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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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State of the Art in Spinal Cord Injuries: Clinical Rehabilitation and Management

edited by

Valerio Pisani

submission deadline 20 Mar 2027 | 6 articles | Viewed by 4622 | Submission Open

Keywords: neurorehabilitation; assistive technologies; neuroplasticity; neuromodulation; spinal cord injury

(This special issue belongs to the Section Clinical Rehabilitation)

Diagnosis, Treatment and Prognosis of Head and Neck Cancer

edited by

Armando De Virgilio

and Elena Russo

submission deadline 20 Mar 2027 | 5 articles | Viewed by 4001 | Submission Open

Keywords: head and neck neoplasms; surgical procedures; minimally invasive surgical procedures; radiotherapy; immunotherapy; biomarkers; treatment outcome; early diagnosis; prognosis; quality of life

(This special issue belongs to the Section Oncology)

Advances in Pacemaker Implantation: Past, Present, and Future Challenges

edited by Rahul N. Doshi and

Ankur A. Karnik

submission deadline 20 Mar 2027 | 1 articles | Viewed by 3799 | Submission Open

Keywords: pacing; physiologic pacing; left bundle area pacing; leadless pacing; lead management

(This special issue belongs to the Section Cardiology)

Trauma Surgery: Strategies, Challenges and Vision of the Future

edited by

Shai Factor

and Yaniv S. Warschawski

submission deadline 20 Mar 2027 | 3 articles | Viewed by 3710 | Submission Open

Keywords: orthopaedic surgery; fractures; injuries; upper limb; trauma

(This special issue belongs to the Section Clinical Research Methods)

Clinical Updates in Fractures: Orthopedics, Trauma Surgery, and Rehabilitation

edited by

Rahul Vaidya

submission deadline 20 Mar 2027 | 4 articles | Viewed by 3401 | Submission Open

Keywords: orthopedic surgery; global orthopedic health; surgical techniques; outreach; inreach; artificial intelligence; robotics; outcome measures

(This special issue belongs to the Section Orthopedics)

Misconceptions and Myths in Dermatology: From Clinic to Clarity

edited by Simon M. Mueller and Oliver Brandt

submission deadline 20 Mar 2027 | 1 articles | Viewed by 3235 | Submission Open

Keywords: misconceptions; misunderstanding; myths; errors; mistakes; skin; dermatology

(This special issue belongs to the Section Dermatology)

Clinical Diagnosis and Treatment in Oncology: Radiotherapy and Imaging Analysis

edited by

Giuseppe Ferrera

Pierpaolo Alongi

and

Francesco Cuccia

submission deadline 20 Mar 2027 | 1 articles | Viewed by 3007 | Submission Open

Keywords: radiomics; metabolic imaging; radiotherapy; predictive factors; response models; PET-CT; artificial intelligence; biomarkers; machine-learning

(This special issue belongs to the Section Oncology)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 20 Mar 2027 | 2 articles | Viewed by 2916 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

Spine Surgery: Clinical Advances and Practice Updates

edited by

Junho Song

submission deadline 20 Mar 2027 | 3 articles | Viewed by 2797 | Submission Open

Keywords: spine surgery; minimally invasive spine surgery; endoscopic spine surgery; robotics; artificial intelligence; spinal deformity; scoliosis; spinal trauma

(This special issue belongs to the Section Orthopedics)

Clinical Perspectives on Extracorporeal Membrane Oxygenation (ECMO)

edited by

Alexander Hermann

submission deadline 20 Mar 2027 | 5 articles | Viewed by 2787 | Submission Open

Keywords: extracorporeal membrane oxygenation (ECMO); extracorporeal life support (ECLS); extracorporeal cardiopulmonary resuscitation (eCPR); extracorporeal gas exchange; extracorporeal circulation; acute respiratory distress syndrome (ARDS); cardiogenic shock (CS)

(This special issue belongs to the Section Intensive Care)

Clinical Challenges in Heart Failure Management: 2nd Edition

edited by Paolo Severino, Gaetano M. Ruocco and

Andrea D'Amato

submission deadline 20 Mar 2027 | 2 articles | Viewed by 2624 | Submission Open

Keywords: acute heart failure; chronic heart failure; inotropic support; left ventricular assist device; cardiac contractility modulation; guanylate cyclase stimulators; quality of life; telemedicine; palliative care

(This special issue belongs to the Section Cardiology)

Current Advances in Non-Trauma Emergency Critical and Resuscitation Medicine

edited by

Sebastian Bergrath

submission deadline 20 Mar 2027 | 1 articles | Viewed by 2582 | Submission Open

Keywords: resuscitation; non-trauma critically ill; emergency department; resuscitation room management; neuro-critical emergency care; emergency department critical care

(This special issue belongs to the Section Emergency Medicine)

Current Challenges in Adult Congenital Heart Diseases

edited by

Agata Bielecka-Dabrowa

submission deadline 20 Mar 2027 | 3 articles | Viewed by 2358 | Submission Open

Keywords: adult congenital heart disease; quality of life; pregnancy in congenital heart disease; heart failure; arrhythmia; septal defect; congenital valve stenosis; coarctation of the Aorta; Fontan circulation; Tetralogy of Fallot

(This special issue belongs to the Section Cardiology)

Perspectives in Bionic Reconstruction and Post-Amputation Management

edited by

Alexander Gardetto

and Jennifer Ernst

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1931 | Submission Open

Keywords: bionic reconstruction; advanced prosthetics; neurorehabilitation; sensory feedback; motor control

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Updates on Pediatric Neurological Disorders and Neurorehabilitation

edited by

Lidia Perenc

and

Justyna Podgórska-Bednarz

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1913 | Submission Open

Keywords: child neurological disorders; neurorehabilitation; neurogenetics; treatment; quality of life; rehabilitation teams; congenital brain disorders; trauma; movement disorders; cerebral palsy

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Advances in Lower Limb Trauma and Orthopedic Surgery: From Bench to Bedside

edited by

Se Won Lee

and

Jihyo Hwang

submission deadline 20 Mar 2027 | 3 articles | Viewed by 1901 | Submission Open

Keywords: lower limb trauma; fracture fixation; arthroplasty; biomechanics; orthopaedic surgery; clin-ical outcomes; minimally invasive techniques; rehabilitation

(This special issue belongs to the Section Orthopedics)

Minimally Invasive Spine Surgery: Evidence, Advances and Controversies

edited by

Miltiadis Georgiopoulos

, Constantine Constantoyannis,

Mark A. MacLean

and Oliver Lasry

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1740 | Submission Open

Keywords: spine surgery; minimally invasive; MIS; MISS; endoscopic; tubular; fusion; laminectomy; discectomy; decompression; percutaneous; robotic; robotic-assisted; navigation; augmented-reality

(This special issue belongs to the Section Clinical Neurology)

Novel Perspectives in Transcatheter Aortic Valve Implantation

edited by Nay Min Htun

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1676 | Submission Open

Keywords: TAVI; life-time management; TAVI-in-TAVI; bicuspid valve; pure aortic regurgitation; small annuli

(This special issue belongs to the Section Cardiology)

Gynecologic Cancers: Current Clinical Management and Multidisciplinary Treatment Strategies

edited by

Iason Psilopatis

and

Christos Damaskos

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1592 | Submission Open

Keywords: gynecologic; cancer; uterus; ovarian; endometrial; cervical

(This special issue belongs to the Section Obstetrics & Gynecology)

New Perspective of Oral and Maxillo-Facial Surgery: 2nd Edition

edited by

Valentino Vellone

Umberto Committeri

and Alessandra Lucchese

submission deadline 20 Mar 2027 | 3 articles | Viewed by 1558 | Submission Open

Keywords: maxillofacial surgery; esthetic surgery; orthognatic surgery; TMJ disorders; TMJ surgery; dental implant surgery; 3D imaging; printing applications; tissue engineering; personalized treatment planning; artificial intelligence; squamous cell carcinoma; skin tumors; plastic and reconstructive surgery; head and neck surgery; ENT surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cataract and Refractive Surgery, and Intraocular Lens (IOL) Implantation: Advancing Diagnosis and Management

edited by Olga Reitblat

submission deadline 20 Mar 2027 | 3 articles | Viewed by 1547 | Submission Open

Keywords: cataract surgery; premium intraocular lenses (IOLs); IOL power calculation; visual outcomes; refractive cataract surgery; multifocal IOL; extended depth of focus (EDOF) IOL; toric IOL; full range; vision IOL; biometry

(This special issue belongs to the Section Ophthalmology)

Orthodontics: Current Management and Future Options

edited by Arūnas Vasiliauskas and Aistė Kavaliauskienė

submission deadline 20 Mar 2027 | 3 articles | Viewed by 1509 | Submission Open

Keywords: digital orthodontics; clear aligner therapy; accelerated tooth movement; micro-implants; artificial intelligence; patient-centred outcomes; treatment efficiency

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Management of Diabetes-Related Cardiovascular Disease: Current Treatment and Future Options

edited by Antonio J. Amor and Tonet Serés-Noriega

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1506 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; cardiovascular disease; biomarkers; atherosclerosis; cardioprotective drugs; vascular ultrasound

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Outcomes in Lumbar Spinal Stenosis Treatment

edited by Rafał Staszkiewicz and

Beniamin Oskar Grabarek

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1461 | Submission Open

Keywords: lumbar spinal stenosis; clinical outcomes; decompression surgery; conservative management; molecular biomarkers; inflammation and fibrosis; neurotrophic factors; personalized medicine; siganling pathways; quality of life

(This special issue belongs to the Section Orthopedics)

Advances in Interventional Cardiology: From Access to Outcomes

edited by James Cotton and Benjamin Wrigley

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1368 | Submission Open

Keywords: interventional cardiology; acute coronary syndrome; chronic coronary syndrome; TAVI; TAVR; TEER; TMVR; T-TEER; TTVR; service redesign

(This special issue belongs to the Section Cardiology)

Novel Research in Cardiovascular Imaging

edited by Stanciu Silviu and

Lucia Agoston-Coldea

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1364 | Submission Open

Keywords: echocardiography; cardiac CT; CMR; nuclear medicine; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

Current Therapeutic Approaches to Addictive Disorders

edited by Linda Haddad

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1238 | Submission Open

Keywords: addiction treatment; dependence; withdrawal management; relapse prevention; recovery; rehabilitation and support

(This special issue belongs to the Section Mental Health)

Pulmonary Hypertension and Chronic Lung Disease: Diagnosis and Management

edited by

Josep Montserrat-Capdevila

and

Emmanuel E. Egom

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1105 | Submission Open

Keywords: pulmonary hypertension; chronic obstructive pulmonary disease (COPD); chronic lung disease; epidemiology; exacerbations; comorbidities; risk factors; diabetes; systemic inflammation; real-world data

(This special issue belongs to the Section Respiratory Medicine)

Diagnosis and Treatment of Pleura and Lung: Clinical Advances in Intensive Care

edited by

Alen Protić

and

Vlatka Sotosek

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1091 | Submission Open

Keywords: thoracic drainage; lung recruitment; lung ultrasound; pleural effusion; pneumothrax; B-line; lung atelectasis

(This special issue belongs to the Section Intensive Care)

Rebuilding the Knee: From Repair to Replacement and Recovery

edited by Young-Jin Seo

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1006 | Submission Open

Keywords: cartilage; meniscus; total knee arthroplasty; knee surgery; anterior cruciate ligament injuries; posterior cruciate ligament injuries; ligament reconstruction; patellofemoral disorders; osteotomy; sports medicine; rehabilitation; functional recovery

(This special issue belongs to the Section Orthopedics)

Updates on Reconstructive Urology

edited by

Fabio Campodonico

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1001 | Submission Open

Keywords: reconstructive urology; urethral stenosis; urethroplasty; urethral diverticulum; ureteral stenosis; male incontinence; urinary diversion; hypospadias; microsurgery; experimental microsurgery; bladder diverticulum; neobladder

(This special issue belongs to the Section Nephrology & Urology)

Digital Innovations in Obstetrics and Gynecology: Artificial Intelligence, Diagnostic Advances, Minimally Invasive Surgery, and Clinical Decision-Making

edited by

Iason Psilopatis

submission deadline 20 Mar 2027 | 2 articles | Viewed by 926 | Submission Open

Keywords: obstetrics; gynecology; artificial intelligence; machine learning; minimally invasive surgery; digital health

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

New Insights in Trauma and Emergency Surgery

edited by Kai Oliver Jensen and Valentin Neuhaus

submission deadline 20 Mar 2027 | 1 articles | Viewed by 908 | Submission Open

Keywords: trauma and emergency surgery; multiple trauma; orthopedic trauma; surgery; concepts in trauma

(This special issue belongs to the Section Emergency Medicine)

What We See Through Cardiac Imaging: Second Edition

edited by

Valeria Pergola

and

Francesca Mantovani

submission deadline 20 Mar 2027 | 1 articles | Viewed by 889 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; echocardiography; cardiac-computed tomography; cardiac magnetic resonance; prognosis; arrhythmias; heart failure

(This special issue belongs to the Section Cardiology)

Hemophilia: Current Trends and Future Directions: 2nd Edition

edited by

Jonathan C. Roberts

and

Michael B. Nichol

submission deadline 20 Mar 2027 | 1 articles | Viewed by 767 | Submission Open

Keywords: hemophilia; prophylaxis; gene therapy; burden of illness; quality of life; patient reported outcomes; hemarthrosis; women and hemophilia

(This special issue belongs to the Section Hematology)

Exploring Diagnostic and Therapeutic Advances in Neurodegenerative Disorders

edited by

Stefania Kalampokini

and

Effrosyni Koutsouraki

submission deadline 20 Mar 2027 | 1 articles | Viewed by 728 | Submission Open

Keywords: neurodegenerative disease; Parkinson’s disease; Alzheimer’s disease; Friedreich’s ataxia; Huntington’s disease; Lewy body dementia; dementia; immunosenescence; inflammaging

(This special issue belongs to the Section Clinical Neurology)

Colorectal Surgery: Advances in Modern Clinical Management

edited by

Algimantas A. Tamelis

submission deadline 20 Mar 2027 | 1 articles | Viewed by 715 | Submission Open

Keywords: colorectal cancer management; surgery; complications; organ preservation; screening; colonic diverticular disease; colonic diverticulitis; hemorrhoids

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Thyroid Cancer: Diagnosis, Surgical Treatment and Postoperative Radioactive Iodine Therapy: 2nd Edition

edited by Alfred A. Simental

submission deadline 20 Mar 2027 | 1 articles | Viewed by 709 | Submission Open

Keywords: thyroid nodule; thyroid ultrasound; radiofrequency ablation; molecular analysis; thyroid surgery

(This special issue belongs to the Section Oncology)

Pediatric Orthopedics: Diagnosis, Treatment, and Comprehensive Management

edited by Michał Latalski and

Erich Rutz

submission deadline 20 Mar 2027 | 2 articles | Viewed by 619 | Submission Open

Keywords: pediatric orthopedics; cerebral palsy; SMA; spinal deformities; developmental dysplasia of the hip; clubfoot; neuro-orthopedics; gait analysis; pediatric traumatology; skeletal dysplasia; biomechanics; congenital musculoskeletal anomalies

(This special issue belongs to the Section Orthopedics)

Atrial Fibrillation: Contemporary Evidence from Prevention to Catheter Ablation

edited by

Bogdan Enache

, Radu Gabriel Vătăşescu and

Dragos Cozma

submission deadline 20 Mar 2027 | 1 articles | Viewed by 600 | Submission Open

Keywords: atrial fibrillation; prevention; risk-factor modification; screening; rhythm control; catheter ablation; stroke prevention; outcomes

(This special issue belongs to the Section Cardiology)

New Insights into Gastrointestinal Surgery: Advances in Techniques and Treatment Approaches

edited by Gabriella Teresa Capolupo

submission deadline 20 Mar 2027 | Viewed by 517 | Submission Open

Keywords: gastroenterology; gastrointestinal surgery; colorectal surgery; robotic surgery; technologies; minimally invasive surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Challenges and Innovation in Trauma and Acute Care Surgery

edited by Michel Teuben

submission deadline 20 Mar 2027 | Viewed by 488 | Submission Open

Keywords: traumatology; trauma surgery; acute care surgery; femur; injury

(This special issue belongs to the Section Emergency Medicine)

Clinical Advances in Extracorporeal Membrane Oxygenation (ECMO)—Second Edition

edited by

Sung-Min Cho

and

Akram Zaaqoq

submission deadline 20 Mar 2027 | 1 articles | Viewed by 393 | Submission Open

Keywords: extracorporeal membrane oxygenation; ECMO; multi-organ failure; outcomes; V-A ECMO; ECPR; V-V ECMO; translational research; clinical research

(This special issue belongs to the Section Intensive Care)

Clinical Recent Advances in the Surgical Treatment of Heart Valve Disease

edited by

Beatrice Bacchi

and Aleksander Dokollari

submission deadline 20 Mar 2027 | Viewed by 387 | Submission Open

Keywords: heart valve surgery; prosthetic valves; intervention surgery; minimally invasive and robotic surgery; valve repair and replacement

(This special issue belongs to the Section Cardiology)

Clinical Updates on Anesthesia and Perioperative Medicine

edited by Béla Fülesdi and

Sorin J. Brull

submission deadline 20 Mar 2027 | Viewed by 386 | Submission Open

Keywords: anesthesia; perioperative complications; residual neuromuscular block; postoperative pulmonary complications; intensive care unit acquired weakness; intensive care medicine; airway management; patient safety

(This special issue belongs to the Section Anesthesiology)

Gastroparesis: Emerging Insights and Endoscopic Therapeutic Strategies

edited by Sabrina Testoni

submission deadline 20 Mar 2027 | Viewed by 361 | Submission Open

Keywords: gastroparesis; gastric dismotility; gastric emptying; gastric per-oral miotomy; pyloromyotomy; gastric electric stim-ulation; botulinum toxin

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Pediatric Hepatobiliary Surgery

edited by Ioannis A. Ziogas

submission deadline 20 Mar 2027 | Viewed by 360 | Submission Open

Keywords: pediatric hepatobiliary surgery; pediatric transplantation; pediatric surgery; liver transplantation; biliary atresia; choledochal cyst; liver cancer

(This special issue belongs to the Section Clinical Pediatrics)

Neuroimmunology in Neurological Disorders: Clinical Diagnosis and Treatment

edited by Charalampos Skarlis,

Maria Anagnostouli

and

Evangelia Liouta

submission deadline 20 Mar 2027 | Viewed by 357 | Submission Open

Keywords: neuroimmunology; neuroinflammation; neurodegenerative diseases; Parkinson’s disease; multiple sclerosis; CNS autoimmune disease; biomarkers; immunomodulatory therapy

(This special issue belongs to the Section Clinical Neurology)

New Clinical Insight: From Open Surgery to Minimally Invasive Foot and Ankle Surgery

edited by Enrique A. Testa and Daniel Poggio

submission deadline 20 Mar 2027 | Viewed by 357 | Submission Open

Keywords: minimally invasive surgery; foot surgery; ankle surgery; trauma surgery; orthopedic surgery; ankle arthroscopy

(This special issue belongs to the Section Orthopedics)

Colorectal Surgery: Current Concept and Emerging Trends

edited by