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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Dysregulation Across the Spectrum from Anorexia Nervosa to Obesity

edited by Andriana C. Kaliora

submission deadline 20 Jan 2026 | Viewed by 271 | Submission Open

Keywords: metabolic dysregulation; anorexia nervosa; obesity; environmental factors in metabolic health; gut microbiota and metabolism; hormonal regulation of appetite; inflammation and metabolic disorders; dietary influence on metabolism

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Updates and Current Challenges in Obstetrical Anesthesia

edited by Michael Froelich

submission deadline 20 Jan 2026 | Viewed by 254 | Submission Open

Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care

(This special issue belongs to the Section Obstetrics & Gynecology)

Innovations and Evolution of Extracorporeal Organ Support in Critical Care

edited by

Francesco Alessandri

Giovanni Giordano

and Antonella Tosi

submission deadline 20 Jan 2026 | Viewed by 247 | Submission Open

Keywords: critical care; extracorporeal organ support; critical care nephrology; cardiology; ARDS; sepsis; blood purification; liver support

(This special issue belongs to the Section Intensive Care)

Haemophilia: Current Treatment and Clinical Outcomes, Challenges and Opportunities: 2nd Edition

edited by

Ezio Zanon

submission deadline 20 Jan 2026 | Viewed by 217 | Submission Open

Keywords: haemophilia A and B; FVIII EHL; FIX EHL; prophylaxis; emicizumab; health-related quality of life; population pharmacokinetics

(This special issue belongs to the Section Hematology)

Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)

edited by Diana Alecsandru

submission deadline 20 Jan 2026 | Viewed by 214 | Submission Open

Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Bronchoscopy and Interventional Pulmonology

edited by Bryan S. Benn and

Jonathan Kurman

submission deadline 20 Jan 2026 | Viewed by 210 | Submission Open

Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction

(This special issue belongs to the Section Respiratory Medicine)

From Dual Diagnosis to Dual Disorder(s): Bridging Comorbidity and Integrated Clinical Understanding

edited by

Angelo Giovanni Icro Maremmani

submission deadline 20 Jan 2026 | Viewed by 195 | Submission Open

Keywords: dual diagnosis; dual disorder; psychiatric comorbidity; addiction; integrated care; self-medication; substance use; mental illness; treatment models

(This special issue belongs to the Section Mental Health)

Cardiac and Pulmonary Involvements in High-Risk Neonatal Cohorts: Short- and Long-Term Issues

edited by Arvind Sehgal

submission deadline 20 Jan 2026 | Viewed by 194 | Submission Open

Keywords: fetal growth restriction; lung disease; cardiac maladaptation; placenta; public health; neurodevelopment; long term; adulthood; Barker’ s hypothesis; newborn; vascular

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Application of Echocardiography in Heart Disease: 2nd Edition

edited by

Carlos Cotrim

submission deadline 20 Jan 2026 | Viewed by 152 | Submission Open

Keywords: transthoracic echocardiography; transesophageal echocardiography; stress echocardiography; valve disease; coronary artery disease; myocardial disease; pericardial disease; aortic disease; congenital heart disease

(This special issue belongs to the Section Cardiology)

Preventive Strategies and Novel Treatments for Rheumatoid Arthritis

edited by

Vincent Goeb

submission deadline 20 Jan 2026 | Viewed by 151 | Submission Open

Keywords: rheumatoid arthritis; antibodies; biologics; JAK; environment; susceptibility; therapeutic strategies

(This special issue belongs to the Section Immunology & Rheumatology)

Recent Advances and Future Perspectives of Subarachnoid Hemorrhage

edited by Alexandros Doukas and Athanasios K. Petridis

submission deadline 20 Jan 2026 | Viewed by 147 | Submission Open

Keywords: subarachnoid hemorrhage; neuromonitoring; neurocritical care; neurointerventions; neurointensive care

(This special issue belongs to the Section Clinical Neurology)

New Insights in Trauma and Emergency Surgery

edited by Kai Oliver Jensen and Valentin Neuhaus

submission deadline 20 Jan 2026 | Viewed by 146 | Submission Open

Keywords: trauma and emergency surgery; multiple trauma; orthopedic trauma; surgery; concepts in trauma

(This special issue belongs to the Section Emergency Medicine)

Emerging Trends in Multiple Myeloma

edited by

Despina Fotiou

submission deadline 20 Jan 2026 | Viewed by 142 | Submission Open

Keywords: multiple myeloma; personalized medicine; high-risk disease; cellular therapies; refractory disease

(This special issue belongs to the Section Hematology)

Current Trends and Future Challenges in Heart Failure

edited by Oren Caspi and

Robert Zukermann

submission deadline 20 Jan 2026 | Viewed by 139 | Submission Open

Keywords: heart failure; guideline-directed therapy; digital health; biomarkers; multidisciplinary care; artificial intelligence; cardiorenal syndrome; remote hemodynamic monitoring; cardiac amyloidosis; exercise rehabilitation

(This special issue belongs to the Section Cardiology)

Therapeutic Strategies for Obesity and Diabetes in Cardiovascular Disease Patients

edited by Davide D'Andrea

submission deadline 20 Jan 2026 | Viewed by 138 | Submission Open

Keywords: obesity; diabetes; cardiovascular complications; diabetes management; pharmacological treatment; bariatric surgery; regular monitoring

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Management of Hip Fractures

edited by

Toshiyuki Kawai

submission deadline 20 Jan 2026 | Viewed by 137 | Submission Open

Keywords: hip fracture; internal fixation; hemiarthroplasty; arthroplasty and fixation; osteoporosis management; fracture prevention; multidisciplinary care; surgical treatment; rehabilitation strategies

(This special issue belongs to the Section Orthopedics)

Lung Transplantation: Current Challenges and New Perspectives

edited by Reinaldo E. Rampolla and Pedro A. Catarino

submission deadline 20 Jan 2026 | Viewed by 130 | Submission Open

Keywords: lung transplantation; interstitial lung diseases; pulmonary hypertension; chronic obstructive pulmonary disease; bronchiectasis; extra corporeal membrane oxygenation; robotic lung transplantation

(This special issue belongs to the Section Respiratory Medicine)

Advances in Chronic Pain Research and Therapy

edited by Elena Makovac

submission deadline 20 Jan 2026 | Viewed by 129 | Submission Open

Keywords: chronic pain; pain perception; brain-body interactions; therapeutic effectiveness; integrated approach

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Update on Aortic Valve Disease Treatments

edited by

Giovanni Concistre

submission deadline 20 Jan 2026 | Viewed by 123 | Submission Open

Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation

(This special issue belongs to the Section Cardiology)

Clinical Advances, Opportunities, and Challenges in Digestive Diseases of the Foregut

edited by Valentin Mocanu and

Salvador Navarrete

submission deadline 20 Jan 2026 | Viewed by 118 | Submission Open

Keywords: obesity; achalasia; reflux; malrotation; therapeutic endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Regional Anesthesia in Pain Management

edited by Jaime L. Baratta

submission deadline 20 Jan 2026 | Viewed by 108 | Submission Open

Keywords: acute pain; perioperative medicine; general anesthesiology; regional anesthesia; orthopedic anesthesia; multimodal analgesia

(This special issue belongs to the Section Anesthesiology)

Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults

edited by

Roxana Maria Nemes

submission deadline 20 Jan 2026 | Viewed by 106 | Submission Open

Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors

(This special issue belongs to the Section Respiratory Medicine)

New Clinical Perception of Cardiac Rehabilitation

edited by

Antonello D’Andrea

and Mario Pacileo

submission deadline 20 Jan 2026 | Viewed by 106 | Submission Open

Keywords: cardiac rehabilitation; digital health; exercise therapy; cardiovascular prevention; chronic disease management; psychosocial support; personalized medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Advances in Urologic Oncology: 2nd Edition

edited by Saum Ghodoussipour

submission deadline 20 Jan 2026 | Viewed by 105 | Submission Open

Keywords: bladder cancer; kidney cancer; prostate cancer; testis cancer; penile cancer; minimally invasive; cancer treatment

(This special issue belongs to the Section Nephrology & Urology)

Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies

edited by Alessandro Andreis,

Guglielmo Beccuti

and

Angelo Armandi

submission deadline 20 Jan 2026 | Viewed by 100 | Submission Open

Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology

(This special issue belongs to the Section Cardiology)

Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century

edited by Reinhardt T. Grundmann

submission deadline 20 Jan 2026 | Viewed by 96 | Submission Open

Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation

(This special issue belongs to the Section Cardiovascular Medicine)

The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century

edited by Tomer Ziv-Baran and Elena Izkhakov

submission deadline 20 Jan 2026 | Viewed by 93 | Submission Open

Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach

(This special issue belongs to the Section Epidemiology & Public Health)

Macular Diseases: From Diagnosis to Treatment

edited by

Gabriella De Salvo

submission deadline 22 Jan 2026 | Viewed by 196 | Submission Open

Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers

(This special issue belongs to the Section Ophthalmology)

Personalized Radiological and Surgical Strategies for Breast Cancer Treatment

edited by Vlad Alexandru Gata, Maximilian Muntean and

Roxana Pintican

submission deadline 22 Jan 2026 | Viewed by 76 | Submission Open

Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction

(This special issue belongs to the Section General Surgery)

Application of Artificial Intelligence in Cardiology

edited by

Matthias Unterhuber

submission deadline 23 Jan 2026 | 3 articles | Viewed by 2590 | Submission Open

Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning

(This special issue belongs to the Section Cardiology)

Clinical Advances and New Challenges in Laparoscopic Surgery

edited by Ionut Bogdan Diaconescu and Matei Bratu

submission deadline 23 Jan 2026 | Viewed by 96 | Submission Open

Keywords: laparoscopic surgery; trauma surgery; surgical oncology; abdominal surgery; colorectal surgery; general surgery; minimally invasive surgery; gastrointestinal surgery; hernia surgery; surgery; advance laparoscopic surgery; cancer surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Glaucoma: Current Status and Prospects

edited by Rubén Sánchez-Jean,

Carmen Dora Méndez-Hernández

and Federico Sáenz-Francés San Baldomero

submission deadline 24 Jan 2026 | 2 articles | Viewed by 3466 | Submission Open

Keywords: glaucoma surgery; new techniques; minimally invasive glaucoma surgery; intraocular pressure; optometry; IOLs designs

(This special issue belongs to the Section Ophthalmology)

Pediatric Pulmonology: Recent Developments and Emerging Trends

edited by Athina L. Papadopoulou

submission deadline 25 Jan 2026 | 5 articles | Viewed by 16925 | Submission Open

Keywords: definition of breath sounds; lung– gut axis pathophysiology; disease endotypes and phenotypes; asthma management in children; bronchiolitis spectrum; pediatric bronchopulmonary dysplasia; pulmonary function testing in pediatric patients; pediatric sleep-disordered breathing; neonatal respiratory distress syndrome; childhood interstitial lung diseases; pulmonary hypertension in children; biomarkers in pediatric lung diseases; allergy and the lungs; diagnostic and therapeutic challenges in bronchoscopy; gene therapy in cystic fibrosis

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond

edited by

Rosalinda Madonna

submission deadline 25 Jan 2026 | 5 articles | Viewed by 12450 | Submission Open

Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors

(This special issue belongs to the Section Cardiovascular Medicine)

Personalized Medicine for the Management of Non-Communicable Disease (NCDs)

edited by

Alessandro Mattina

, Giulio Geraci and

Vincenzina Lo Re

submission deadline 25 Jan 2026 | 6 articles | Viewed by 11430 | Submission Open

Keywords: personalized medicine; precision medicine; non-communicable disease; cardiovascular disease; cancer; diabetes; chronic obstructive pulmonary disease; cognitive impairment; atherosclerosis; lipids; inflammation; immunity; therapy

(This special issue belongs to the Section Epidemiology & Public Health)

Male Fertility in the Modern Age: Challenges and Opportunities

edited by

Angelo Marino

submission deadline 25 Jan 2026 | 2 articles | Viewed by 9822 | Submission Open

Keywords: male infertility; semen parameters; sperm selection; IVF/ICSI

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Risks and Perinatal Outcomes in Pregnancy and Childbirth: 2nd Edition

edited by Apostolos Mamopoulos and

Ioannis Tsakiridis

submission deadline 25 Jan 2026 | 5 articles | Viewed by 8708 | Submission Open

Keywords: pregnancy complications; perinatal outcomes; childbirth; hypertension; diabetes; fetal growth restriction; stillbirth; preterm delivery

(This special issue belongs to the Section Obstetrics & Gynecology)

Keratoconus: Current Status and Prospects

edited by

Uxía Regueiro

and Isabel Lema

submission deadline 25 Jan 2026 | 3 articles | Viewed by 8414 | Submission Open

Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances

(This special issue belongs to the Section Ophthalmology)

Prevention, Diagnosis and Treatment of Oral Mucosal Diseases

edited by

Masanobu Abe

submission deadline 25 Jan 2026 | 3 articles | Viewed by 7972 | Submission Open

Keywords: oral mucosal diseases; oral mucositis; oral precancerous lesions; oral cancer; oral potentially malignant disorders; OPMDs; oral leukoplakia

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Foot and Ankle Surgery: Current Advances and Prospects

edited by

Jaeho Cho

submission deadline 25 Jan 2026 | 4 articles | Viewed by 3608 | Submission Open

Keywords: foot and ankle surgery; foot pathologies; ankle disease and trauma; diabetic foot; epidemiology; clinical anatomy; foot orthoses; weight-bearing CT

(This special issue belongs to the Section Orthopedics)

Autism Spectrum Disorder: Diagnosis, Treatment, and Management

edited by

Marios Adamou

submission deadline 25 Jan 2026 | 1 articles | Viewed by 3557 | Submission Open

Keywords: adult autism (including autism spectrum disorders); neurodevelopmental disorders; clinical diagnostics; digital diagnostics; artificial intelligence; multimodal treatments

(This special issue belongs to the Section Mental Health)

Interventional Cardiology—Challenges and Solutions

edited by

Yonggu Lee

submission deadline 25 Jan 2026 | 3 articles | Viewed by 3544 | Submission Open

Keywords: chronic total occlusion; highly calcified coronary or lower extremity arteries; stentless percutaneous coronary intervention; chronic limb threatening ischemia; instent restenosis in the extremity artery diseases; endovascular therapy for pulmonary thromboembolism; transcatheter aortic valve replacemment for the bicuspid aortic valve; transcatheter aortic valve replacement for the valve-in-valve procedure; endovascular therapy for tricospid valve regurgitation; transcatheter edge-to-edge repair for mitral valve regurgitation

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Treatment for Venous Thromboembolism

edited by

Elisavet Grouzi

and Georgia Kaiafa

submission deadline 25 Jan 2026 | 3 articles | Viewed by 3320 | Submission Open

Keywords: venous thromboembolism; anticoagulation; cancer-associated thrombosis; thrombosis in MPNs; thrombosis in multiple myeloma; antiphospholipidic syndrome; thrombosis in PNH; thrombosis in hemoglobinopathies; thrombophilia; pregnancy and thrombophilia; reversal of anticoagulants; thromboprophylaxis

(This special issue belongs to the Section Hematology)

Clinical Updates in Cardiac Electrophysiology: 2nd Edition

edited by Kenneth C. Bilchick

submission deadline 25 Jan 2026 | 1 articles | Viewed by 2904 | Submission Open

Keywords: arrhythmias; atrial fibrillation; cardiac electrophysiology; heart rhythm disorders; ablation; ventricular tachycardia; remote monitoring; digital health; artificial intelligence; cardiac magnetic resonance

(This special issue belongs to the Section Cardiology)

Inflammatory Bowel Diseases: Clinical Advances and Emerging Therapies

edited by

Ewa Malecka-Wojciesko

submission deadline 25 Jan 2026 | 2 articles | Viewed by 2520 | Submission Open

Keywords: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’ s disease; gut inflammation; bowel perforation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis

edited by Grigorios Giamouzis

submission deadline 25 Jan 2026 | 1 articles | Viewed by 2366 | Submission Open

Keywords: cardiac amyloidosis; transthyretin amyloidosis; hypertrophic cardiomyopathy; cardiac imaging; heart failure

(This special issue belongs to the Section Cardiology)

Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition

edited by

Paul Immanuel Heidekrueger

, Peter Niclas Broer and Denis C. Ehrl

submission deadline 25 Jan 2026 | 1 articles | Viewed by 1356 | Submission Open

Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Ocular Surface Disease: Epidemiology, Diagnosis and Management

edited by

Sandeep K. Dhallu

and

Nicole Carnt

submission deadline 25 Jan 2026 | Viewed by 860 | Submission Open

Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Machine Learning and Artificial Intelligence in Neurosurgery

edited by Jan Oliver Neumann and

Paul Naser

submission deadline 25 Jan 2026 | Viewed by 483 | Submission Open

Keywords: artificial intelligence; neurosurgery; neuro-oncology; spinal neurosurgery; neuro-ICU; stereotactic neurosurgery; pre-operative planning

(This special issue belongs to the Section Clinical Neurology)

Shoulder and Elbow Surgery: Clinical Updates and Perspectives

edited by Taku Hatta, Akihiko Hasegawa and Takuma Yuri

submission deadline 25 Jan 2026 | Viewed by 339 | Submission Open

Keywords: rotator cuff injuries; shoulder arthroplasty; elbow surgery; shoulder surgery; shoulder and elbow disease; arthroscopic surgery; orthopedic surgery

(This special issue belongs to the Section Orthopedics)

Displaying special issue 501-550 on page 11 of 31.

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