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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Locus Coeruleus in Regulating Sudden Cortical States and Preventing Neurodegeneration

edited by

Francesco Fornai

submission deadline 20 Feb 2026 | Viewed by 137 | Submission Open

Keywords: reticular formation; norepinephrine; neuroplasticity; neuroprotection; neurodegenerations; adrenergic receptors; dementia; parkinson's disease; autism; affective disorders; addiction; psychostimulants

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Biomodelling

edited by

Jacques Demongeot

submission deadline 20 Feb 2026 | Viewed by 134 | Submission Open

Keywords: biomodelling; biomathematics; bioinformatics; biostatistics; biophysics; theoretical biology; theoretical ecology; mathematical biology; theoretical physics; physical chemistry

(This special issue belongs to the Section Molecular Informatics)

New Advances in Natural Product Synthesis and Emerging Biotechnology Applications

edited by Katarzyna Kotwica-Mojzych

submission deadline 20 Feb 2026 | Viewed by 134 | Submission Open

Keywords: natural compounds; natural product synthesis; chemical analysis; molecular technologies; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience

edited by Matteo Di Segni and Rossella Ventura

submission deadline 20 Feb 2026 | Viewed by 133 | Submission Open

Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness

(This special issue belongs to the Section Molecular Neurobiology)

The Toxicity of Bisphenol A and Its Analogs

edited by

Krystyna Makowska

submission deadline 20 Feb 2026 | Viewed by 133 | Submission Open

Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology

(This special issue belongs to the Section Molecular Toxicology)

Electron or Ion Transport in Electrochemistry

edited by Simone Sanna

submission deadline 20 Feb 2026 | Viewed by 132 | Submission Open

Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications

edited by Maria Rosaria Tumolo and Saverio Sabina

submission deadline 20 Feb 2026 | Viewed by 130 | Submission Open

Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches

(This special issue belongs to the Section Molecular Informatics)

Natural Compounds in Cancer: Targeting Immune Cells and Signalling Pathways

edited by

Tomasz Jędrzejewski

submission deadline 20 Feb 2026 | Viewed by 129 | Submission Open

Keywords: natural compounds; cancer; inflammation; signalling pathways; antineoplastic agents; macrophage; T cells; molecular mechanism of pharmacological action; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular and Histological Approaches in Oral Tissue Regeneration and Diagnostics

edited by

Fabiana Nicita

submission deadline 20 Feb 2026 | Viewed by 129 | Submission Open

Keywords: dentistry; histological analysis; immunofluorescence; molecular pathogenesis; tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges

edited by

David Rodríguez-Lucena

and

Belén Begines

submission deadline 20 Feb 2026 | Viewed by 127 | Submission Open

Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy

(This special issue belongs to the Section Materials Science)

Contribution of Astrocytes and Microglia for the Development of Neurological Disorders

edited by Rommy Von Bernhardi

submission deadline 20 Feb 2026 | Viewed by 122 | Submission Open

Keywords: aging; astrocytes; glial cells; microglia; neurodegenerative diseases; neuron-glia interaction; neuroimmune response; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment

edited by

Foteinos-Ioannis Dimitrakopoulos

submission deadline 20 Feb 2026 | Viewed by 121 | Submission Open

Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment

(This special issue belongs to the Section Molecular Oncology)

NURR1 Biology in Neurological Disorders and Other Diseases

edited by

Ángel Juan García-Yagüe

submission deadline 20 Feb 2026 | Viewed by 119 | Submission Open

Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases

(This special issue belongs to the Section Molecular Biology)

Acute Myeloid Leukemia: From Molecular Insights to Therapeutic Innovations

edited by

Lukasz Szymanski

submission deadline 20 Feb 2026 | Viewed by 118 | Submission Open

Keywords: acute myeloid leukemia; AML; epigenetic Mechanisms; genetics; epigenetic regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cancer Progression and Therapeutic Resistance Mechanisms

edited by

Fabrizio Fontana

submission deadline 20 Feb 2026 | Viewed by 116 | Submission Open

Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds

(This special issue belongs to the Section Molecular Oncology)

Pain: From Bench to Bedside

edited by

Christopher Robinson

and Robert J. Yong

submission deadline 20 Feb 2026 | Viewed by 114 | Submission Open

Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicological Impacts of Emerging Contaminants on Aquatic Organisms

edited by

Mohamed Hamed

submission deadline 20 Feb 2026 | Viewed by 113 | Submission Open

Keywords: aquatic toxicology; emerging contaminants; physiology and behavior; oxidative stress; antioxidant biomarkers; immunotoxicity; neuroendocrine toxicity; bioremediation; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms

edited by

Dong-Sung Lee

and Chi-Su Yoon

submission deadline 20 Feb 2026 | Viewed by 111 | Submission Open

Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

From Pathogenic Mechanisms to Therapy in Retinal Diseases

edited by

Nan-Kai Wang

and

Eugene Yu Chuan Kang

submission deadline 20 Feb 2026 | Viewed by 103 | Submission Open

Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Electrochemistry and Emerging Contaminants: Molecular Insights for Innovative Solutions

edited by

Miguel A. Esteso

submission deadline 20 Feb 2026 | Viewed by 102 | Submission Open

Keywords: electrochemistry; chemical reactions; removal; environmental pollution

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets

edited by Uchenna John Unachukwu

submission deadline 20 Feb 2026 | Viewed by 96 | Submission Open

Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Nutrition from Cereal Foods: Molecular Insights into Nutrition, Metabolism and Health Regulation

edited by Genyi Zhang

submission deadline 20 Feb 2026 | Viewed by 95 | Submission Open

Keywords: molecular breeding; cereal crops; bioactive compounds; metabolic syndrome; inflammation; gut health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plasticity in Multiple Sclerosis: From Molecular to System Level, from Adaptation to Maladaptation

edited by Gloria Dalla Costa and Laura Cacciaguerra

submission deadline 20 Feb 2026 | Viewed by 93 | Submission Open

Keywords: multiple sclerosis; neuroplasticity; remyelination; synaptic adaptations

(This special issue belongs to the Section Molecular Neurobiology)

Development and Applications of Biodegradable and Bioactive Materials

edited by

Mercedes Ana Peltzer

submission deadline 20 Feb 2026 | Viewed by 88 | Submission Open

Keywords: biopolymers; bioplastics; sustainability; food packaging; medicine and cosmetic; bioactive compounds; wound healing; active and intelligent packaging

(This special issue belongs to the Section Materials Science)

The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development

edited by Gabriela Verónica Salamone

submission deadline 20 Feb 2026 | Viewed by 85 | Submission Open

Keywords: gliomas tumor microenvironment immune

(This special issue belongs to the Section Molecular Oncology)

Advancements in the Electrochemical Detection of Biomolecules: From Sensing to Environmental Applications

edited by

Habibulla Imran

submission deadline 20 Feb 2026 | Viewed by 63 | Submission Open

Keywords: biomolecules; nanomaterials; biorecognition; biomolecular detection; electrochemical

(This special issue belongs to the Section Molecular Biophysics)

Biosensors: Emerging Technologies and Real-Time Monitoring

edited by

Velmurugan Thavasi

submission deadline 20 Feb 2026 | Viewed by 54 | Submission Open

Keywords: biosensors; real-time monitoring; wearable sensors; electrochemical detection; optical biosensors; point-of-care (POC) diagnostics; biomarker identification and analysis; wireless technologies

(This special issue belongs to the Section Biochemistry)

Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions: 2nd Edition

edited by Vija Lavinia

submission deadline 20 Feb 2026 | Viewed by 36 | Submission Open

Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Transcriptional Regulation and Its Misregulation in Human Diseases: Recent Insights

edited by

Amelia Casamassimi

and

Monica Rienzo

submission deadline 20 Feb 2026 | Viewed by 22 | Submission Open

Keywords: transcription machinery; transcription (co)factors; chromatin regulators; splicing regulators; noncoding RNAs; transcription misregulation; genetic alterations; human diseases; transcriptome profiling; bioinformatics analysis

(This special issue belongs to the Section Molecular Biology)

AIEgens in Action: Design, Mechanisms, and Emerging Applications

edited by

Arkadiusz Matwijczuk

submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open

Keywords: fluorescence effects; photophysical properties of small molecules; ion detection; molecular spectroscopy; various nanoparticle-based additives; fluorescent and phosphorescent phenomena in solvents; amorphous states; and crystals; quantum-mechanical calculations for molecular systems and compositions (DFT; TD-DFT); molecular aggregation influencing fluorescence and phosphorescence properties of tested systems

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Advances in Gestational Diabetes Mellitus: 2nd Edition

edited by Natasha Singh

submission deadline 20 Feb 2026 | Viewed by 19 | Submission Open

Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Vector-Mediated Genome Editing Therapy

edited by

Izumu Saito

submission deadline 20 Feb 2026 | Viewed by 16 | Submission Open

Keywords: genome editing; adenovirus vector; knock-in; inherited disease; viral vectors

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unraveling Synaptic Structure and Function in the Healthy and Diseased Brain

edited by

Jacopo Meldolesi

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: molecular studies; axons; synapses; diseases; glial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms in Biofilm Formation, Tolerance and Control: 3rd Edition

edited by

Manuel Simões

and Lúcia Chaves Simões

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: adhesion; antimicrobial action; antimicrobial resistance; biofilm development; biofilm matrix; biofilm structure; quorum sensing; motility; surfaces

(This special issue belongs to the Section Molecular Microbiology)

Decoding Protein Structure and Protein Dynamics in Cancer

edited by

Umesh Kalathiya

and

Monikaben Padariya

submission deadline 20 Feb 2026 | Viewed by 4 | Submission Open

Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Understanding Aging in Health and Disease

edited by

Laura Cianfruglia

submission deadline 25 Feb 2026 | 2 articles | Viewed by 1455 | Submission Open

Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging

(This special issue belongs to the Section Molecular Biology)

Obesity: From Cellular Mechanism to Potential Molecular Therapies

edited by

Veronica Jimenez

submission deadline 25 Feb 2026 | Viewed by 70 | Submission Open

Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Chronic Inflammatory Sinonasal Diseases

edited by Santos Tiago Soares

submission deadline 25 Feb 2026 | Viewed by 38 | Submission Open

Keywords: chronic rhinosinusitis; nasal polyps; type 2 inflammation; sinonasal immunopathology; molecular pathways; host– microbiome interaction; precision medicine; upper airway disease; translational research

(This special issue belongs to the Section Molecular Immunology)

Molecular Pathophysiology and Treatments of Diabetes

edited by

Carlo Acierno

submission deadline 26 Feb 2026 | Viewed by 86 | Submission Open

Keywords: diabetes mellitus; molecular pathophysiology; insulin resistance; beta-cell dysfunction; chronic inflammation; epigenetics; metabolic syndrome; SGLT2 inhibitors; GLP-1 receptor agonists; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Prospects in Neurons

edited by

Tam Thanh Quach

submission deadline 27 Feb 2026 | Viewed by 5 | Submission Open

Keywords: DNA damage/repair; genetic/epigenetic; 3D genomic; global transcriptome analysis; transgenic animals; neuron polarization/genesis/network; neuro-developmental/psychiatric diseases; brain structures; intelligence/intellectual disability

(This special issue belongs to the Section Molecular Neurobiology)

Drug Discovery Based on Natural Products

edited by Woo-kyung Kim

submission deadline 28 Feb 2026 | 5 articles | Viewed by 7706 | Submission Open

Keywords: drug discovery; bioactive compounds; pharmacological activities and mechanisms; omics technologies

(This special issue belongs to the Section Molecular Pharmacology)

New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms

edited by

Laura Georgiana Necula

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1098 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostic; targeted therapy; biomarkers; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Trends and Future Directions in Antimicrobial Peptide Research

edited by

Sara Elsa Aita

submission deadline 28 Feb 2026 | 1 articles | Viewed by 393 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance

(This special issue belongs to the Section Molecular Biology)

Oral Diseases: Molecular Research and Novel Therapy

edited by

I-Ta Lee

submission deadline 28 Feb 2026 | Viewed by 251 | Submission Open

Keywords: oral diseases; molecular mechanisms; inflammation and immunity; redox signalling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions

edited by

Andrius Sakalauskas

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis

(This special issue belongs to the Section Molecular Neurobiology)

Strategies for Enhancing Skeletal Muscle Recovery and Regeneration in Health and Disease Conditions

edited by

Elen Miyabara

and

Atsushi Asakura

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: skeletal muscle; regeneration; muscle wasting; aging; muscle diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Extracellular Vesicles in Immune Regulation

edited by Rachel Crossland

submission deadline 28 Feb 2026 | Viewed by 61 | Submission Open

Keywords: extracellular vesicle; immune regulation; immunomodulation; antigen presentation; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition

edited by

Tao Sun

and

Xujin Bao

submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open

Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis

(This special issue belongs to the Section Materials Science)

Dermatological Perspectives on Connective Tissue Diseases

edited by Yoshihide Asano

submission deadline 28 Feb 2026 | Viewed by 44 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Alcohol Use Disorder: From Molecular Mechanisms to Therapeutics

edited by

Giampiero Ferraguti

submission deadline 28 Feb 2026 | Viewed by 34 | Submission Open

Keywords: alcohol; addiction; FASD; alcohol-related damage

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3101-3150 on page 63 of 67.

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