Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
2.9
Journals
JCM
Special Issues
New Advances in Congenital Heart Disease
jcm-logo
Submit to Special Issue Submit Abstract to Special Issue Review for JCM Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

New Advances in Congenital Heart Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 672

Special Issue Editor

Dr. Efrén Martínez-Quintana

E-Mail Website
Guest Editor
Department of Cardiology, Complejo Hospitalario Universitario Insular-Materno Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
Interests: congenital heart disease; pulmonary arterial hypertension; complexity; cyanosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Congenital heart disease (CHD) is the most common congenital anomaly worldwide. Advances in diagnosis, medical therapy, surgery, and interventional procedures have dramatically improved survival, allowing most patients to reach adulthood. Despite these successes, the lifelong complexity and heterogeneity of CHD continue to pose significant clinical challenges, requiring individualized, patient-centered approaches throughout all stages of life.

This Special Issue, New Advances in Congenital Heart Disease, invites high-quality contributions highlighting recent progress in the management of CHD with a focus on practical and clinical aspects. We encourage submissions presenting original investigations, comprehensive reviews, or evidence-based clinical insights addressing CHD in both pediatric and adult populations, as well as studies from related specialties involved in congenital heart care. Topics of interest include surgical and interventional innovations, optimization of medical therapies, prevention and management of complications, long-term outcomes, transition of care, and strategies to enhance quality of life. Contributions exploring genetics, imaging, or other emerging tools as complementary approaches to clinical care are also welcome.

Our goal is to provide an updated and comprehensive resource for clinicians and researchers, fostering collaboration and the exchange of knowledge across the spectrum of CHD care. We warmly invite you to contribute your expertise and insights, helping to advance the field and improve outcomes for this growing patient population.

Dr. Efrén Martínez-Quintana
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • congenital heart disease
  • pediatric cardiology
  • adult congenital heart disease
  • cardiac surgery
  • interventional cardiology
  • long-term outcomes
  • cardiac imaging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

10 pages, 241 KB  
Article
Sex-Based Clinical Outcomes Following Percutaneous Closure of Patent Foramen Ovale
by Giulia Santagostino Baldi, Sebastiano Gili, Giovanni Teruzzi, Giuseppe Calligaris, Piero Montorsi and Daniela Trabattoni
J. Clin. Med. 2026, 15(3), 957; https://doi.org/10.3390/jcm15030957 (registering DOI) - 24 Jan 2026
Abstract
Objectives: Although sex differences have been emphasized in stroke and congenital heart disease, there has been limited investigation into their role in patent foramen ovale (PFO) closure for secondary prevention of stroke. We aimed to explore differences by sex in baseline profiles, procedural [...] Read more.
Objectives: Although sex differences have been emphasized in stroke and congenital heart disease, there has been limited investigation into their role in patent foramen ovale (PFO) closure for secondary prevention of stroke. We aimed to explore differences by sex in baseline profiles, procedural characteristics, and short-term outcomes of patients undergoing transcatheter PFO closure. Methods: A retrospective analysis was conducted on 458 consecutive patients (265 women and 193 men) treated with PFO closure at Centro Cardiologico Monzino in Milan between 2006 and 2011. Baseline information included demographic characteristics, medical history, diagnostic and procedural information, and periprocedural complications. Post-closure outcomes were assessed at index hospitalization and during the first follow-up. Results: The indications for PFO closure were as follows: cryptogenic stroke/TIA in 78% of women vs. 88% of men (p = 0.04). Positive thrombophilic screening was observed in 16% of women vs. 19% of men (non-significant). We observed age-matched (mean age 44 ± 12 years) patients without sex-related differences in baseline and procedural characteristics, with the exception of greater arterial hypertension in women. The mean follow-up time was 13 years for both groups. Recurrent stroke was observed in 0.1% and TIA observed in 0.4% of the ‘cryptogenic stroke/TIA’ group; in the ‘other indications’ group, 1.4% experienced stroke and no TIA was reported. No significant differences were present between sexes. Conclusions: There were no differences in procedural and short-term outcomes between males and females undergoing transcatheter PFO closure, but significant baseline differences in risk factors were identified. There is a critical need for long-term, systematic studies to understand sex and gender differences in the PFO population. Full article
(This article belongs to the Special Issue New Advances in Congenital Heart Disease)
12 pages, 441 KB  
Article
Dyslipidemia Patterns in Adults with Congenital Heart Disease: Focus on HDL Cholesterol
by Efrén Martínez-Quintana and Fayna Rodríguez-González
J. Clin. Med. 2025, 14(23), 8357; https://doi.org/10.3390/jcm14238357 - 25 Nov 2025
Viewed by 489
Abstract
Introduction: As survival in congenital heart disease (CHD) improves, identifying modifiable cardiovascular risk factors like dyslipidemia becomes increasingly important, though its features in adult CHD remain understudied. Methods: A retrospective study of 521 CHD patients (mean age 34 ± 14 years, 58% male) [...] Read more.
Introduction: As survival in congenital heart disease (CHD) improves, identifying modifiable cardiovascular risk factors like dyslipidemia becomes increasingly important, though its features in adult CHD remain understudied. Methods: A retrospective study of 521 CHD patients (mean age 34 ± 14 years, 58% male) and 1782 matched controls (mean age 33 ± 11 years, 55% male) was conducted. Lipid profiles were assessed cross-sectionally at a single time point, and arterial thrombosis events were recorded over a mean follow-up of 5.8 years. Results: CHD patients had significantly lower total cholesterol (164.5 vs. 180.6 mg/dL), LDL (94.9 vs. 107.0 mg/dL), HDL (49.7 vs. 53.1 mg/dL), and triglycerides (97.0 vs. 102.4 mg/dL) compared to controls (all p < 0.05). Low HDL cholesterol (<40 mg/dL) was observed in 20% of CHD patients, nearly double the prevalence in the control group (11.6%; p < 0.001). This abnormality increased with CHD complexity: 15.2% in simple, 22.6% in moderate, and 28.9% in complex lesions. The proportion of patients with HDL < 40 mg/dL was higher in those with ventricular hypoplasia and Eisenmenger syndrome (p = 0.027). These groups also exhibited significantly higher NT-pro BNP levels, with a trend toward elevated C-reactive protein (CRP). Arterial thrombosis occurred in 4.0% of CHD patients versus 0.5% of controls (p < 0.001), with no significant differences between CHD subtypes. While overall lipid parameters did not differ significantly, the combination of low HDL and high LDL levels (mixed LDL + HDL pattern) was more common among patients with thrombosis (p = 0.005), although this association lost significance in binary logistic regression analysis. Conclusions: CHD patients exhibit a distinct lipid profile marked by lower HDL levels, particularly in complex cases and high-risk subtypes. Although the mixed low HDL/high LDL pattern was linked to thrombosis, this association was not maintained in multivariable analysis. Full article
(This article belongs to the Special Issue New Advances in Congenital Heart Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop