therapy; kidney transplantation; kidney graft survival; post-transplant complications
(This special issue belongs to the Section Nephrology & Urology)
Cardiotoxicity Within Cardio-Oncology: Clinical Advances from Prediction to Management submission deadline 20 Feb 2027 | 4 articles | Viewed by 3323 | Submission Open
Keywords: cardio-oncology; cardiotoxicity; cancer therapy–related cardiac dysfunction; heart failure in cancer patients; biomarkers; multimodality imaging; risk stratification; cardioprotection; cancer survivors' care; multidisciplinary approach
(This special issue belongs to the Section Cardiology)
Advanced Endoscopy and Imaging in Gastrointestinal Diseases submission deadline 20 Feb 2027 | 3 articles | Viewed by 3220 | Submission Open
Keywords: advanced endoscopy; gastrointestinal imaging; minimally invasive therapy; early diagnosis; image-guided intervention; surgical planning; patient outcomes; gastrointestinal diseases
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Anterior Cruciate Ligament Injury Treatment
edited by
submission deadline 20 Feb 2027 | 4 articles | Viewed by 3160 | Submission Open
Keywords: anterior cruciate ligament (ACL) injury; ACL reconstruction techniques; nonoperative ACL treatment; ACL graft; knee biomechanics; return-to-sport assessment; ACL rehabilitation; neuromuscular and proprioceptive training; athletic injuries; performance-enhancing substances; reinjury prevention; psychological readiness; ACL performance testing; osteoarthritis risk
(This special issue belongs to the Section Orthopedics)
Current and Emerging Treatment Options in Chronic Liver Diseases
edited by Chandana B. Herath and Michael Praktiknjo
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2962 | Submission Open
Keywords: liver disease; liver fibrosis; liver cirrhosis; portal hypertension; liver cancer; therapies; immunological therapies for liver cancer; diabetic liver; type 2 diabetes and obesity; spontaneous bacterial peritonitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Thoracic Surgery Today: Innovations, Challenges, and Future Perspectives
edited by Jeffrey B. Velotta and
submission deadline 20 Feb 2027 | 4 articles | Viewed by 2905 | Submission Open
Keywords: thoracic surgery; minimally invasive thoracic surgery; innovation; esophageal surgery; robotic-assisted thoracic surgery; lung cancer; advanced techniques; thoracic surgical oncology; mediastinal surgery; mesothelioma surgery
(This special issue belongs to the Section General Surgery)
New Technologies for Personalized Medicine in Head and Neck Surgery submission deadline 20 Feb 2027 | 4 articles | Viewed by 2739 | Submission Open
Keywords: personalized medicine; head and neck surgery; 3D printing; surgical navigation; artificial intelligence; computer-assisted surgery; regenerative medicine; precision oncology; craniofacial reconstruction; biomaterials; virtual surgical planning; genomics and proteomics; tissue engineering; functional rehabilitation
(This special issue belongs to the Section Otolaryngology)
Clinical Research Advances in Gynecologic Oncology
edited by
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2717 | Submission Open
Keywords: ovarian cancer; endometrial cancer; breast cancer; molecular biology; gynecological cancers
(This special issue belongs to the Section Oncology)
Clinical Advances and Future Challenges for Occupational Health
edited by and Vincenza Pellicani
submission deadline 20 Feb 2027 | 3 articles | Viewed by 2325 | Submission Open
Keywords: work-related disease; precision medicine; gender differences; aging workforce; preventive strategies
(This special issue belongs to the Section Epidemiology & Public Health)
Dental Care and Oral Health in Adolescents and Children
edited by
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2313 | Submission Open
Keywords: oral health; oral diseases; diagnosis; dental treatment; treatment methods; general health; pediatric dentistry; special care dentistry; immunodeficiency; pediatric dental surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Chronic Kidney Disease: From Diagnosis to Treatment
edited by Debra Hain
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2250 | Submission Open
Keywords: chronic kidney disease; type 2 diabetes; diabetic complications; hemodialysis; nephrology nursing; older adults; palliative care; therapy; hypertension
(This special issue belongs to the Section Nephrology & Urology)
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