Molecular Research in Chronic Inflammatory Sinonasal Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 4
Special Issue Editor
Interests: chronic rhinosinusitis; type 2 inflammation; nasal polyps; sinonasal immunopathology; endoscopic sinus surgery; olfactory dysfunction
Special Issue Information
Dear Colleagues,
Chronic inflammatory sinonasal diseases, including chronic rhinosinusitis with and without nasal polyps, represent a significant health burden due to their chronicity, recurrence, and impact on quality of life. The past decade has seen advances in molecular biology that have assisted in elucidating the mechanisms of these conditions, demonstrating various endotypes and complex inflammatory networks. This Special Issue aims at bringing together high-quality research exploring the molecular mechanisms of sinonasal inflammation, including epithelial barrier function, immune signaling pathways, host–microbiome interactions, tissue remodeling, and type 2 inflammation. We particularly welcome research focusing on biomarkers for diagnosis and treatment response, molecular effects of biologic therapies, mechanisms of corticosteroid resistance, and translational models connecting basic science to the clinic. Review articles that outline recent progress and identify gaps in knowledge are also accepted. We think that this collection will stimulate scientific discussion and, ultimately, aid in the development of precision medicine approaches to rhinology.
Dr. Santos Tiago Soares
Guest Editor
Manuscript Submission Information
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Keywords
- chronic rhinosinusitis
- nasal polyps
- type 2 inflammation
- sinonasal immunopathology
- molecular pathways
- host–microbiome interaction
- precision medicine
- upper airway disease
- translational research
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