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Molecular Insights into Skin Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 June 2026) | Viewed by 1016

Editor


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Guest Editor
Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy
Interests: non-melanoma skin cancer; melanoma; photodynamic therapy (PDT); inflammatory diseases; dermoscopy; dermatology imaging; actinic keratosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our upcoming Special Issue on “Molecular Insights into Skin Health and Disease”. This Special Issue aims to highlight recent advances in our understanding of the molecular and immunological basis of both skin physiology and pathology.

Potential topics of interest include, but are not limited to, the molecular mechanisms that maintain skin homeostasis, the identification of disease-associated biomarkers, the characterization of dysregulated signaling pathways, and the discovery of novel therapeutic targets in inflammatory, autoimmune, infectious, and neoplastic skin diseases.

We particularly encourage submissions exploring the mechanisms of action and clinical relevance of targeted therapies, such as JAK inhibitors, monoclonal antibodies, and RNA-based strategies.

We welcome original research articles and comprehensive reviews that provide new insights into the molecular basis of skin health and disease and contribute to the advancement of precision dermatology. We look forward to hearing from you.

Dr. Federica Li Pomi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatology
  • molecular mechanisms
  • targeted therapy
  • biomarkers

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Published Papers (1 paper)

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Review

29 pages, 3251 KB  
Review
Beyond Inflammation: The Role of Oxidative Stress and Gut–Skin Axis Dysbiosis in the Pathogenesis of Immune-Mediated Skin Disorders and Potential Therapeutic Implications
by Maria Clara Gama de Souza Silva, Lucrezia De Pietro, Carla Ruffino San Cataldo, Antonio Bisaccia, Federica Nuccio, Federica Li Pomi and Sebastiano Gangemi
Int. J. Mol. Sci. 2026, 27(11), 4656; https://doi.org/10.3390/ijms27114656 - 22 May 2026
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Abstract
The skin is a complex immunological organ in which reactive oxygen species (ROS)-related pathways and host–microbe interactions synergically maintain immune homeostasis. Dysregulation of several oxidative mechanisms, including lipid peroxidation, mitochondrial dysfunction, ferroptosis, and impaired antioxidant defenses, alongside gut microbiome imbalance, is increasingly recognized [...] Read more.
The skin is a complex immunological organ in which reactive oxygen species (ROS)-related pathways and host–microbe interactions synergically maintain immune homeostasis. Dysregulation of several oxidative mechanisms, including lipid peroxidation, mitochondrial dysfunction, ferroptosis, and impaired antioxidant defenses, alongside gut microbiome imbalance, is increasingly recognized as a key modulator of the immune response involved in disease onset and progression. However, their role in immune-mediated dermatoses remains incompletely defined. This narrative review aims to provide a comprehensive overview of the contribution of these altered pathways to the pathogenesis and prognosis of the major immune-mediated skin diseases. Across all conditions examined, elevated oxidative biomarkers, such as malondialdehyde (MDA), advanced glycation end-products (AGEs), advanced oxidation protein products (AOPPs), 8-hydroxydeoxyguanosine (8-OHdG), and reduced antioxidant capacity are consistently reported. Ferroptosis, driven by iron-dependent lipid peroxidation and dysfunction of Glutathione peroxidase 4 (GPX4), emerges as a relevant cell death pathway, particularly in psoriasis and atopic dermatitis (AD). In parallel, dysbiosis of the gut and skin microbiomes, characterized by depletion of short-chain fatty acid (SCFA)-producing taxa such as Faecalibacterium prausnitzii, Bifidobacterium, and Akkermansia muciniphila, has been reported across multiple diseases. Particular attention is given to shared molecular axes, such as the disruption of epithelial barrier integrity, activation of innate and adaptive immune responses, and the role of microbial-derived metabolites in modulating redox signaling, unraveling a bidirectional crosstalk. Emerging therapeutic strategies targeting these bidirectional crosstalks show biological plausibility and promising preliminary results. Integrating redox and microbial profiling into clinical practice may improve patient stratification and foster the development of more personalized therapeutic approaches beyond conventional immunological treatments. Full article
(This article belongs to the Special Issue Molecular Insights into Skin Health and Disease)
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