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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Effect of Long-Term Insomnia on Mental Health—2nd Edition

edited by

Aleksandra Rogowska

submission deadline 20 Jan 2027 | 2 articles | Viewed by 13853 | Submission Open

Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress

(This special issue belongs to the Section Mental Health)

Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome

edited by

Razvan Ionut Ghinea

Ioana-Sofia Pop-Ciutrilă

and

Luminita-Maria Nica

submission deadline 20 Jan 2027 | 4 articles | Viewed by 11978 | Submission Open

Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Management and Long-Term Prognosis in Intensive Care

edited by

Wioletta Mędrzycka-Dąbrowska

and

Sandra Lange

submission deadline 20 Jan 2027 | 9 articles | Viewed by 11626 | Submission Open

Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation

(This special issue belongs to the Section Intensive Care)

Glaucoma Surgery: Current Challenges and Future Perspectives

edited by

Tina Tzee Ling Wong

and

Esther M. Hoffmann

submission deadline 20 Jan 2027 | 8 articles | Viewed by 9580 | Submission Open

Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics

(This special issue belongs to the Section Ophthalmology)

Acute Medical Threats: Evidence-Driven Strategies in Emergency Medicine

edited by

Alexandra Arvanitaki

submission deadline 20 Jan 2027 | 6 articles | Viewed by 8935 | Submission Open

Keywords: emergency medicine protocols; acute medical care; trauma management; resuscitation; critical care; infectious disease preparedness

(This special issue belongs to the Section Emergency Medicine)

Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition

edited by

Teresa Paolucci

and

Massimiliano Mangone

submission deadline 20 Jan 2027 | 4 articles | Viewed by 8634 | Submission Open

Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses

(This special issue belongs to the Section Orthopedics)

Heart Failure: Challenges and Future Options

edited by Pedro Caravaca-Pérez and Marta Farrero-Torres

submission deadline 20 Jan 2027 | 7 articles | Viewed by 7974 | Submission Open

Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types

edited by Andrea Paradisi

submission deadline 20 Jan 2027 | 4 articles | Viewed by 7713 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)

(This special issue belongs to the Section Dermatology)

Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments

edited by

Niccola Funel

, Paolo Domenico Parchi and Andrea del Chiaro

submission deadline 20 Jan 2027 | 5 articles | Viewed by 7678 | Submission Open

Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis, osteoarthritis, musculoskeletal disorder, pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches

(This special issue belongs to the Section Orthopedics)

Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes

edited by Giovanni Colombo and

Matteo Di Bari

submission deadline 20 Jan 2027 | 5 articles | Viewed by 6503 | Submission Open

Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life

(This special issue belongs to the Section Otolaryngology)

Clinical Updates in Transfusion Medicine and Patient Blood Management

edited by

Carlos Jerico

and

José Antonio García-Erce

submission deadline 20 Jan 2027 | 3 articles | Viewed by 6072 | Submission Open

Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine

(This special issue belongs to the Section Hematology)

Hospital-Acquired Infections: Insights, Prevention, and Control Strategies

edited by

Andrea Fabbri

submission deadline 20 Jan 2027 | 4 articles | Viewed by 5333 | Submission Open

Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department

(This special issue belongs to the Section Epidemiology & Public Health)

Artificial Intelligence and Machine Learning in Clinical Practice

edited by Theodosis Kalamatianos and

Ioannis Kakkos

submission deadline 20 Jan 2027 | 6 articles | Viewed by 5321 | Submission Open

Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis

(This special issue belongs to the Section General Surgery)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jan 2027 | 4 articles | Viewed by 5274 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

edited by Ivan Krečak, Marko Skelin and Zinaida Perić

submission deadline 20 Jan 2027 | 4 articles | Viewed by 4409 | Submission Open

Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis

(This special issue belongs to the Section Hematology)

Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective

edited by

Ki-Hyuk Lee

and

Koji Koyama

submission deadline 20 Jan 2027 | 3 articles | Viewed by 4137 | Submission Open

Keywords: artificial intelligence; machine learning and deep learning; large language models (LLMs); explainable AI; exercise and physical activity; rehabilitation and sports medicine; clinical applications; chronic disease and preventive health; digital health and big data analytics

(This special issue belongs to the Section Sports Medicine)

Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition

edited by

Pablo Demelo-Rodríguez

submission deadline 20 Jan 2027 | 3 articles | Viewed by 3977 | Submission Open

Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis

(This special issue belongs to the Section Hematology)

Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications

edited by Dilhana S. Badurdeen

submission deadline 20 Jan 2027 | 4 articles | Viewed by 3866 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; Roux-en-Y Gastric Bypass (RYGB); sleeve gastrectomy; revisional bariatric surgery; complications; outcomes; weight loss maintenance; metabolic syndrome; type 2 diabetes remission; nutritional deficiencies; gastrointestinal adaptation; quality of life; long-term follow-up

(This special issue belongs to the Section General Surgery)

Bronchoscopy and Interventional Pulmonology

edited by Bryan S. Benn and

Jonathan Kurman

submission deadline 20 Jan 2027 | 4 articles | Viewed by 3724 | Submission Open

Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction

(This special issue belongs to the Section Respiratory Medicine)

Spine Surgery: Current Challenges and Opportunities

edited by Kambiz Sarahrudi

submission deadline 20 Jan 2027 | 4 articles | Viewed by 3693 | Submission Open

Keywords: vertebral fracture; spine trauma; spinal cord injury; adjacent segment degeneration; infection; spondylodiscitis; verte-bral metastasis; osteoporotic fracture; fracture of sacrum; disk degeneration; degenerative spine surgery; minimally invasive spine surgery

(This special issue belongs to the Section Orthopedics)

Cardiac Imaging in Cardiovascular Disorders

edited by Leif-Christopher Engel

submission deadline 20 Jan 2027 | 3 articles | Viewed by 3545 | Submission Open

Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging

(This special issue belongs to the Section Cardiology)

Clinical Insights in Pediatric Dentistry

edited by

Giulia Orilisi

submission deadline 20 Jan 2027 | 2 articles | Viewed by 3498 | Submission Open

Keywords: pediatric dentistry; caries management; dental trauma; preventive dentistry; behavior management; interdisciplinary care; clinical innovations

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Advances in Congenital Heart Disease

edited by

Efrén Martínez-Quintana

submission deadline 20 Jan 2027 | 3 articles | Viewed by 3163 | Submission Open

Keywords: congenital heart disease; pediatric cardiology; adult congenital heart disease; cardiac surgery; interventional cardiology; long-term outcomes; cardiac imaging

(This special issue belongs to the Section Cardiology)

Interstitial Lung Diseases: New Treatments Based on Treatable Traits

edited by Francesco Amati

submission deadline 20 Jan 2027 | 1 articles | Viewed by 2938 | Submission Open

Keywords: interstitial lung diseases; progressive pulmonary fibrosis; phenotypes; endotypes; treatment; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Osteoporosis: A Renascent Impact of Vertebral Fractures in the Diagnosis and Management

edited by Csaba Horvath

submission deadline 20 Jan 2027 | 3 articles | Viewed by 2915 | Submission Open

Keywords: osteoporosis; vertebral fractures; imminent fracture risk; FRAX; bone densitometry; vertebral fracture assessment

(This special issue belongs to the Section Orthopedics)

Clinical Advances in the Management of Abdominal and Thoracoabdominal Aortic Aneurysms

edited by

Daniela Mazzaccaro

submission deadline 20 Jan 2027 | 4 articles | Viewed by 2850 | Submission Open

Keywords: abdominal aneurysm; thoraco-abdominal; computed-tomography angiography; branched endograft; branched endovascular aortic repair; fenestrated endograft; open surgery; 3-D printing

(This special issue belongs to the Section Vascular Medicine)

Acute and Chronic Heart Failure: Clinical Updates and Perspectives—2nd Edition

edited by Luigi Cappannoli and Cristina Aurigemma

submission deadline 20 Jan 2027 | 3 articles | Viewed by 2629 | Submission Open

Keywords: acute heart failure; chronic heart failure; devices; drug therapy; percutaneous ventricular assist devices; cardiogenic shock; arrhythmias; ischemic heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Ocular Surgeries: Innovations in Cataract, Retinal, and Beyond

edited by

Seung Pil Bang

and Yu Cheol Kim

submission deadline 20 Jan 2027 | 4 articles | Viewed by 2382 | Submission Open

Keywords: cataract surgery; retinal surgery; intraocular lenses; femtosecond laser; minimally invasive vitrectomy; ocular imaging; surgical innovation; ocular trauma; corneal transplantation; glaucoma surgery

(This special issue belongs to the Section Ophthalmology)

The Treatment of BPO with Minimal Invasive Approach

edited by

Lukas Lusuardi

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2363 | Submission Open

Keywords: benign prostatic obstruction (BPO); prostatectomy; non-muscle invasive bladder cancer; muscle invasive bladder cancer; robotic surgery

(This special issue belongs to the Section Nephrology & Urology)

Clinical Updates of Physical Therapy in Rehabilitation

edited by

Sofia Xergia

submission deadline 20 Jan 2027 | 1 articles | Viewed by 2305 | Submission Open

Keywords: neurological rehabilitation; musculoskeletal rehabilitation; special populations; new technology in physical therapy

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Male Infertility: Diagnosis, Management and ART Integration

edited by Despoina Mavrogianni and Sofoklis Stavros

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2284 | Submission Open

Keywords: male infertility; assisted reproductive technologies (ART); intracytoplasmic sperm injection (ICSI); genetic testing; hormonal profiling; seminal biomarkers; sperm retrieval techniques; sperm selection; stem cell therapy; gene editing; reproductive endo-crinology; early pregnancy; implantation failure; recurrent miscarriage

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Progress in Oral and Maxillofacial Surgery

edited by Luis M. Junquera and Giuseppe Consorti

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2265 | Submission Open

Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Bladder Cancer: Diagnosis, Treatment and Future Opportunities

edited by

Jørgen Bjerggaard Jensen

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2237 | Submission Open

Keywords: urology; bladder cancer; urothelial cancer; non-muscle invasive bladder cancer; muscle invasive bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Hypertrophic Cardiomyopathy: New Insights into Complications and Treatment

edited by Ilaria Dentamaro and Ciro Santoro

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2005 | Submission Open

Keywords: hypertrophic cardiomyopathy; complications; risk stratification; multimodality imaging; myosin inhibitors; precision medicine

(This special issue belongs to the Section Cardiology)

Clinical Updates on Perioperative Pain Management: 3rd Edition

edited by

Felice Eugenio Agro

Giuseppe Pascarella

and

Fabio Costa

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1854 | Submission Open

Keywords: anesthesia and intensive care; pain management; spinal anesthesia; postoperative pain; breast surgery; fascial plane blocks; abdominal surgery; cardiac surgery; thoracotomy; knee surgery; orthopedic surgery; hip surgery; ultrasound

(This special issue belongs to the Section Anesthesiology)

Coronary Artery Bypass Grafting: Contemporary Clinical Research Update

edited by

Arian Arjomandi Rad

submission deadline 20 Jan 2027 | 3 articles | Viewed by 1799 | Submission Open

Keywords: coronary artery bypass grafting; arterial grafts; graft patency; hybrid coronary revascularization; perioperative management; outcomes research; risk stratification; frailty; minimally invasive/robotic CABG; antithrombotic therapy

(This special issue belongs to the Section Cardiology)

Advances in Perinatal Mental Health: Prevention, Screening, Treatment, and Support Across Pregnancy and Postpartum

edited by

Rena Bina

submission deadline 20 Jan 2027 | 3 articles | Viewed by 1372 | Submission Open

Keywords: perinatal mental health; prevention; screening; access to care; eHealth; treatment; environmental factors; cross-cultural; systems of care; innovative methodologies

(This special issue belongs to the Section Mental Health)

Aortic Valve Replacement: Current Trends, Future Perspectives, and Emerging Technologies

edited by

Jorge Nuche

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1300 | Submission Open

Keywords: aortic valve; heart valve prosthesis; transcatheter aortic valve replacement; surgical aortic valve replacement; aortic valve insufficiency; minimally invasive surgical procedures; treatment outcome; vulnerable populations

(This special issue belongs to the Section Cardiology)

New Insights into Hepato-Biliary Diseases: Translating Science into Practice

edited by

Elisa Ceccherini

and

Antonella Cecchettini

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1249 | Submission Open

Keywords: hepato-biliary diseases; biomarkers; drug discovery; liver organoids and microfluidics; pathogenesis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Update on Aortic Valve Disease Treatments

edited by

Giovanni Concistre

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1188 | Submission Open

Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation

(This special issue belongs to the Section Cardiology)

Clinical Trends and Prospects in Urology Surgery: 2nd Edition

edited by

Lazaros Tzelves

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1172 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence

(This special issue belongs to the Section Nephrology & Urology)

Contemporary Management of Acute and Chronic Liver Disease: Advances in Diagnosis and Therapy

edited by Manisha Verma

submission deadline 20 Jan 2027 | 2 articles | Viewed by 999 | Submission Open

Keywords: acute and chronic liver disease; cirrhosis; risk stratification; emerging therapies; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Acute Myeloid Leukemia: From Molecular Complexity to Precision Medicine

edited by Matteo Molica

submission deadline 20 Jan 2027 | 1 articles | Viewed by 923 | Submission Open

Keywords: acute myeloid leukemia; molecular diagnostics; targeted therapy; measurable residual disease; risk stratification

(This special issue belongs to the Section Hematology)

Neuroinflammation and Neuroimmunology in Neurological Disorders

edited by Łukasz A. Poniatowski

submission deadline 20 Jan 2027 | 1 articles | Viewed by 896 | Submission Open

Keywords: neuroinflammation; neuroimmunology; neurodegenerative diseases; Parkinson’s disease; multiple sclerosis; stroke; traumatic brain injury; hydrocephalus; neurosurgical disorders; neurological disorders; biomarkers; clinical diagnosis; management strategies

(This special issue belongs to the Section Clinical Neurology)

Symptoms, Diagnosis and Treatments of Tricuspid Regurgitation

edited by

Diana Ruxandra Hădăreanu

and Cristina Florescu

submission deadline 20 Jan 2027 | 1 articles | Viewed by 834 | Submission Open

Keywords: tricuspid regurgitation; right heart failure; echocardiography; multimodality cardiac imaging; valvular heart disease; tricuspid valve surgery; transcatheter edge-to-edge repair

(This special issue belongs to the Section Cardiology)

Oral Autoimmune Diseases: Diagnosis and Clinical Management

edited by Zuzanna Ślebioda

submission deadline 20 Jan 2027 | 1 articles | Viewed by 729 | Submission Open

Keywords: Sjögren syndrome; lupus erythematous; lichen planus; Behçet’s disease; recurrent aphthous stomatitis; pemphigus vulgaris; mucous membrane pemphigoid; autoimmune disease; oral mucosa

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Research Progress in Atrial Fibrillation

edited by

Roddy Hiram

submission deadline 20 Jan 2027 | 1 articles | Viewed by 710 | Submission Open

Keywords: atrial fibrillation; atrial arrhythmias; cardiac fibrosis; inflammation; electrical remodeling

(This special issue belongs to the Section Cardiology)

Hysterectomy Surgery—Recent Developments and Emerging Trends

edited by

Anastasia Prodromidou

Themos Grigoriadis

and Dimitrios Zacharakis

submission deadline 20 Jan 2027 | Viewed by 659 | Submission Open

Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care

(This special issue belongs to the Section Obstetrics & Gynecology)

Foot and Ankle Fracture Management and Complication Insights

edited by Jaeho Cho

submission deadline 20 Jan 2027 | 1 articles | Viewed by 633 | Submission Open

Keywords: foot and ankle fractures; clinical anatomy; trauma management; post-traumatic arthritis; surgical techniques

(This special issue belongs to the Section Orthopedics)

Innovations, Biomarkers, and Challenges in Cancer Immunotherapy

edited by

Mohammad Mousaei Ghasroldasht

and Mahzad Akbarpour

submission deadline 20 Jan 2027 | Viewed by 508 | Submission Open

Keywords: next-generation cellular therapies; CAR-NK cell therapy; CAR-T cell therapy; combination strategies; exosomes; T-cell engagers; oncolytic viruses; cancer immunotherapy; biomarkers for therapy response; translational immunotherapy; tumor microenvironment modulation; immune evasion mechanisms

(This special issue belongs to the Section Oncology)

Displaying special issue 601-650 on page 13 of 30.

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