Molecular Advance in Nutraceutical Research: From Bioactive Discovery to Translational Application
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 27 April 2026 | Viewed by 21
Special Issue Editor
2. Italian Society of Nutraceutical Formulators (SIFNut), 31033 Treviso, Italy
Interests: bioactive compounds; nutraceuticals; molecular mechanisms; nutraceutical formulations
Special Issue Information
Dear Colleagues,
The scientific advancement of nutraceuticals has shifted from empirical use of botanicals and functional foods to a rigorous, multidisciplinary approach grounded in molecular biology, pharmacology, and translational medicine. The identification of bioactive compounds with targeted health effects now relies on high-throughput screening, metabolomics, proteomics, and in silico modelling, enabling a deeper understanding of their interactions with cellular signalling pathways, receptors, enzymes, and epigenetic regulators.
This Special Issue aims to explore the full pipeline of nutraceutical innovation, from the discovery and molecular characterization of natural bioactives to advanced formulation technologies and validation in preclinical and clinical settings. Emphasis will be placed on studies unravelling mechanistic pathways, bioavailability-enhancing strategies, and the integration of nutraceuticals into personalized medicine frameworks. Investigations of synergistic combinations, structure–activity relationships, and predictive biomarkers of efficacy or safety are also encouraged.
We welcome original research and review articles covering a wide range of compounds polyphenols, alkaloids, peptides, postbiotics, or novel phytochemicals, highlighting its molecular targets and translational potential. Submissions addressing regulatory aspects and challenges in standardization, formulation reproducibility, and evidence-based clinical development are also within the scope of this Special Issue.
Dr. Alessandro Colletti
Guest Editor
Manuscript Submission Information
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Keywords
- bioactive compounds
- nutraceuticals
- molecular mechanisms
- nutraceutical formulations
- preclinical and clinical validation
- targeted delivery systems
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