Perspectives in Bionic Reconstruction and Post-Amputation Management

Dear Colleagues,

Advances in surgical techniques, postoperative recovery, and rehabilitation after amputation are now central to modern bionic reconstruction. Progress in Targeted Sensory Reinnervation, Targeted Muscle Reinnervation, Agonist–Antagonist Myoneural Interface, Osseointegration, and regenerative strategies such as Regenerative Peripheral Nerve Interfaces, together with next-generation prosthetic systems, is redefining functional restoration. Contemporary prostheses integrate high-resolution sensors, AI-assisted control, and optimized biomechanical design, enabling more natural motor execution and enhanced sensory feedback. Complementary neurorehabilitation protocols and embodiment-focused training further strengthen long-term outcomes.

In this Special Issue, we invite authors to contribute high-quality manuscripts that illuminate current advances and future directions in prosthetic innovation and amputation management.

Prof. Dr. Alexander Gardetto
Guest Editor

Dr. Jennifer Ernst
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.