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Molecular Advances in Functional Products for Health Prevention and Promotion

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 533

Special Issue Editor


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Guest Editor
Department of Human Nutrition and Dietetics, University of Agriculture in Krakow, A. Mickiewicz Av. 21, 31-120 Krakow, Poland
Interests: health prevention; human nutrition; nutrigenomics; nutrition and immunity; epigenetics; functional foods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Preventive health and health promotion are the most important factors responsible for the stability of the healthcare system and prolonging life, particularly a healthy life. A key role in this process is played by health-promoting food, especially functional food.

Functional food provides specific health benefits and are often enriched with bioactive ingredients, such as vitamins, minerals, and phytochemicals. The potential of functional food in preventing diseases has been demonstrated through its ability to improve the overall nutritional status of the body and modulate inflammation, among other functions. Bioactive ingredients contained in some functional products can help regulate the immune system and reduce chronic inflammation, the latter of which is associated with the development of many chronic non-communicable diseases. In addition, bioactive ingredients can modify epigenetic marks, such as DNA methylation and histone modification.

In this Special Issue, supervised by Dr. Aneta Koronowicz with the assistance of our Topical Advisory Panel Member Dr. Ewelina Piasna-Słupecka (University of Agriculture in Krakow), we will discuss the following:

  1. The health benefits of functional foods with bioactive ingredients;
  2. Relationships between bioactive ingredients present in the diet and chronic non-communicable diseases;
  3. Functional foods and their epigenetic effects;
  4. New bioactive food ingredients with improved bioavailability and tolerance, used in the prevention of chronic non-communicable diseases.

Importantly, the exact active ingredients in functional foods must be reported in submitted manuscripts; we regret that those describing the effects of mixed substances without ingredient descriptions will not be accepted.

Dr. Aneta Koronowicz
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional foods
  • food fortification
  • biofortification
  • bioactive food ingredients
  • human nutrition
  • nutrition and immunity
  • health prevention
  • chronic non-communicable diseases
  • epigenetics

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Published Papers (1 paper)

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Research

26 pages, 4405 KiB  
Article
Updated Meta-Analysis on Vitamin Supplementation for Chronic Pruritus: Expanding Evidence Beyond Vitamin D
by Wu-Hsien Kuo, Ko-Shih Chang, Mu-Hsin Chang, Yao Hsiao and Ru-Yin Tsai
Int. J. Mol. Sci. 2025, 26(8), 3840; https://doi.org/10.3390/ijms26083840 - 18 Apr 2025
Viewed by 191
Abstract
Chronic pruritus is a distressing condition associated with various dermatological and systemic diseases, significantly impairing patients’ quality of life. While conventional treatments such as antihistamines and corticosteroids offer relief, their efficacy varies, and long-term use may lead to adverse effects. Emerging evidence suggests [...] Read more.
Chronic pruritus is a distressing condition associated with various dermatological and systemic diseases, significantly impairing patients’ quality of life. While conventional treatments such as antihistamines and corticosteroids offer relief, their efficacy varies, and long-term use may lead to adverse effects. Emerging evidence suggests that certain vitamins, including vitamin D, vitamin E, vitamin B12, and niacinamide (B3), may play a role in alleviating pruritus through their anti-inflammatory, immune-regulatory, and skin barrier-enhancing properties. However, the effectiveness of these vitamins in managing chronic pruritus remains unclear. This meta-analysis aims to update and expand the evaluation of vitamin supplementation in reducing pruritus severity across different underlying conditions, extending the scope beyond vitamin D to include vitamins B and E. A comprehensive search was performed across PubMed, Embase, Web of Science, and Cochrane Library databases up to January 2025 to identify randomized controlled trials (RCTs) evaluating the effects of vitamin supplementation on chronic pruritus. A total of 21 RCTs (n = 1723) were included in the meta-analysis. Compared to placebo, vitamin supplementation demonstrated a significant reduction in pruritus severity (Standardized Mean Difference [SMD]: −0.578, 95% CI: −0.736 to −0.419, p = 0.000; I2 = 53.630, p = 0.003). Subgroup analysis revealed that topical vitamin B12 and vitamin D3 showed the most pronounced antipruritic effects, particularly in patients with atopic dermatitis and chronic kidney disease-associated pruritus. Sensitivity analysis confirmed the robustness of the findings; however, potential publication bias was suggested by Egger’s regression test (p = 0.00979), indicating that the overall effect may be influenced by small-study effects or underreporting of negative results. This meta-analysis indicates that vitamin B, D, and E supplementation may serve as effective adjunct therapies for managing chronic pruritus. However, the variability among the included studies highlights the necessity for well-structured, long-term RCTs to determine the ideal dosage, treatment duration, and target patient populations that would derive the greatest benefit from vitamin-based interventions. Full article
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