Molecular Pathophysiology and Treatments of Diabetes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 26 February 2026 | Viewed by 23
Special Issue Editor
Interests: metabolic syndrome; multidrug-resistant infections; antimicrobial resistance; im-munometabolism; gut microbiota; insulin resistance; dysbiosis; host–pathogen interaction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetes mellitus is a multifactorial and heterogeneous metabolic disorder characterized by chronic hyperglycemia and associated with a wide range of systemic complications. Recent research has increasingly focused on the molecular underpinnings of disease onset and progression, with emphasis on oxidative stress, mitochondrial dysfunction, altered signaling pathways (e.g., PI3K/AKT, AMPK), chronic inflammation, and epigenetic modifications. This Special Issue aims to bring together cutting-edge contributions that elucidate the molecular pathophysiology of both type 1 and type 2 diabetes, including mechanisms of insulin resistance, beta-cell dysfunction, and metabolic inflexibility. Moreover, we encourage submissions addressing emerging therapeutic strategies targeting molecular pathways, such as GLP-1 receptor agonists, SGLT2 inhibitors, and agents modulating the gut microbiota, immunometabolism, or lipidomic profiles. Studies employing advanced molecular techniques (e.g., omics approaches, molecular imaging, CRISPR gene editing) are particularly welcome. Both original research articles and comprehensive reviews are invited. The ultimate goal is to provide an updated, integrative overview of how molecular insights can inform personalized and effective treatment paradigms for diabetic patients.
Dr. Carlo Acierno
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetes mellitus
- molecular pathophysiology
- insulin resistance
- beta-cell dysfunction
- chronic inflammation
- epigenetics
- metabolic syndrome
- SGLT2 inhibitors
- GLP-1 receptor agonists
- gut microbiota
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