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Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 January 2026 | Viewed by 76

Special Issue Editor


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Guest Editor
Department of Cardiology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece
Interests: heart failure; coronary artery disease; chronic heart failure; interventional cardiology; PCI; cardiac Catheterization; acute heart failure; myocardial infarction; acute myocardial infarction; cardiac function

Special Issue Information

Dear Colleagues,

Cardiac amyloidosis is a progressive and potentially fatal condition characterized by the deposition of amyloid fibrils in the heart, leading to restrictive cardiomyopathy and heart failure. Early diagnosis and targeted therapy are critical for improving outcomes. This Special Issue, "Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis", aims to provide a comprehensive overview of the latest developments in the diagnosis and treatment of cardiac amyloidosis. We invite contributions that explore a wide range of topics related to cardiac amyloidosis, including original research articles, and reviews. We aim to provide valuable insights that will guide clinicians in improving the diagnosis and treatment of cardiac amyloidosis.

Dr. Grigorios Giamouzis
Guest Editor

Manuscript Submission Information

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Keywords

  • cardiac amyloidosis
  • transthyretin amyloidosis
  • hypertrophic cardiomyopathy
  • cardiac imaging
  • heart failure

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Published Papers (1 paper)

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Review

16 pages, 802 KB  
Review
Transthyretin Amyloid Cardiomyopathy Treatment: An Updated Review
by Dinusha Wanniarachchige, Shazli Khan and Stephen Pan
J. Clin. Med. 2025, 14(17), 6089; https://doi.org/10.3390/jcm14176089 - 28 Aug 2025
Abstract
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive form of restrictive cardiomyopathy caused by the misfolding and deposition of transthyretin protein. What was once a condition that had little by way of treatment other than liver transplantation has now become a manageable disease due [...] Read more.
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive form of restrictive cardiomyopathy caused by the misfolding and deposition of transthyretin protein. What was once a condition that had little by way of treatment other than liver transplantation has now become a manageable disease due to revolutionary novel therapies. This review outlines therapeutic strategies aimed at halting or reversing disease progression. Current approaches include transthyretin (TTR) stabilizers such as tafamidis and acoramidis, as well as TTR silencers such as vutisiran. In addition, novel therapies under clinical investigation are emerging, such as gene-editing strategies and monoclonal antibodies targeting amyloid deposits. The aim of this paper is to investigate the current literature and ongoing clinical trials exploring treatment options for ATTR-CM. Transthyretin stabilizers and RNA silencers improve survival, functional capacity, and quality of life. Early-phase studies of gene-editing and monoclonal antibody therapies demonstrate promising amyloid-lowering effects. Stabilizers and silencers continue to constitute the standard therapy, while gene-editing and monoclonal antibodies offer potential as future treatments. The advent of a multitude of therapies for ATTR-CM holds promise for a future of targeted, personalized medicine for the treatment of this not-so-uncommon cause of heart failure. Full article
(This article belongs to the Special Issue Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis)
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