Acute and Chronic Heart Failure: Clinical Updates and Perspectives—2nd Edition

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue entitled “Acute and Chronic Heart Failure: Clinical Updates and Perspectives—2nd Edition”. In our previous Special Issue, entitled “Acute and Chronic Heart Failure: Clinical Updates and Perspectives”, we published high-quality original research articles and review papers covering a wide range of topics. This second edition represents the continuation of this series.

Heart failure (HF) represents a twenty-first century cardiovascular epidemic, with over 25 million cases worldwide. The increase in HF cases is partly ascribable to the "paradoxical" advancement of treatments for cardiovascular diseases, with a consequent reduction in mortality and higher incidence of cardiac dysfunction among survivors, partly due to the increase in the longevity of the general population. The prognosis of patients with HF remains poor, with one in nine patients dying one year after diagnosis and about one half dying within five years; moreover, despite appropriate medical treatment, many patients face frequent hospitalization and a reduced quality of life. Furthermore, even when symptoms are controlled, subclinical disease progression can occur due to the underlying neurohormonal imbalance.

In recent decades, several advancements have been made in HF treatment. Pharmacological therapy, alongside well-established therapies, has seen the introduction of new molecules. These molecules have now largely entered clinical practice and are recognized in international guidelines, such as valsartan/sacubitril, SGLT2 inhibitors, and more recent drugs such as vericiguat. Furthermore, device-based therapy has seen a significant improvement, with the development of more efficient systems of cardiac pacing and resynchronization therapy, as well as the production of continuously more efficient and less invasive percutaneous assist devices to improve outcomes and enable survival, even in the patients with the most critical conditions.

Despite these advancements, the prognosis and quality of life for patients with HF often remain poor, and there is an urgent need for further studies. Therefore, the aim of this Special Issue is to provide insights into the latest advancements in all aspects of heart failure treatment in both acute and chronic settings. In particular, original research articles and valuable reviews concerning the newest progress in HF are welcome.

Dr. Luigi Cappannoli
Dr. Cristina Aurigemma
Guest Editors

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• acute heart failure
• chronic heart failure
• devices
• drug therapy
• percutaneous ventricular assist devices
• cardiogenic shock
• arrhythmias
• ischemic heart disease

• Acute and Chronic Heart Failure: Clinical Updates and Perspectives in Journal of Clinical Medicine (7 articles)