Advances in the Pathology and Pathogenetic Mechanisms of Diabetic Neuropathy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 210
Editor
Special Issue Information
Dear Colleagues,
Diabetic neuropathy represents one of the most prevalent and debilitating chronic complications of diabetes mellitus, arising from complex and interrelated metabolic, vascular, inflammatory, and neurodegenerative processes. Persistent hyperglycemia triggers oxidative stress, mitochondrial dysfunction, impaired axonal transport, neuroinflammation, and microvascular damage, ultimately leading to progressive structural and functional injury of the peripheral and central nervous systems. Despite its high clinical burden—manifesting as pain, sensory loss, autonomic dysfunction, and increased risk of morbidity—effective disease-modifying therapies remain limited, largely due to incomplete understanding of the underlying pathogenic mechanisms. Advancing knowledge of the molecular and cellular pathways driving diabetic neuropathy is therefore critical for identifying novel biomarkers, therapeutic targets, and personalized treatment strategies. This Special Issue aims to integrate emerging insights from basic, translational, and clinical research to deepen our understanding of the pathology and pathogenesis of diabetic neuropathy and to foster innovation in its diagnosis and management.
The aim of this Special Issue is to provide a focused and cohesive platform for advancing the understanding of the pathological features and pathogenetic mechanisms underlying diabetic neuropathy, spanning molecular, cellular, tissue, and clinical pathology. By emphasizing mechanistic insights, disease models, and translational relevance, this Special Issue aligns closely with the journal’s scope in experimental and clinical pathology, while remaining sufficiently focused to foster a high-impact collection of original research and authoritative reviews that collectively advance the field.
- Cellular and Molecular Mechanisms of Peripheral Nerve Injury in Diabetic Neuropathy
Axonal degeneration, Schwann cell dysfunction, mitochondrial impairment, oxidative stress, and altered energy metabolism. - Neuroinflammation and Neurovascular Pathology
Pathological roles of inflammatory signaling, glial activation, immune–nerve interactions, and microvascular damage. - Structural and Histopathological Changes in Diabetic Neuropathy
Nerve and skin biopsy findings, myelin and axonal pathology, nodal/paranodal alterations, and ultrastructural studies. - Small Fiber and Autonomic Neuropathy: Pathological Correlates
Mechanisms underlying sensory and autonomic dysfunction with emphasis on tissue-level pathology. - Experimental and Translational Models of Diabetic Neuropathy
Pathology-driven insights from animal and cellular models with clear relevance to human disease. - Pathology-Based Biomarkers and Therapeutic Targets
Tissue, molecular, and imaging markers linked to disease progression and mechanism-informed interventions.
Article Types
- Original Research Articles
- Focused Reviews or Mini-Reviews
- Clinical–Pathological Correlation Studies
- Short Communications with strong mechanistic or pathological insight
We look forward to receiving your contributions.
Dr. Aditya K. Singh
Guest Editor
Manuscript Submission Information
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Keywords
- diabetic
- neuroinflammation
- neurovascular pathology
- neuropathy
- nerve injury
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