The Role of Iron in Human Physiology: Molecular Mechanisms and Therapeutic Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 59
Special Issue Editor
Interests: biomarkers; neurodegenerative disease; iron pathophysiology; mitochondrial disease; transplant allograft function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Iron status influences a vast array of cellular processes. Iron imbalance or dysregulation can have adverse, clinically significant effects on gene regulation, enzyme activities, mitochondrial function, stress response, and even cell viability. Absolute or functional iron deficiency can lead to morbidity, impairs neurobehavioural development in early life, predisposes to immune dysfunction, and is associated with adverse outcomes in patients with cancer, heart failure, or those undergoing surgery. At the other end of the spectrum, iron has been associated with inflammatory processes, oxidative stress, mitochondrial dysfunction, and ferroptosis. Some of these mechanisms and related cellular events have implications for neurodegenerative, cardiovascular, pulmonary, hepatic, and other disorders. Expanding knowledge of the involvement of iron in cellular function has encouraged exciting avenues of research that are increasing our understanding of the pathogenic mechanisms of some common diseases, and may pave the way for interventions that would alleviate these conditions or improve clinical outcomes.
I am pleased to invite researchers who are studying cellular and molecular processes and mechanisms of disease that involve iron to submit their original research or review articles for this Special Issue of the International Journal of Molecular Sciences. The aim of this Special Issue is to disseminate emerging knowledge and overviews of the underlying pathophysiological mechanisms through which iron regulates cellular processes and the way its imbalance may bring about clinical effects. Research involving clinical studies or the use of cells is especially welcome.
Dr. Alireza Morovat
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- iron
- hepcidin
- ferroportin
- ferritin
- transferrin
- metabolic regulation
- cell signaling
- cellular processes
- mitochondrial function
- stress response
- inflammation
- ferroptosis
- gene regulation
- disorders
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
