Stem Cell Innovations and Reproductive Biotechnologies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 December 2025 | Viewed by 16
Special Issue Editor
Interests: reproductive biology and biotechnology in different mammalian and avian species (especially pigs, goats, cattle, rabbits, horses, chickens and ducks); assisted reproductive technologies (ARTs)—experimental and applied embryology; intra- and interspecies somatic cell cloning by somatic cell nuclear transfer (SCNT); transgenic research; parthenogenetic activation of oocytes (methods and molecular mechanisms of oocyte activation); in vitro embryo production (IVP)—in vitro oocyte maturation (IVM), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), in vitro embryo culture (IVC); stem cell research; epigenetic and molecular aspects of somatic/stem cell culture engineering; epigenetics in cell differentiation/dedifferentiation, embryogenesis and developmental biology; epigenetic modulation of nuclear donor cells (somatic cells, stem cells), SCNT-derived oocytes or cloned embryos; unveiling the transcriptomic, proteomic and epigenomic profiles in nuclear donor cell lines (somatic and stem cell lines) and nuclear recipient oocytes; the ART-mediated programs focused on biotechnological, transgenic and biomedical research
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Special Issue Information
Dear Colleagues,
Thus far, miscellaneous types of stem cells have been discovered and thoroughly explored. They are represented, among others, by (1) pluripotent embryonic stem cells (ESCs); (2) multipotent fetal/adult somatic stem cells of mesenchymal or hematopoietic origin (MSCs or HSCs); and (3) induced pluripotent stem cells (iPSCs). Establishing a foundational comprehension of molecular and epigenetic plasticity, which underlies the abilities of all categories of stem cells to self-renew, perpetuate pluri- or multipotency and differentiate into specialized somatic cells, is crucial for uncovering their core transcriptomic, proteomic and epigenomic profiles.
This Special Issue provides the multi-faceted molecular basis for revealing the importance of current and coming trends in stem cell research and its potential implications to not only experimental embryology in mammals and birds, but also advanced reproductive biotechnologies, including SCNT-mediated cloning and IVF in mammals. Stem cell innovations targeted at the elaboration of transgenic or non-transgenic in vitro and in vivo models might be a pivotal stimulus for the rapid development of studies focused on increasing their applicability to medical approaches. The latter encompass specimen-specific reconstructive, regenerative and anti-aging therapies in avian and mammalian species, including humans.
Prof. Dr. Marcin Samiec
Guest Editor
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Keywords
- mammals
- birds
- stem cell research
- pluri-/multipotency
- differentiation/dedifferentiation
- assisted reproductive technologies (ARTs)
- transgenic research
- biomedicine
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