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Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 137

Special Issue Editors


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Guest Editor
Department of Surgery, Brandenburg Medical School, University Hospital Brandenburg/Havel, 14770 Brandenburg, Germany
Interests: gastric cancer; upper GI (tract); gender medicine; acute abdominal pain; appendicitis; emergency surgery; colorectal surgery; surgical teaching
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Guest Editor
Department of General, Abdominal, Vascular and Transplant Surgery, Otto-von-Guericke University with University Hospital, 39120 Magdeburg, Germany
Interests: immune response of Helicobacter pylori infection as a model of GI infection; mucosal immunology/bacterially induced inflammation; TFF peptide within the stomach/gastric mucosa as well as the whole GI tract; research on clinical care; surgical quality assurance; acute pancreatitis; oncosurgery; cancer genetics; gastrointestinal stroma tumors and further rare tumor lesions/growth; coincidence of malignant tumor lesions/growth; surgical aspects of gender medicine; surgical teaching/research on surgical teaching; hospital, quality, and risk management; scientific publishing in human medicine; editorial assistance
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Special Issue Information

Dear Colleagues,

Gastric cancer has declined in recent years but remains the fifth most common cancer in Germany and the second most common worldwide. Over the past few decades, there have been some significant changes in the treatment and therapy. Gastric cancer, once considered difficult to treat with medication, can now be treated with chemotherapy.

This has already made its way into neoadjuvant, adjuvant, and palliative treatment regimens.

There have also been changes in the surgical treatment; metastatic stomach cancer is no longer considered fatal. This, of course, only applies to limited metastases, e.g., oligometastasis of the liver.

There have also been subdivisions into subgroups, for example, with regard to the course of the disease in different age groups. The targeted investigation of specific characteristics in women has so far played a minor role. Evidence of gender differences has been available for some time. Signet ring carcinoma is considered particularly malignant and can have severe and often fatal consequences, especially in young women.

We believe it is time for gender-specific treatment and therapy for women, not only for stomach cancer but for all malignant diseases.

We therefore encourage you to submit your scientific work on the above-mentioned topic.

Prof. Dr. Claus Schildberg
Prof. Dr. Frank Meyer
Guest Editors

Manuscript Submission Information

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Keywords

  • gastric cancer
  • other cancers
  • other treatment
  • gender differences
  • diversity
  • new challances

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Published Papers (1 paper)

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Research

13 pages, 524 KB  
Article
Single-Time Gastroscopy in High-Risk Patients: Screening Effectiveness for Gastric Precancerous Conditions in a Low-To Moderate-Incidence Population
by Krystian Ciechański, Erwin Ciechański, Krystyna Kłosowska-Kapica and Barbara Skrzydło-Radomańska
J. Clin. Med. 2025, 14(19), 6910; https://doi.org/10.3390/jcm14196910 - 29 Sep 2025
Abstract
Background: Gastric cancer (GC) is the fifth most common malignancy worldwide. Early detection of precancerous conditions—atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia—is vital for surveillance. Objectives: To assess the accuracy of single high-quality endoscopy (HQE) in detecting advanced GPCs and to identify [...] Read more.
Background: Gastric cancer (GC) is the fifth most common malignancy worldwide. Early detection of precancerous conditions—atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia—is vital for surveillance. Objectives: To assess the accuracy of single high-quality endoscopy (HQE) in detecting advanced GPCs and to identify risk factors for AG, IM, and dysplasia. Methods: A retrospective review of 442 gastroscopies (2017–2022) at a single center. Endoscopic findings were compared with histology, including OLGA/OLGIM staging, dysplasia, and Helicobacter pylori (H. pylori) status. Results: The study population comprised 319 women (72.17%) and 123 men (27.83%), with a mean age of 59 years (SD: 12.53). AG, as defined by OLGA and OLGIM staging, was identified in 90 patients (20.36%) and 50 patients (11.31%), respectively. A total of 44 cases of de novo gastric dysplasia were observed, while HP infection was confirmed in 37 individuals (8.37%). We observed similar low sensitivity for detection of advanced OLGA (32.5%), OLGIM (40%), and dysplasia (19.7%) with relatively high specificity (~89%). Advanced AG and IM peaked at ages 51–53. Risk factors for advanced OLGIM included male sex (OR 2.26; p < 0.001) and presence of dysplasia (OR 2.09; p = 0.02). Dysplasia was positively associated with AG (OR 2.03; p < 0.001) and IM (OR 2.21; p < 0.001) but inversely associated with a family history of GC (OR 0.44; p < 0.001). Conclusions: A single HQE can help exclude advanced GPCs, but due to low sensitivity, gastric mapping biopsies remain crucial. Males are at increased risk of extensive IM. Family history of GC was linked to lower OLGA/OLGIM stages. Full article
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