ijms-logo

Journal Browser

Journal Browser

Molecular Insights into Toxicity: Identifying Biomarkers and Molecular Pathways Involved in Toxicological Responses

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 29 April 2026 | Viewed by 1924

Special Issue Editor


E-Mail Website
Guest Editor
Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Tepic, Nayarit, Mexico
Interests: biomarkers; molecular biology; toxicology; gene expression; environmental exposure

Special Issue Information

Dear Colleagues,

Recent advances in molecular biology, chemistry, and omics technologies have significantly enhanced our understanding of the mechanisms driving toxicity and disease development. Biomarkers have become essential tools for the early detection of adverse effects, monitoring of disease progression, and assessment of environmental and occupational exposures. These molecular indicators serve as crucial links between chemical exposure and health outcomes in both humans and wildlife, playing a central role in toxicology and molecular medicine. In light of increasing concerns regarding the effects of pollutants—such as pesticides, heavy metals, and emerging contaminants—on public and environmental health, there is an urgent need to identify novel biomarkers and to elucidate the molecular pathways involved in toxicological responses.

This Special Issue is supervised by Prof. Dr. Irma Martha Medina Díaz and assisted by Dr. José Francisco Herrera Moreno and Dr. Gabriela María Ávila Villareal (Universidad Autónoma de Nayarit). It aims to provide a platform for high-quality original research, reviews, short communications, perspectives, and other contributions focused on the discovery, validation, and application of biomarkers in toxicological settings. We particularly welcome interdisciplinary studies that integrate molecular biology, chemistry, toxicology, and systems biology to address health risks associated with chemical and environmental exposures. Topics of interest include, but are not limited to, mechanistic toxicology, biomarker development for human and ecological health, exposure assessment, oxidative stress, inflammation, epigenetic and transcriptomic responses, as well as advances in in vitro and in vivo models. By bridging the fields of human and environmental health, this Special Issue seeks to promote scientific dialogue that supports evidence-based risk assessment and informs public health and regulatory policy.

Prof. Dr. Irma Martha Medina Díaz
Guest Editor

Dr. José Francisco Herrera Moreno
Dr. Gabriela María Ávila Villareal
Guest Editor Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • molecular pathways
  • chemical exposure assessment
  • environmental exposure
  • human health
  • public health toxicology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 5626 KB  
Article
Calcitriol Induces Paraoxonase 1 Expression in HepG2 Cells: Possible Involvement of VDR-Dependent and Alternative Pathways
by Fidel Navarro-García, Aurora E. Rojas-García, Gabriela Ávila-Villarreal, Sergio Hidalgo-Figueroa, Briscia S. Barrón-Vivanco, Cyndia A. González-Arias, Yael Y. Bernal-Hernández, José F. Herrera-Moreno, Guillermo Elizondo, José L. Medina-Franco and Irma M. Medina-Díaz
Int. J. Mol. Sci. 2025, 26(16), 7948; https://doi.org/10.3390/ijms26167948 - 18 Aug 2025
Viewed by 1490
Abstract
Paraoxonase 1 (PON1) is an antioxidant enzyme that plays physio-pathological roles. Prior in silico analysis revealed the presence of response elements of the nuclear receptor superfamily in the PON1 promoter, comparable to glucocorticoid receptors (GR), the vitamin D receptor (VDR), and the pregnenolone [...] Read more.
Paraoxonase 1 (PON1) is an antioxidant enzyme that plays physio-pathological roles. Prior in silico analysis revealed the presence of response elements of the nuclear receptor superfamily in the PON1 promoter, comparable to glucocorticoid receptors (GR), the vitamin D receptor (VDR), and the pregnenolone X receptor (PXR). The aim of this study was to evaluate the effects of 1α,25-dihydroxyvitamin D3, a ligand specific to VDR, on the expression and activity of PON1 in hepatocarcinoma cells (HepG2 cells). PON1 activities (arylesterase/AREase and lactonase/LACase) were determined by spectrophotometry. Quantitative real-time PCR was used to evaluate the effect of VDR and PXR on the mRNA levels of PON1 and CYP3A4 genes. Molecular models and dynamics simulations were built using specialized software. Treatments with 1α,25-dyhydroxyvitamin D3 (calcitriol), its active hormonal form, resulted in an induction of PON1 mRNA and AREase activity compared to control cultures. These results suggest that calcitriol plays a role in the regulation of PON1 transcription and provide evidence that this hormone increases PON1 levels in HepG2 cells. In addition, the molecular modeling suggests that calcitriol enhances PON1 activity and this increase could be caused by direct interaction on the PON1 protein. This study shows the effects of calcitriol on PON1 expression, proposing a new molecular mechanism for the transcriptional regulation of PON1 through a process linked to VDR activation and direct interaction of calcitriol on the PON1 protein. Full article
Show Figures

Figure 1

Back to TopTop