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Innovations in Functional Biomaterials for Biomedical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 869

Editor

School of Dentistry, University of Michigan, Ann Arbor, MI, USA
Interests: hydrogels; bioadhesives; nanocomposites; 3D printing; tissue engineering; hemostasis; biosensing; drug delivery

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the design, development, and application of functional biomaterials that address current challenges in drug delivery, tissue engineering, regenerative medicine, wound healing, and biosensing.

We welcome original research articles and reviews that explore the molecular-level mechanisms underlying biomaterial performance and biological interactions. As IJMS is a journal centered on molecular science, all submissions must include molecular data or insights. This can include, but is not limited to, the characterization of chemical structures, biomolecular interactions, molecular modeling, or analysis of gene- and protein-level responses in biological systems.

This Special Issue aims to bring together interdisciplinary research at the interface of materials science, chemistry, biology, and medicine to highlight how molecular design and understanding can advance biomaterials for clinical applications. We encourage contributions that not only demonstrate innovative material functionality but also provide mechanistic insights at the molecular level.

Dr. Arpita Roy
Guest Editor

Manuscript Submission Information

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Keywords

  • functional biomaterials
  • molecular mechanisms
  • drug delivery systems
  • tissue engineering
  • biointerface interactions
  • smart/stimuli-responsive materials
  • molecular modeling and simulation
  • gene and protein expression
  • biomolecular characterization
  • regenerative medicine

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Published Papers (1 paper)

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Research

21 pages, 11130 KB  
Article
Electrospun Carbothane-Based Drug-Enriched Scaffolds for Cardiovascular Devices: Drug Release, Hemocompatibility, Endothelialization, and Immunological Characterization
by Zhanna K. Nazarkina, Boris P. Chelobanov, Alena O. Stepanova, Aznaur Imenov and Pavel P. Laktionov
Int. J. Mol. Sci. 2026, 27(11), 5081; https://doi.org/10.3390/ijms27115081 - 4 Jun 2026
Viewed by 459
Abstract
Polyurethane (PU) is widely used in medical products due to its biocompatibility and mechanical properties. Electrospinning (ES) was employed to produce PU-based scaffolds intended for cardiovascular devices (CVD) from blends of Carbothane (Carb) with human serum albumin (HSA), dimethylacetamide (DMA), and drugs. Sirolimus [...] Read more.
Polyurethane (PU) is widely used in medical products due to its biocompatibility and mechanical properties. Electrospinning (ES) was employed to produce PU-based scaffolds intended for cardiovascular devices (CVD) from blends of Carbothane (Carb) with human serum albumin (HSA), dimethylacetamide (DMA), and drugs. Sirolimus (SRL)—an immunosuppressive/anti-proliferative drug—and diclofenac (DF)—a nonsteroidal anti-inflammatory drug—were introduced into ES blends to produce drug-enriched scaffolds that prevent inflammation and cell overgrowth. The biocompatibility, stability, and mechanical properties of the scaffolds and SRL release were studied. The scaffolds possessed good mechanical properties and were stable in PBS and blood plasma (BP) for 120 days. The minimal SRL release rate was observed for the scaffold 3%Carb/10%HSA/DMA/SRL. A study of scaffold interaction with blood demonstrated good hemocompatibility of most scaffolds. A study of human gingival fibroblasts, endothelial cells (HUVEC and EA.hy926), and vascular smooth muscle cell interaction with scaffolds in vitro demonstrated variability in cell viability and pro-inflammatory interleukin IL-6 secretion, depending on both the scaffold composition and the cell type. The incorporation of DF into scaffolds decreased the concentration of IL-6 in the culture medium. The scaffold 3%Carb/10%HSA/DMA/SRL is the best choice for CVD in terms of hemocompatibility, endothelialization, and the induction of minimal inflammation. Full article
(This article belongs to the Special Issue Innovations in Functional Biomaterials for Biomedical Applications)
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