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Clinical Management of Salivary Gland Disorders
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Clinical Management of Salivary Gland Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1073

Special Issue Editor

Prof. Dr. Masao Yagi

E-Mail Website
Guest Editor
Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan
Interests: head and neck surgery; ENT; otology; endoscopic surgery

Special Issue Information

Dear Colleagues,

Parotidectomy, the surgical removal of lesions, mainly tumours, in the parotid gland, has long been a challenge in terms of the accurate resection of the lesion and minimizing complications. Although not common in other organs, the parotid gland has an internal branching of the facial nerve, thus requiring delicate manipulation to preserve it. The histopathological variety of salivary gland tumours also makes diagnosis and treatment more difficult. Even with the development of nerve monitoring devices, preservation of function is occasionally difficult. Therefore, preoperative and intraoperative diagnosis, especially histopathological characterization, is very important in the handling of the nerves. The challenges in salivary gland treatment are diverse, including surgical techniques, imaging, and pathology, and their development is essential for safe treatment. In addition to surgical treatment, future advances in molecular-targeted therapy and immunotherapy are also promising. In this Special Issue, we welcome authors to submit papers on the clinical advances of salivary gland lesions in terms of both diagnosis and treatment.

Prof. Dr. Masao Yagi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • salivary gland tumour
  • parotidectomy
  • nerve monitoring
  • molecular-targeted therapy
  • immunotherapy

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Published Papers (3 papers)

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Research

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13 pages, 1014 KiB  
Article
Salivary Gland Tumors in Pregnancy—Treatment Strategies
by Małgorzata Wierzbicka, Katarzyna Radomska, Wioletta Pietruszewska, Dominik Stodulski, Bogusław Mikaszewski, Jarosław Markowski, Paweł Burduk, Aldona Woźniak, Jakub Lubiński and Anna Rzepakowska
J. Clin. Med. 2025, 14(9), 3136; https://doi.org/10.3390/jcm14093136 - 30 Apr 2025
Viewed by 212
Abstract
Background: The management of salivary gland tumors (SGTs) during pregnancy is a subject that has received scant attention in the medical literature. While treatment recommendations for cancer therapy in pregnancy have been delineated, those for benign tumors remain unspecified. The present inquiry [...] Read more.
Background: The management of salivary gland tumors (SGTs) during pregnancy is a subject that has received scant attention in the medical literature. While treatment recommendations for cancer therapy in pregnancy have been delineated, those for benign tumors remain unspecified. The present inquiry focuses on the number of women of reproductive age with SGTs and the optimal diagnostic and treatment strategies for tumors occurring during pregnancy. Materials and Methods: This was a retrospective multicenter cohort study based on data from the Polish Salivary Network Database, collected between 2018 and 2022. From a total of 2653 patients with salivary gland tumors (SGTs), we identified 1313 women, including 300 of reproductive age (16–42 years). Among them, six cases of SGTs diagnosed during pregnancy were included for detailed analysis. Ethical approval was obtained for this study. Results: Among the 300 women of reproductive age, 285 had benign SGTs and 15 had malignant SGTs. Six tumors were diagnosed during pregnancy: four benign (pleomorphic adenomas) and two malignant (salivary duct carcinoma and mucoepidermoid carcinoma). All benign tumors were monitored during pregnancy and surgically treated postpartum. One malignant tumor was resected postpartum, while the second showed a rapid progression in late pregnancy and required early intervention. Individual case details highlighted the diagnostic and therapeutic complexity in this population. Conclusions: A standard diagnostic protocol, incorporating ultrasounds and a fine-needle aspiration biopsy, is recommended during pregnancy. For cases in which the clinical and imaging characteristics suggest a benign origin, surveillance is proposed. Conversely, surgical resection is recommended for malignant SGTs, irrespective of the gestational stage. The potential for the malignant transformation of benign tumors during pregnancy in young women underscores the necessity for surgical intervention prior to planned conception. Full article
(This article belongs to the Special Issue Clinical Management of Salivary Gland Disorders)
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20 pages, 1081 KiB  
Article
Minimally Invasive Interventions in Obstructive and Inflammatory Salivary Gland Diseases: Local Anesthesia Based Pain Management, Stratification of Invasiveness, and Patients’ Perceptions
by Mirco Schapher, Maximilian Traxdorf, Heinrich Iro and Michael Koch
J. Clin. Med. 2025, 14(6), 1797; https://doi.org/10.3390/jcm14061797 - 7 Mar 2025
Viewed by 431
Abstract
Objectives: Since the peri- and intraoperative management of patients with inflammatory and obstructive sialadenitis (IOS) differs significantly between treating centers worldwide, we investigated whether these patients can be treated successfully, resource-savingly and with high patient satisfaction using minimally invasive procedures under local anesthesia [...] Read more.
Objectives: Since the peri- and intraoperative management of patients with inflammatory and obstructive sialadenitis (IOS) differs significantly between treating centers worldwide, we investigated whether these patients can be treated successfully, resource-savingly and with high patient satisfaction using minimally invasive procedures under local anesthesia (LA). Methods: We developed a comprehensive, stratified routine anesthesia and pain management protocol based on our proposed classification of invasiveness (grade 1–4), for almost all available IOS treatment procedures. We included 377 patients with 470 LA-conducted interventions in our study and evaluated their perceptions during and after the treatment. Results: The protocol was applied to all 377 study participants for all 470 interventions. The mean grade of invasiveness was 2.49 ± 1.31, with a mean procedure duration of 30 ± 20 min. We found a significant positive association between invasiveness levels and procedure duration (p = 0.001) or pain directly after surgery (p = 0.004). Patients rated the procedures as ”well acceptable” or better in a large majority (88.1–97%) regarding the administration and potency of LA, procedure duration, and pain during and directly after surgery. In total, 96.4% of patients would have the treatment repeated under the same conditions. Conclusions: The proposed anesthesia and pain management regimen, respecting invasiveness levels, enables IOS patients to undergo treatment under LA with high success rates, serving as a potential guide for performing physicians. Full article
(This article belongs to the Special Issue Clinical Management of Salivary Gland Disorders)
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Review

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20 pages, 1623 KiB  
Review
Significance of Notch Signaling in Salivary Gland Development and Diseases
by Margherita Sisto and Sabrina Lisi
J. Clin. Med. 2025, 14(10), 3325; https://doi.org/10.3390/jcm14103325 - 10 May 2025
Viewed by 203
Abstract
Notch-mediated signaling pathways represent a system that is conserved from an evolutionary point of view, demonstrating a key role in determining cell fate in development; in fact, Notch operates at multiple levels during tissue and organ organization, intervening in the key processes of [...] Read more.
Notch-mediated signaling pathways represent a system that is conserved from an evolutionary point of view, demonstrating a key role in determining cell fate in development; in fact, Notch operates at multiple levels during tissue and organ organization, intervening in the key processes of organogenesis. As a consequence of this, a dysregulation of the Notch-mediated pathways leads to the onset of various pathological conditions such as autoimmune diseases or tumors. The activation of Notch-mediated molecular pathways has also been demonstrated in the development of salivary glands (SGs) and in associated pathologies. Although the numerous advances made in recent years have clarified various aspects of the activation of transductional cascades involving Notch in SGs development and diseases, there are still many aspects that require experimental investigation. In this review, we report, for therapeutic purposes, what is present in the literature relating to the mechanisms regulating the development of Notch-mediated SGs and the most recent discoveries relating to SGs pathologies that derive from alterations of the Notch-mediated pathways. Full article
(This article belongs to the Special Issue Clinical Management of Salivary Gland Disorders)
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