Advances in Male Infertility: Diagnosis, Management and ART Integration

Dear Colleagues,

In recent years, significant progress has been made in the field of male infertility, leading to improvements in diagnostic precision, therapeutic interventions, and the application of assisted reproductive technologies (ARTs). This Special Issue, entitled "Advances in Male Infertility: Diagnosis, Management and ART Integration," seeks to highlight cutting-edge research and clinical innovations that are transforming our understanding and treatment of male reproductive dysfunction.

The Special Issue will explore breakthroughs in genetic and epigenetic testing, hormonal profiling, and advanced semen analysis, offering novel insights into the identification of both overt and subclinical etiologies, including chromosomal abnormalities, Y-chromosome microdeletions, and mitochondrial dysfunction. Emphasis will be placed on the role of personalized treatment strategies, such as hormone modulation, antioxidant therapy, and surgical sperm retrieval techniques, including microdissection testicular sperm extraction (micro-TESE).

A key focus will be on the evolving integration of intracytoplasmic sperm injection (ICSI) and its impact on fertility outcomes in cases of severe male factor infertility. Additionally, the Special Issue will address emerging sperm selection and preservation techniques, including the use of microfluidics, magnetic-activated cell sorting (MACS), and cryopreservation innovations.

Importantly, this Special Issue will also welcome contributions on emerging frontiers, such as stem cell therapy, exosome-based diagnostics, and the potential of gene editing to restore spermatogenesis. By fostering a multidisciplinary perspective—bridging urology, andrology, endocrinology, genetics, and reproductive medicine—this Special Issue aims to promote a more integrated and translational approach to male infertility care.

Dr. Despoina Mavrogianni
Dr. Sofoklis Stavros
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.