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Pulmonary Hypertension and Chronic Lung Disease: Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 654

Special Issue Editors


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Guest Editor
Family and Community Medicine Teaching Unit, Lleida Health Region, Catalan Health Institute (ICS), 25007 Lleida, Spain
Interests: COPD; cardiovascular risk; epidemiology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Institut du Savoir Montfort in Ottawa, Ottawa, ON, Canada
2. Montfort Hospital in Ottawa, Ottawa, ON, Canada
Interests: heart failure; pulmonary hypertension; cardio-metabolic disorders

Special Issue Information

Dear Colleagues,

Pulmonary hypertension (PH) is a frequent and underestimated complication among patients with chronic lung diseases, particularly those with chronic obstructive pulmonary disease (COPD). The interplay between pulmonary vascular remodeling, hypoxia, inflammation, and systemic comorbidities leads to significant morbidity and mortality. This Special Issue aims to gather original research, reviews, and clinical insights that advance the understanding of epidemiology, pathophysiology, diagnosis, and treatment of PH in chronic lung disease.
We are particularly interested in studies focusing on real-world data, population-based analyses, and epidemiological approaches to identify predictors of disease progression, exacerbations, and outcomes. Topics may include the interaction between cardiovascular and metabolic comorbidities (such as diabetes or obesity), biomarkers of systemic inflammation, new therapeutic strategies, and the role of multidisciplinary management in improving patient prognosis. Our goal is to promote translational research and bridge the gap between clinical practice and emerging scientific evidence.

Dr. Josep Montserrat-Capdevila
Dr. Emmanuel E. Egom
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pulmonary hypertension
  • chronic obstructive pulmonary disease (COPD)
  • chronic lung disease
  • epidemiology
  • exacerbations
  • comorbidities
  • risk factors
  • diabetes
  • systemic inflammation
  • real-world data

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Published Papers (1 paper)

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Research

10 pages, 232 KB  
Article
Determinants of All-Cause Mortality in Spirometry-Confirmed COPD in Primary Care: A Population-Based Multidimensional Cohort Study
by Josep Montserrat-Capdevila, Pilar Vaqué Castilla, Jennyfer Jiménez Díaz, Albert Romero Gracia, Araceli Fuentes, Eugeni Paredes, Joan Deniel-Rosanas, Daniel Martinez-Laguna, Sandra Moreno Garcia, Joaquim Sol and Pere Godoy
J. Clin. Med. 2026, 15(6), 2223; https://doi.org/10.3390/jcm15062223 - 14 Mar 2026
Viewed by 444
Abstract
Background/Objectives: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide and a systemic condition in which outcomes are influenced by respiratory impairment, multimorbidity, exacerbation burden, and functional status. This study aimed to identify multidimensional determinants of all-cause mortality in [...] Read more.
Background/Objectives: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide and a systemic condition in which outcomes are influenced by respiratory impairment, multimorbidity, exacerbation burden, and functional status. This study aimed to identify multidimensional determinants of all-cause mortality in a population-based cohort of primary care patients with spirometry-confirmed COPD. Methods: We conducted a retrospective population-based cohort study using electronic health records from primary care in the Lleida health region (Catalonia, Spain). Adult patients with spirometry-confirmed COPD (FEV1/FVC < 0.70) between 2019 and 2023 were included. Baseline demographic, clinical, spirometric, functional, and social variables were extracted. Exacerbations in the year prior to baseline were classified as 0, 1, or ≥2 events (and, where available, as moderate vs. severe) using a prespecified operational definition. The primary outcome was all-cause mortality during follow-up (censoring date: 31 December 2023). Time-to-event analyses were performed using Cox proportional hazards models. Results: A total of 2056 patients were included (median age 71 years; 78.4% male). During follow-up, 558 patients died (27.1%). Independent predictors of mortality included male sex, increasing age, current smoking, and prior exacerbations, whereas sufficient physical activity and better lung function (FEV1 % predicted) were protective. Conclusions: Mortality in spirometry-confirmed COPD managed in primary care is driven by a multidimensional vulnerability profile beyond lung function alone. Integrating respiratory, clinical, and functional determinants may improve risk stratification and management in chronic lung disease. Full article
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