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Diagnosis and Treatment for Bone Tumor
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Diagnosis and Treatment for Bone Tumor

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 938

Special Issue Editors

Dr. Antonio Ziranu

E-Mail Website
Guest Editor
1. Orthopedics and Trauma Surgery, Università Cattolica del Sacro Cuore, Rome, Italy
2. Ospedale Isola Tiberina-Gemelli Isola, Rome, Italy
Interests: bone tumor; oncology; osteosarcoma; chondrosarcoma; megaprosthesis; bone resection; chemotherapy; radiotherapy
Dr. Luigi Cianni

E-Mail Website
Guest Editor
Department of Orthopaedics and Traumatology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: bone tumor; oncology; osteosarcoma; chondrosarcoma; megaprosthesis; bone resection; chemotherapy; radiotherapy

Special Issue Information

Dear Colleagues,

Bone tumors pose an arduous challenge for modern medicine due to their complex nature, diverse histological types, and often elusive early symptoms. Many advances have been made in the field of bone cancer diagnosis and treatment.

This is an evolving topic with considerable future prospects.

In this Special Issue, our goal is to analyze the problem starting from the diagnosis to arrive at surgical treatments and radiotherapy and chemotherapy.

It is important to identify and classify the bone tumor before surgery and intraoperatively: bone tumor diagnosis is achieved by combining numerous imaging techniques such as X-rays, MRI, and CT scans to biopsy to differentiate various tumor types.

Surgical treatment of bone cancer, which in many cases is combined with chemotherapy and/or radiotherapy treatment, is a challenge for the orthopedist as it depends on multiple factors such as tumor site, bone tissue involvement, or the patient's life expectancy. Recently, new perspectives in bone tumor management are emerging through the development of targeted therapies, immunotherapy and genetic editing techniques.

We invite doctors and researchers to contribute their work and research to this Special Issue. We hope through this Special Issue to collaborate to achieve ever-innovative methods of bone cancer diagnosis and treatment.

Dr. Antonio Ziranu
Dr. Luigi Cianni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone tumor
  • oncology
  • osteosarcoma
  • chondrosarcoma
  • megaprosthesis
  • bone resection
  • chemotherapy
  • radiotherapy
  • sarcoma
  • custom-made

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Published Papers (2 papers)

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9 pages, 1626 KiB  
Article
Preliminary Results of Surgical Treatment for Enchondroma Using a Novel Bioactive and Osseoconductive HAP/β–Glucan Bone Substitute FlexiOss®—Case Series
by Daniel Kotrych, Dawid Ciechanowicz, Filip Bielewicz, Andrzej Baryluk, Sebastian Podsiadło and Paweł Ziętek
J. Clin. Med. 2025, 14(11), 3738; https://doi.org/10.3390/jcm14113738 - 27 May 2025
Viewed by 435
Abstract
Background/Objectives: In the surgical treatment of benign bone tumors, bone substitutes are widely used. However, each of them has its advantages and disadvantages. We decided to study the novel bioactive and osseoconductive HAP/β–glucan bone substitute. Methods: We qualified eight patients with [...] Read more.
Background/Objectives: In the surgical treatment of benign bone tumors, bone substitutes are widely used. However, each of them has its advantages and disadvantages. We decided to study the novel bioactive and osseoconductive HAP/β–glucan bone substitute. Methods: We qualified eight patients with enchondroma of the lower limbs for this study, who underwent marginal resection of the lesion with the use of a bone substitute—FlexiOss®. During the 12-month follow-up, a series of X-rays and bone scintigraphy were performed. Bone remodeling was assessed using the modified Neer scale (MNS), while functional results were assessed using the MSTS scale. Results: Very good functional results were noted in all patients—MSTS = 27–30. In the MNS, Score I was recorded in six cases, and Score II was recorded in two cases. Among the complications in the two patients, a clear serous discharge from the wound was observed. Conclusions: The use of the new HAP/β–glucan composite in the treatment of enchondroma initially shows good treatment results. Full article
(This article belongs to the Special Issue Diagnosis and Treatment for Bone Tumor)
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19 pages, 2467 KiB  
Systematic Review
Reconstruction of the Extensor Apparatus After Total Patellectomy in Orthopedic Oncology: A Systematic Literature Review
by Edoardo Ipponi, Fabrizia Gentili, Fabio Cosseddu, Antonio D’Arienzo, Paolo Domenico Parchi and Lorenzo Andreani
J. Clin. Med. 2025, 14(14), 4818; https://doi.org/10.3390/jcm14144818 - 8 Jul 2025
Viewed by 290
Abstract
Background: Patellar resection is recommended in cases of massive cortical bone disruption or malignancies. Modern literature lacks a consensus surgical reconstruction after total patellectomy. Our study reviews the surgical techniques described in the literature and summarizes the reported functional outcomes and complication [...] Read more.
Background: Patellar resection is recommended in cases of massive cortical bone disruption or malignancies. Modern literature lacks a consensus surgical reconstruction after total patellectomy. Our study reviews the surgical techniques described in the literature and summarizes the reported functional outcomes and complication rates. Materials: We systematically reviewed the existing literature, searching the PubMed, Embase, and Scopus databases for articles published between 1950 and 2024. We recorded age, diagnosis, tumor size, Lodwick classification, soft tissue involvement, and pre-operative fractures for each case or case series. We also recorded the reconstructive approaches. Complications, local recurrences, MSTS scores, and knee range of motion (ROM) were considered when reported. Results: Twenty-eight articles met our inclusion criteria. Among these, 4 were case series and 24 were case reports. A total of 47 cases treated with total patellectomy were reviewed. Reconstruction was performed with direct suture in 8 cases, while 17 had local augments, including allograft (10 cases), muscle flaps or transportations (4), autologous bone (1), or a composite (2). Reconstruction was not mentioned in 22 cases. ROM was reported for 17 cases, and the MSTS score was reported for 9 cases. Conclusions: In cases of relatively small tissue defects, a direct suture of the extensor apparatus can allow adequate functional recovery. In cases of larger gaps, surgeons should use muscle flaps, transfers, or soft tissue augments. Massive bone and tendon allografts should mainly be considered in cases where the neoplasm was not confined to the patella but extensively involved the patellar ligament or the quadriceps tendon. Full article
(This article belongs to the Special Issue Diagnosis and Treatment for Bone Tumor)
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