Current Evidence and Future Directions in Clostridioides difficile Infection Epidemiology, Diagnosis and Treatment
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Infectious Diseases".
Deadline for manuscript submissions: 28 January 2026 | Viewed by 14
Special Issue Editors
Interests: severe infections; infective endocarditis; emerging infections; infection control; Clostridioides difficile infection; antimicrobial resistance; antimicrobial treatment
Special Issues, Collections and Topics in MDPI journals
Interests: immune response; immunodeficiency disorders; host–pathogen interaction; host and microbiota interaction; Clostridioides difficile infection; antimicrobial resistance; antimicrobial treatment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Managing Clostridioides difficile infection (CDI) remains challenging due to several major issues. CDI is often underdiagnosed, either because of suboptimal laboratory diagnostic methods or a lack of clinical suspicion. The burden of CDI and CDI underdiagnosis varies between countries and hospitals, and the reasons for these differences need to be clarified. Community-acquired CDI is increasingly mentioned but poorly studied in practice. Furthermore, diagnostic and treatment guidelines are not properly adhered to regarding community-acquired CDI, resulting in suboptimal care and outcomes.
Another significant problem is the high recurrence rate of CDI with current treatments. This alarming recurrence rate highlights the need for new therapeutic approaches.
Furthermore, in order to reduce the spread of CDI, additional effort is needed. A comprehensive understanding of the role of asymptomatic carriers, foodborne and environmental transmission, and the transmission routes within humans, animals, and the environment is imperative, though this is challenging to achieve.
This Special Issue aims to deliver a compendium of the latest studies focused on any aspects of CDI.
Prof. Dr. Nicola Petrosillo
Dr. Guido Granata
Guest Editors
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Keywords
- Clostridioides difficile infection
- infection control
- contact isolation
- community-acquired CDI
- CDI recurrence
- recurrence prevention
- rCDI
- host and microbiota interaction
- antimicrobial treat-ment
- microbiota transplant
- underdiagnosis
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