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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Myeloid-Derived Suppressor and Innate Immune Cells in Hematologic, Malignant and Chronic Diseases

edited by

Helen A. Papadaki

submission deadline 25 Mar 2026 | Viewed by 196 | Submission Open

Keywords: myeloid-derived suppressor cells (MDSCs); macrophages; monocytes; eosinophils; neutrophils; malignancy; cancer; autoimmunity; infection; chronic inflammation; therapeutic target; biomarker; precision medicine; molecular pathways; bone marrow microenvironment

(This special issue belongs to the Section Hematology)

Gastrointestinal Perforations: Diagnosis and Management to Reduce Morbidity and Mortality

edited by

Rossella Reddavid

submission deadline 25 Mar 2026 | Viewed by 186 | Submission Open

Keywords: gastrointestinal perforation; diagnosis; surgery; acute peritonitis; sepsis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

State of the Art in Clinical Management of Sedation and Anesthesia Challenges

edited by Basavana Goudra

submission deadline 25 Mar 2026 | Viewed by 159 | Submission Open

Keywords: anesthesia; oxygenation; sedative agents; ventilation; airway management

(This special issue belongs to the Section Anesthesiology)

"Visceral Aneurysm" in 2025: Recent Advances and Treatment (Second Edition)

edited by Enrico Maria Marone

submission deadline 25 Mar 2026 | Viewed by 148 | Submission Open

Keywords: visceral aneurysms; vascular surgery; endovascular treatment; lparoscopic surgery; robotic surgery; embolization; flow-diverting stents; covered stents

(This special issue belongs to the Section Vascular Medicine)

Breast MRI: An Update

edited by

Filippo Pesapane

and

Anna Rotili

submission deadline 25 Mar 2026 | Viewed by 130 | Submission Open

Keywords: breast cancer; breast imaging; magnetic resonance imaging; diffusion-weighted imaging; contrast-enhanced sequences; artificial intelligence

(This special issue belongs to the Section Obstetrics & Gynecology)

Meibomian Gland Dysfunction and Dry Eye Diseases

edited by

Reiko Arita

and

KyoungYul Seo

submission deadline 25 Mar 2026 | Viewed by 126 | Submission Open

Keywords: meibomian gland; meibomian gland dysfunction; dry eye disease; ocular surface; meibography; lipid layer; tear film; inflammation; therapy; diagnosis; epidemiology; clinical study

(This special issue belongs to the Section Ophthalmology)

Osteosarcoma: New Insights into Diagnosis and Treatment

edited by Lars M. Wagner

submission deadline 25 Mar 2026 | Viewed by 101 | Submission Open

Keywords: osteosarcoma; tyrosine kinase inhibitors; immunotherapy; clinical trial design; intratumoral heterogeneity; liquid biopsy; metastasectomy; deep learning; translational research; targeted therapy

(This special issue belongs to the Section Oncology)

Endocarditis: Clinical Updates on Diagnosis, Treatment and Management

edited by Katarzyna Holcman

submission deadline 25 Mar 2026 | Viewed by 100 | Submission Open

Keywords: infective endocarditis; PET; SPECT; echocardiography; antimicrobial therapy; cardiac surgery; multimodality imaging

(This special issue belongs to the Section Cardiology)

Advances in Schizophrenia and Related Psychotic Disorders

edited by Giovanni Camardese and Michele Ribolsi

submission deadline 25 Mar 2026 | Viewed by 97 | Submission Open

Keywords: psychosis; schizophrenia; severe mental illness; psychopharmacology; negative symptoms; antipsychotics

(This special issue belongs to the Section Mental Health)

Artificial Intelligence in Acute Care Surgery and Trauma Health Care

edited by

Sergio M. Navarro

and Daniel Stephens

submission deadline 25 Mar 2026 | Viewed by 97 | Submission Open

Keywords: artificial neural networks; robotic surgery; virtual reality; augmented reality; artificial intelligence; virtual reality; deep learning

(This special issue belongs to the Section Emergency Medicine)

Contemporary Trends in Cardiovascular Prevention

edited by Alessandro Durante and

Alessandro Mazzapicchi

submission deadline 25 Mar 2026 | Viewed by 90 | Submission Open

Keywords: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia

(This special issue belongs to the Section Cardiovascular Medicine)

Diagnosis and Treatment for Hearing Loss: Expert Views

edited by

Robert A. Saadi

and John L. Dornhoffer

submission deadline 25 Mar 2026 | Viewed by 85 | Submission Open

Keywords: hearing loss; cochlear implants; hearing aid technology; regenerative medicine; diagnostic audiology

(This special issue belongs to the Section Otolaryngology)

Clinical Management of Vestibular Disorders

edited by

Eun-ju Jeon

and Sun-Young Oh

submission deadline 25 Mar 2026 | Viewed by 81 | Submission Open

Keywords: vestibular disorders; vertigo; dizziness; balance; BPPV; vestibular rehabilitation; telemedicine; multidisciplinary care

(This special issue belongs to the Section Otolaryngology)

Pulmonary Embolism: Bridging Cutting-Edge Research and Clinical Practice

edited by

Bedros Taslakian

and Vivian Lee Bishay

submission deadline 25 Mar 2026 | Viewed by 78 | Submission Open

Keywords: pulmonary embolism; catheter-directed thrombectomy; catheter-directed thrombolysis; post-pulmonary embolism syndrome; chronic thromboembolic disease; chronic thromboembolic pulmonary hypertension

(This special issue belongs to the Section Respiratory Medicine)

From Heart to Brain: Interdisciplinary Perspectives on Cerebral Infarction

edited by

Laurent Suissa

and Jean-Claude Deharo

submission deadline 25 Mar 2026 | Viewed by 75 | Submission Open

Keywords: ischemic stroke; cardioembolic stroke; atrial fibrillation; heart– brain axis; neurocardiology; post-stroke cardiac dysfunction; stroke prevention; cerebral infarction; cardiac monitoring in stroke; secondary stroke prevention

(This special issue belongs to the Section Clinical Neurology)

Hematologic Malignancies: Treatment Strategies and Future Challenges: 2nd Edition

edited by Masaaki Noguchi

submission deadline 25 Mar 2026 | Viewed by 65 | Submission Open

Keywords: hematologic malignancies; relapse; refractory; drug resistance; therapeutic strategies; new target; biomarkers; new insights

(This special issue belongs to the Section Hematology)

Dentistry and Oral Surgery: Current Status and Future Prospects

edited by

Dragana Gabrić

Ivona Bago

and

Marko Vuletić

submission deadline 26 Mar 2026 | 5 articles | Viewed by 7457 | Submission Open

Keywords: dentistry; oral surgery; dental implantology; prosthodontics; restorative dentistry; periodontology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Ocular Surface, Retina, and Choroid as Mirrors of Systemic and Genetic Diseases

edited by

Giacomo Visioli

Alisi Ludovico

and

Alessandro Lambiase

submission deadline 27 Mar 2026 | 4 articles | Viewed by 10367 | Submission Open

Keywords: ocular surface; retina; choroid; systemic diseases; genetic conditions; biomarkers; diagnostic imaging; neuroretina; infectious diseases

(This special issue belongs to the Section Ophthalmology)

Current Progress in the Treatment of Cornea and Ocular Surface Diseases

edited by Marco Messina and

Giuseppe Giannaccare

submission deadline 27 Mar 2026 | 2 articles | Viewed by 3126 | Submission Open

Keywords: dry eye disease; meibomian gland dysfunction; microbial keratitis; auto-immune keratitis; peripheral ulcerative keratitis; neurotrophic keratopathy; corneal dystrophies; corneal degenerations; mucous membrane pemphigoid; ocular cicatricial disease; Stevens– Johnson syndrome; pterygium; ocular graft-versus-host disease; limbal stem cell deficiency; keratoplasty; amniotic membrane transplantation; keratoconus; corneal collagen cross-linking; antimicrobial therapy; corneal neurotization; vernal keratoconjunctivitis; atopic keratoconjunctivitis

(This special issue belongs to the Section Ophthalmology)

Vascular and Endovascular Surgery: Current Progress and Future Challenges

edited by Michael Keese and Martin Sigl

submission deadline 28 Mar 2026 | 5 articles | Viewed by 7374 | Submission Open

Keywords: vascular; endovascular; surgery; therapy; aneurysm; vascular; PAD; venous; interdisciplinary

(This special issue belongs to the Section Vascular Medicine)

Clinical Management and Treatment of Orthopedic Oncology: 2nd Edition

edited by

Muhammad Umar Jawad

and Danielle Elizabeth Greig

submission deadline 28 Mar 2026 | 5 articles | Viewed by 4068 | Submission Open

Keywords: bone metastasis; primary bone tumors; soft tissue sarcoma; limb salvage; multimodal treatment strategies

(This special issue belongs to the Section Orthopedics)

Degenerative Cervical Myelopathy and Traumatic Spinal Cord Injury: Recent Advances and Future Directions

edited by Nader Hejrati,

Michael G. Fehlings

and Maryam Seif

submission deadline 28 Mar 2026 | 1 articles | Viewed by 1809 | Submission Open

Keywords: degenerative cervical myelopathy; traumatic spinal cord injury; clinical assessment; surgical management; non-operative management; neuroprotective therapies; neuroregenerative therapies; outcome prediction

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Cholecystitis and Complications

edited by Dimitrios Balalis,

Dimitrios K. Manatakis

and Nikolaos Vassos

submission deadline 28 Mar 2026 | 1 articles | Viewed by 821 | Submission Open

Keywords: gallbladder; cholecystitis; right upper quadrant pain; ultrasound; laparoscopic approach

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Novel Research in the Management of Cardiac Arrest

edited by Giovanni Babini and

Alberto Cucino

submission deadline 28 Mar 2026 | Viewed by 746 | Submission Open

Keywords: cardiac arrest; post-cardiac arrest syndrome; resuscitation; temperature control; target temperature management; neuroprotection; neuroprognostication; defibrillation; extracorporeal life support

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis, Treatment of Intestinal Cancer: 2nd Edition

edited by

Eyal Klang

and

Adi Lahat

submission deadline 28 Mar 2026 | Viewed by 228 | Submission Open

Keywords: colorectal cancer; early detection; treatment; immune therapy; radiation therapy; chemotherapy; risk factors; improved prognosis

(This special issue belongs to the Section Oncology)

Mitral Valve Stenosis or Aortic Valve Stenosis: Progress from Diagnosis to Treatment

edited by Francesco Melillo

submission deadline 28 Mar 2026 | Viewed by 116 | Submission Open

Keywords: aortic stenosis; mitral stenosis; TAVI

(This special issue belongs to the Section Cardiology)

Management of Female Pelvic Floor Disorders and Incontinence

edited by Luis López Fando

submission deadline 28 Mar 2026 | Viewed by 111 | Submission Open

Keywords: pelvic floor disorders; urinary incontinence; pelvic organ prolapse; reconstructive urology; voiding dysfunction; multidisciplinary care; surgical techniques; urodynamics; patient-centered outcomes; digital learning in urology

(This special issue belongs to the Section Nephrology & Urology)

The “Orthogeriatric Fracture Syndrome”—Issues and Perspectives

edited by

Johannes Dominik Bastian

submission deadline 31 Mar 2026 | 19 articles | Viewed by 30191 | Submission Open

Keywords: geriatric trauma; fragility fracture; orthogeriatric; co-management; assessment; integrated care; osteoporosis; sarcopenia; frailty; gait disturbance; fall; rehabilitation; prehabilitation; prevention; ehealth; digitalization

(This special issue belongs to the Section Orthopedics)

Challenges in Minimally Invasive Colorectal and Abdominal Wall Surgery

edited by Francesco Ferrara and

Roberto Peltrini

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3850 | Submission Open

Keywords: colorectal surgery; laparoscopy; abdominal wall surgery; hernia; diastasis recti; surgical oncology; rectal tumor; colon tumor; colorectal neoplasia

(This special issue belongs to the Section General Surgery)

Advances in Perioperative Care: Challenges and Perspectives in Enhanced Recovery After Surgery, Perioperative Optimization and Prehabilitation: 2nd Edition

edited by

Carlos Cerdán Santacruz

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1508 | Submission Open

Keywords: perioperative care; enhanced recovery after surgery; prehabilitation; minimally invasive surgery; patient-related outcome measures; colorectal surgery; general surgery; thoracic surgery; vascular surgery; optimal functional recovery

(This special issue belongs to the Section General Surgery)

Recent Clinical Perspective in Kidney Transplantation

edited by Nikolina Bašić-Jukić

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1287 | Submission Open

Keywords: kidney transplantation; outcomes; desensitization; xenotransplantation; transplant nephropathology; multiorgan transplantations; post-transplant complications; inequities in transplantation

(This special issue belongs to the Section Nephrology & Urology)

Artificial Intelligence in Women’s Health and Medicine: Improving Clinical Practice, Diagnosis, Treatment Management and Patient Experiences

edited by

Shivaram Poigai Arunachalam

and Nasibeh Zanjirani Farahani

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1210 | Submission Open

Keywords: women’ s health; artificial intelligence; machine learning; personalized medicine; reproductive health; health equity; social determinants of health; mental health; cancer; cardiovascular disease

(This special issue belongs to the Section Epidemiology & Public Health)

Acute Trauma and Trauma Care in Orthopedics: 2nd Edition

edited by

Pietro Maniscalco

and

Gianfilippo Caggiari

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1108 | Submission Open

Keywords: orthopedics; trauma; injury; musculoskeletal; surgery; knee; osteoarthritis; spinal deformity; fracture; joint replacement; hip fractur; fragility fracture; minimally invasive surgery; post-traumatic care and rehabilitation; pain management; emergency assessment

(This special issue belongs to the Section Orthopedics)

Paradigm Changes in Cardiac Surgery and Interventional Cardiology

edited by

Miklos Bitay

submission deadline 31 Mar 2026 | 1 articles | Viewed by 866 | Submission Open

Keywords: cardiac surgery; trans-catheter interventions; ischaemic heart disease; structural heart disease; electrophysiological interventions; state-of-the-art techniques; golden standards; therapeutic guidelines

(This special issue belongs to the Section Cardiology)

JSOPB 2025–2026 Congress Special Issue–Update on Organ Preservation and Transplantation

edited by

Issei Saitoh

and

Takashi Kenmochi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 843 | Submission Open

Keywords: organ preservation; transplantation; pharmacology; engineering; stem cell therapy

(This special issue belongs to the Section General Surgery)

New Insights into Clinical Application of Embolization Techniques

edited by

Bedros Taslakian

and Yan Epelboym

submission deadline 31 Mar 2026 | 1 articles | Viewed by 702 | Submission Open

Keywords: embolization; interventional radiology; musculoskeletal embolization; uterine artery embolization; prostate artery embolization; vascular malformations; catheter-directed therapy

(This special issue belongs to the Section Vascular Medicine)

Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition

edited by

Vera Geraldes

and

Isabel Rocha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 695 | Submission Open

Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms

(This special issue belongs to the Section Cardiology)

Advancements in Lumbar Spine Surgery: Modern Strategies and Techniques

edited by Christian von der Brelie and Frank Beyer

submission deadline 31 Mar 2026 | 1 articles | Viewed by 416 | Submission Open

Keywords: lumbar spine; spine surgery; new techniques; robotics; minimally-invasive; artificial intelligence (AI); navigation

(This special issue belongs to the Section Orthopedics)

Pregnancy and Delivery Complications: Bridging Research and Clinical Practice

edited by

Maria Patricia Roman

, Andrei Mihai Malutan and Răzvan Ciortea

submission deadline 31 Mar 2026 | Viewed by 117 | Submission Open

Keywords: maternal– fetal medicine; obstetric complications; perinatal health; pelvic floor disorders; childbirth perineal trauma; risk stratification; patient-reported outcomes; patient-reported outcome measures

(This special issue belongs to the Section Obstetrics & Gynecology)

Latest Advances in Glaucoma, Cataracts, and Refractive Surgery

edited by

Adrian Gericke

, Felix Wagner and

Julia Verena Stingl

submission deadline 31 Mar 2026 | Viewed by 112 | Submission Open

Keywords: glaucoma; cataract surgery; refractive surgery; minimally invasive glaucoma surgery (MIGS); laser vision correc-tion (LVC); keratorefractive lenticule extraction (KLEx); lenticule implantation; multifocal IOLs; extended depth-of-focus (EDOF) lenses; ocular imaging; optical coherence tomography (OCT); artificial intelligence in ophthalmology; corneal biomechanics; surgical innovation

(This special issue belongs to the Section Ophthalmology)

Thoracic Radiochemoimmunotherapy for Non-Small Cell Lung Cancer (NSCLC): Evolving Techniques and Clinical Applications

edited by

Franz Zehentmayr

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: radiotherapy; radiology; oncology; non-small cell lung cancer; real-world data; immunotherapy; radiation dose escalation

(This special issue belongs to the Section Oncology)

Endodontic Diseases: Prevalence, Risk Factors, and Treatment Outcomes

edited by Iris Slutzky-Goldberg, Shlomo Matalon and

Hagay Slutzky

submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open

Keywords: cone beam computed tomography (cbct); diagnostic tools; endodontic therapy; peri-radicular pathologies; regenerative endodontics; risk factors; systemic disease; treatment outcome; vital pulp therapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Laser Dentistry: Emerging Therapeutic Concepts

edited by

Satoshi Watanabe

and Risako Mikami

submission deadline 31 Mar 2026 | Viewed by 91 | Submission Open

Keywords: laser dentistry; dental treatment guidelines; refractory endodontic infection; root canal therapy; minimally invasive endodontics; anatomy; cone-beam computed tomography

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Oral Biology: Advances of Translating Experimental Findings into Clinical Dentistry and Oral Medicine

edited by

Andrea Palermo

submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open

Keywords: oral surgery; biomaterials; tissue engineering; regenerative medicine; dentistry dentin graft; growth factors; ad-vances orthodontics; skeletal anchorage with miniscrews; TADS; MADS; MARPE; aligner

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Emerging Treatment Options in Atrial Fibrillation

edited by Hoang Nhat Pham and Amitoj Singh

submission deadline 31 Mar 2026 | Viewed by 79 | Submission Open

Keywords: atrial fibrillation; AF ablation; lifestyle intervention; rhythm control; pulsed field ablation; antiarrhythmic drugs; direct oral anticoagulants

(This special issue belongs to the Section Cardiology)

Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities

edited by

Danilo Menichelli

and Flavio Giuseppe Biccirè

submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open

Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy

(This special issue belongs to the Section Cardiology)

Glaucoma: Diagnosis and Management Insights

edited by

Stamatios Lampsas

and Eythimios Karmiris

submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open

Keywords: glaucoma; risk factors; progression; novel biomarkers; diagnosis; management

(This special issue belongs to the Section Ophthalmology)

Current Challenges and Updates in Therapeutic Advancements of Prostatectomy

edited by

Luca Lambertini

and

Francesco Lasorsa

submission deadline 31 Mar 2026 | Viewed by 69 | Submission Open

Keywords: radical prostatectomy; robot-assisted surgery; single port; artificial intelligence; complications; same day discharge; learning curve; training models; outcomes

(This special issue belongs to the Section Nephrology & Urology)

New Insights into Cardiovascular Radiology

edited by Amalia Lupi and Riccardo Cau

submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open

Keywords: CMR; tissue characterization; 4Dflow; CCTA; photon counting CT; plaque characterization

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Acute Care Surgery: The Evolution of a Modern Specialty

edited by Mayur Narayan

submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open

Keywords: acute care surgery; emergency surgery; health equity; global surgery; trauma care; surgical workforce; surgical in-novation; decision-making

(This special issue belongs to the Section Emergency Medicine)

Displaying special issue 901-950 on page 19 of 32.

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