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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Prevention, Diagnosis, and Rehabilitation of Sports Injuries
edited by Kevin Laudner
submission deadline 10 Dec 2025 | 3 articles | Viewed by 5706 | Submission Open
Keywords: orthopedics; prevention; rehabilitation; management; sports injuries
(This special issue belongs to the Section Sports Medicine)
Cardiac Arrhythmias: Current Status and Future Directions
edited by
submission deadline 10 Dec 2025 | 1 articles | Viewed by 4947 | Submission Open
Keywords: ventricular tachycardia; atrial fibrillation; catheter ablation; novel therapies; complex arrhythmias
(This special issue belongs to the Section Cardiology)
Kidney Transplantation and Rehabilitation: Current Updates and Perspectives
edited by Zoltán Sándor
submission deadline 10 Dec 2025 | 2 articles | Viewed by 4794 | Submission Open
Keywords: chronic kidney disease; kidney transplantation; transplant rehabilitation; transplant care; physical therapy; occupational therapy; intervention; recovery; quality of life; aftercare
(This special issue belongs to the Section Nephrology & Urology)
Latest Research on Male Infertility submission deadline 10 Dec 2025 | Viewed by 473 | Submission Open
Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Clinical Advances in Arthroscopic Shoulder Surgery
edited by Anup Ajit Shah, Michael J. O’Brien and Asheesh Bedi
submission deadline 10 Dec 2025 | Viewed by 430 | Submission Open
Keywords: rotator cuff; biologic tuberoplasty; lower trapezius tendon transfer; arthroscopic Latarjet; arthroscopic bone block; augmentation of the cuff
(This special issue belongs to the Section Orthopedics)
Innovative Endodontics
edited by
submission deadline 10 Dec 2025 | Viewed by 141 | Submission Open
Keywords: regenerative endodontics; bioceramics; guided endodontics; AI in endodontics; pericervical dentine; reduced taper; irrigation adjuvant; pulp regeneration
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Updates on Geriatric Oncology
edited by Cherif N. Boutros
submission deadline 12 Dec 2025 | Viewed by 144 | Submission Open
Keywords: geriatric oncology; cancer in elderly; geriatric cancer care; frailty; access to cancer care
(This special issue belongs to the Section Geriatric Medicine)
Physical Activity, Exercise and Health: Clinical Management and Research submission deadline 15 Dec 2025 | 7 articles | Viewed by 9699 | Submission Open
Keywords: physical activity; exercise; exercise physiology; exercise prescription; aging; women’ s health; chronic disease
(This special issue belongs to the Section Epidemiology & Public Health)
Recent Advances in the Management of Fractures
edited by Giulio Maccauro and
submission deadline 15 Dec 2025 | 6 articles | Viewed by 7772 | Submission Open
Keywords: trauma; fractures; prosthesis; megaprosthesis; modular prosthesis; plate; nail; combo; screw; rehabilitation; radiology
(This special issue belongs to the Section Orthopedics)
Coronary Heart Disease: Causes, Diagnosis and Management
edited by
submission deadline 15 Dec 2025 | 3 articles | Viewed by 7508 | Submission Open
Keywords: coronary heart disease; coronary revascularization; coronary artery disease; ischemic heart disease; atherosclerosis
(This special issue belongs to the Section Cardiology)
Aortic Pathologies: Aneurysm, Atherosclerosis and More
edited by Alexander Gombert and Panagiotis Doukas
submission deadline 15 Dec 2025 | 4 articles | Viewed by 7254 | Submission Open
Keywords: aorta; aortic aneurysm; thoracoabdominal aortic aneurysm; fenestrated endovascular aortic repair (FEVAR); branched endovascular aortic repair (BEVAR); spinal cord ischemia; coral reef aorta; surgery; endovascular aortic surgery
(This special issue belongs to the Section Cardiovascular Medicine)
Spine Surgery: Clinical Advances and Future Directions
edited by and Eun-Sang Kim
submission deadline 15 Dec 2025 | 4 articles | Viewed by 6483 | Submission Open
Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain
(This special issue belongs to the Section Clinical Neurology)
Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come
edited by Dirk Stengel and
submission deadline 15 Dec 2025 | 5 articles | Viewed by 6463 | Submission Open
Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries
(This special issue belongs to the Section Orthopedics)
Neural Application of Artificial Intelligence in Clinical Neuroscience
edited by Saurabh J. Singhal
submission deadline 15 Dec 2025 | 3 articles | Viewed by 4068 | Submission Open
Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction
(This special issue belongs to the Section Clinical Neurology)
Male Sexual and Reproductive Health: Clinical Aspects, Metabolic Profile, Environmental Factors and Lifestyle: 2nd Edition
edited by
submission deadline 15 Dec 2025 | 2 articles | Viewed by 3129 | Submission Open
Keywords: male sexual dysfunction; reproductive health; erectile dysfunction; premature ejaculation; infertility; epidemiology; causes; diagnosis; treatments; environmental factors; lifestyle
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Advances in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 15 Dec 2025 | 3 articles | Viewed by 2871 | Submission Open
Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine
(This special issue belongs to the Section Ophthalmology)
Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition
edited by Senthil Sambandam
submission deadline 15 Dec 2025 | 2 articles | Viewed by 2066 | Submission Open
Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement
(This special issue belongs to the Section Orthopedics)
Cataract and Refractive Surgery and Intraocular Lens Implantation: Clinical Advances and Perspectives
edited by Janusz Skrzypecki
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1889 | Submission Open
Keywords: cataract surgery; intraocular lens power calculation; intraocular lenses; EDoF IOL; multifocal IOL; monofocal IOL; laser refractive surgery
(This special issue belongs to the Section Ophthalmology)
Key Advances in the Treatment of the Critically Ill: 3rd Edition submission deadline 15 Dec 2025 | 2 articles | Viewed by 1695 | Submission Open
Keywords: respiration; artificial ventilation; prone positioning; respiratory distress syndrome; respiratory insufficiency; cardiac arrest; induced hypothermia; amiodarone; vasopressin; steroids; epinephrine; trauma; injuries; tranexamic acid; sepsis; antibiotics; extracorporeal membrane oxygenation; extracorporeal CPR; blood purification
(This special issue belongs to the Section Intensive Care)
Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition
edited by
submission deadline 15 Dec 2025 | 2 articles | Viewed by 1643 | Submission Open
Keywords: cardiac arrhythmias; cardiac implantable electronic device; catheter ablation; sudden cardiac death; lead extraction; atrial fibrillation; ventricular tachycardia; defibrillator therapy
(This special issue belongs to the Section Cardiology)
Clinical Advancements in Intraocular Lens Power Calculation Methods
edited by and Thomas Kohnen
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1440 | Submission Open
Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry
(This special issue belongs to the Section Ophthalmology)
Rheumatoid Arthritis: Challenges, Innovations and Outcomes
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1338 | Submission Open
Keywords: rheumatoid arthritis; pathogenesis; treatments; outcomes; autoimmunity
(This special issue belongs to the Section Immunology & Rheumatology)
Cancers of the Pelvic Organs: Contemporary Management and Actions for Improving Patients’ Quality of Life: 2nd Edition submission deadline 15 Dec 2025 | 1 articles | Viewed by 1225 | Submission Open
Keywords: gynecological cancers; e.g.; endometrial; cervical; ovarian; and vulvar cancer; urogenital tract cancers in men; e.g.; bladder; prostate; penis; and testicular cancer; gastrointestinal cancers; complications of oncological treatment; e.g.; pelvic floor disfunction: incontinence and POP; patients’ quality of life and possibilities of its improvement; oncofertility; physiotherapy; oncology treatment (modern surgical approach; including robotics; chemotherapy; radiotherapy; immunotherapy; targeted therapy); biological basis of pathogenesis and cancer progression; biological markers; anticancer agents; cancer prophylaxis and prevention— current trends and opportunities
(This special issue belongs to the Section Oncology)
Emergency Surgery: Clinical Updates and New Perspectives
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1204 | Submission Open
Keywords: emergency surgery; trauma surgery; acute abdomen; hernia emergencies; surgical decision making; perioperative care; damage control surgery; emergency management; critical care surgery; multidisciplinary approach
(This special issue belongs to the Section Emergency Medicine)
Latest Advances in Pediatric Surgery
edited by Francesco Macchini and Andrea Zanini
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1197 | Submission Open
Keywords: pediatric surgery; innovations; fluorescence-guided surgery; pediatric robotic surgery; minimally invasive surgery
(This special issue belongs to the Section General Surgery)
Clinical Advances in Cardio-Rheumatology submission deadline 15 Dec 2025 | 1 articles | Viewed by 992 | Submission Open
Keywords: cardio-rheumatology; autoimmune diseases; cardiac imaging; cardiovascular disease; autoimmune rheumatic diseases
(This special issue belongs to the Section Cardiology)
Clinical Prediction, Diagnosis, and Treatment of Ovarian Cancer and Other Gynecologic Tumors
edited by Eleni T. Timotheadou and Emmanouil Saloustros
submission deadline 15 Dec 2025 | 1 articles | Viewed by 908 | Submission Open
Keywords: ovarian; endometrial; cervical; chemotherapy; immunotherapy; primary debulking surgery; interval debulking; fertility-sparing surgery; PARP inhibitors; radiotherapy; HIPEC; sex cord tumors; dysgerminoma; leiomyosarcoma; liquid biopsies; circulating tumor cells; ctDNA
(This special issue belongs to the Section Obstetrics & Gynecology)
New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases: 2nd Edition submission deadline 15 Dec 2025 | 1 articles | Viewed by 766 | Submission Open
Keywords: therapeutic drug monitoring; inflammatory bowel diseases; immune mediated inflammatory diseases; pharmacokinetics; anti-TNF; vedolizumab; ustekinumab; risankizumab; point-of-care assays; model informed precision dosing
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies
edited by Claus Schildberg and Frank Meyer
submission deadline 15 Dec 2025 | 2 articles | Viewed by 670 | Submission Open
Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Pediatric Asthma
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 639 | Submission Open
Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life
(This special issue belongs to the Section Clinical Pediatrics)
Thoracic Surgery: Current Practice and Future Directions: 2nd Edition
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 484 | Submission Open
Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS
(This special issue belongs to the Section Respiratory Medicine)
Blood Cancer: Current Status and Future Challenges in Acute Myeloid Leukemia (AML)
edited by and Massimo Breccia
submission deadline 15 Dec 2025 | Viewed by 428 | Submission Open
Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders
(This special issue belongs to the Section Hematology)
Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment
edited by Massimiliano Mariani
submission deadline 15 Dec 2025 | 1 articles | Viewed by 320 | Submission Open
Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies
(This special issue belongs to the Section Cardiology)
Clinical Advances in Cancer Imaging submission deadline 15 Dec 2025 | Viewed by 157 | Submission Open
Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging
(This special issue belongs to the Section Oncology)
Novel Prognostic Risk Factors in Acute Coronary Syndrome submission deadline 15 Dec 2025 | Viewed by 117 | Submission Open
Keywords: acute coronary syndrome; risk stratification; biomarkers; cardiovascular imaging; inflammation; genetics; heart– kidney interaction; cardio-pulmonary complications; neurological dysfunction; precision medicine
(This special issue belongs to the Section Cardiology)
Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders
edited by Natalia Motas and Veronica Manolache
submission deadline 17 Dec 2025 | 1 articles | Viewed by 1086 | Submission Open
Keywords: lung cancer; minimally invasive thoracic surgery (MITS); video-assisted thoracoscopic surgery (VATS); robot-assisted thoracic surgery (RATS); interventional pneumology; bronchoscopy; endobronchial ultrasound (EBUS); artificial intelligence (AI); lung nodule
(This special issue belongs to the Section Respiratory Medicine)
Clinical and Surgical Insights on Lung Cancer Treatment
edited by and Marco Schiavon
submission deadline 18 Dec 2025 | 1 articles | Viewed by 1089 | Submission Open
Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; clinical trials; robotic surgery; diagnosis; multimodal treatment; outcomes; targeted therapy
(This special issue belongs to the Section Respiratory Medicine)
Recent Advances in Transcatheter Aortic Valve Replacement: Second Edition
edited by and Maciej Dąbrowski
submission deadline 18 Dec 2025 | 2 articles | Viewed by 903 | Submission Open
Keywords: aortic stenosis; transcatheter; bioprosthesis; TAVI; transcatheter aortic valve replacement
(This special issue belongs to the Section Cardiovascular Medicine)
Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation submission deadline 19 Dec 2025 | 3 articles | Viewed by 2010 | Submission Open
Keywords: retinal diseases; macular degeneration; maculopathies; diabetic retinopathy; retinal vascular occlusions; retinitis pigmentosa
(This special issue belongs to the Section Ophthalmology)
An Update on Retinal Diseases: From Diagnosis to Treatment
edited by , Masahiko Sugimoto and Kenji Yamashiro
submission deadline 20 Dec 2025 | 15 articles | Viewed by 26191 | Submission Open
Keywords: retinal diseases; diagnosis; treatment; etiology; original article; review paper
(This special issue belongs to the Section Ophthalmology)
Recent Advances in Therapy of Trauma and Surgical Critical Care
edited by Rita Galeiras
submission deadline 20 Dec 2025 | 7 articles | Viewed by 22955 | Submission Open
Keywords: trauma management; trauma care; burn; critical care; damage control surgery; traumatic spinal cord injury
(This special issue belongs to the Section Emergency Medicine)
Sepsis and Organ Dysfunction: New Insights into Diagnosis and Treatment
edited by
submission deadline 20 Dec 2025 | 10 articles | Viewed by 20364 | Submission Open
Keywords: intensive care; sepsis; septic shock; biomarkers; multiorgan dysfunction syndrome; ex-tracorporeal methods; mortality
(This special issue belongs to the Section Intensive Care)
Clinical Diagnosis and Management of Neonatal Diseases
edited by Ayala Gover and
submission deadline 20 Dec 2025 | 10 articles | Viewed by 15108 | Submission Open
Keywords: newborn; preterm; neonatal intensive care; low birth weight; point-of-care ultrasound; neonatal monitoring
(This special issue belongs to the Section Clinical Pediatrics)
Substance and Behavioral Addictions: Prevention and Diagnosis
edited by
submission deadline 20 Dec 2025 | 7 articles | Viewed by 14700 | Submission Open
Keywords: substance addiction; behavioural addiction; clinical perspectives; prevention strategies; diagnostic protocols; differential diagnosis; psychopathology of addiction; psychopathology as a diagnostic tool; craving behavioural covariates
(This special issue belongs to the Section Mental Health)
Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition) submission deadline 20 Dec 2025 | 5 articles | Viewed by 11444 | Submission Open
Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Thoracic Surgery: Current Challenges and Future Perspectives
edited by and José Luis Campo-Cañaveral de la Cruz
submission deadline 20 Dec 2025 | 6 articles | Viewed by 11197 | Submission Open
Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Trauma and Acute Care Surgery Research: Innovations, Challenges, and Future Directions
edited by Frederick Rogers
submission deadline 20 Dec 2025 | 7 articles | Viewed by 11051 | Submission Open
Keywords: trauma care; best practices; clinical care; trauma system development; optimal trauma care
(This special issue belongs to the Section Intensive Care)
State-of-the-Art Innovations in Oral and Maxillofacial Surgery
edited by Marcin Kozakiewicz and Katarzyna Bogusiak
submission deadline 20 Dec 2025 | 8 articles | Viewed by 10819 | Submission Open
Keywords: oral surgery; maxillofacial surgery; traumatology; orthognatic surgery; infections; oncology; diagnostics; treatment; implantology; augmentation; imaging; computer-assisted techniques
(This special issue belongs to the Section Otolaryngology)
Advances in Trauma Care and Emergency Medicine submission deadline 20 Dec 2025 | 2 articles | Viewed by 9833 | Submission Open
Keywords: trauma; trauma care; emergency medicine; pre-hospital; emergency room; intensive care unit
(This special issue belongs to the Section Emergency Medicine)
Advances in Leveraging Big Data for Improving Patient Outcomes in Gastrointestinal and Hepatopancreatobiliary Diseases
edited by Saurabh Chawla
submission deadline 20 Dec 2025 | 4 articles | Viewed by 9573 | Submission Open
Keywords: big data; machine learning; artificial intelligence; gastroenterology; research; hepatopancreatobiliary
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
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