New Insights into Peritoneal Dialysis and Hemodialysis: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 689

Special Issue Editor


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Guest Editor
Department of Nephrol Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy
Interests: dialysis; uremia; cardiorenal syndrome; organ crosstalk; kidney; biomarkers; chronic kidney disease; inflammation
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Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “New Insights into Peritoneal Dialysis and Hemodialysis: 2nd Edition”. In the first volume, we published 11 papers. For more details, please visit https://www.mdpi.com/journal/jcm/special_issues/463Z42Y7A5.

The incidence of end-stage renal disease is increasing year by year, and it is one of the most commonly fatal diseases in patients. Kidney replacement therapy (KRT) has made significant progress in recent decades, with about 70% of people receiving KRT undergoing dialysis, of whom about 10% undergo peritoneal dialysis and 90% undergo hemodialysis.

Nephrologists will face significant challenges in the future as the number of patients requiring KRT increases. In addition, some important pathophysiological features of patients, including accelerated systemic atherosclerosis, vascular calcification, inflammation, frailty, cognitive impairment, etc., have recently been revealed. The daily lives of dialysis patients are also restricted by fatigue, depression, and comorbidities. These disease states have complex effects on adverse events and prognosis in hemodialysis patients.

This Special Issue of the Journal of Clinical Medicine will explore the current state of dialysis, including hemodialysis and peritoneal dialysis. Future challenges and current research will be noted, including, but not limited to, the clinical application of hemodialysis and peritoneal dialysis, dialysis preparation, vascular access function, complications, dialysis membranes and techniques, unfavorable adverse effects, and other topics related to diagnosis, treatment, and management in patients. We welcome you to submit your latest original articles or reviews to provide clinicians with the latest insights concerning this field.

Dr. Grazia Maria Virzì
Guest Editor

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Keywords

  • hemodialysis
  • peritoneal dialysis
  • end-stage renal disease
  • kidney replacement therapy (KRT)
  • pathophysiology
  • di-alysis membranes
  • dialysis preparation
  • dialysis modality
  • cardiovascular events
  • vascular access
  • PD-related perito-nitis
  • unfavorable adverse effects
  • complications
  • challenges
  • inflammation

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Published Papers (1 paper)

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Research

12 pages, 543 KiB  
Article
Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Haemodiafiltration
by Matteo Marcello, Marco Simonini, Anna Lorenzin, Valentina Corradi, Grazia Maria Virzì, Carlotta Caprara, Alessandra Brendolan, Claudia Benedetti, Paolo Lentini, Monica Zanella and Claudio Ronco
J. Clin. Med. 2025, 14(6), 1798; https://doi.org/10.3390/jcm14061798 - 7 Mar 2025
Viewed by 502
Abstract
Background: Removal of large uraemic toxins is still a challenge. Haemodiafiltration (HDF) has produced some results, although large convective volume, optimal vascular access to increase the blood flow rate and strict water quality management are required. Medium cut-off, high-retention-onset membranes have been recently [...] Read more.
Background: Removal of large uraemic toxins is still a challenge. Haemodiafiltration (HDF) has produced some results, although large convective volume, optimal vascular access to increase the blood flow rate and strict water quality management are required. Medium cut-off, high-retention-onset membranes have been recently developed, introducing the concept therapy called expanded haemodialysis (HDx). Furthermore, vitamin E-coated membrane has potential beneficial effects on inflammation and oxidative stress. Methods: A prospective longitudinal multicentre study was conducted for 3 months among 24 chronic haemodialysis patients. Patients were randomly assigned into either HDF with high-flux membrane or HDx with Theranova or ViE-X membrane. The primary goal was to assess albumin loss among the three types of dialyzers. Secondary goals included assessment of depurative efficacy for uraemic toxins and clinical outcomes. Results: Mean albumin loss was significantly higher in patients undergoing HDx with Theranova membrane, without any difference in serum albumin concentration among the three groups. Instantaneous clearance of small and middle molecules was significantly higher in patients undergoing HDF, but we did not find differences in removal ratio and Kt/V. Reduction in the erythropoietin resistance index was observed in patients treated with ViE-X membrane due to their lower dialysis vintage. Conclusions: The higher albumin loss during HDx has no effects on pre-dialysis serum albumin. HDx with Theranova in the presence of lower session length, lower Qb, lower convective dose, and lower instantaneous clearance reached the same dialysis efficacy compared to HDF. Full article
(This article belongs to the Special Issue New Insights into Peritoneal Dialysis and Hemodialysis: 2nd Edition)
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