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Multi-Omics Approaches to Disentangle Pathomechanisms in Neurological Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 845

Special Issue Editors


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Guest Editor
Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, piazzale L. A. Scuro 10, 37134 Verona, Italy
Interests: neurodegeneration; neurobiology; molecular mechanisms; lysosomal storage diseases; in vitro disease models; omics; bioinformatics

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Guest Editor

Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in our Special Issue on “Multi-omics Approaches to Disentangle Pathomechanisms in Neurological Disease”, which is being prepared for the International Journal of Molecular Sciences.

Despite significant advancements in recent years, the comprehension of the molecular mechanisms underlying both inherited and acquired neurological diseases still represents a scientific challenge and requires further efforts to be fully achieved. Undeniably, the employment of omics technologies, and especially their integration into the so-called multi-omics approach, has improved our understanding of the molecular basis of diseases affecting the nervous system. Moreover, the possibility of combining datasets from different omics analyses allows us to identify the biomarkers that are suitable for the monitoring of disease progression and eventually develop innovative therapeutical strategies, including the recognition of new molecular candidates for pharmacological targeting.

The aim of this Special Issue is to collect original research articles and review papers dealing with omics technologies and their applications to the investigation of the pathomechanisms underling human disorders affecting the nervous system. Technical papers describing innovative approaches and computational bioinformatic advancements in this field are also highly welcome.

Dr. Francesco Pezzini
Dr. Stefano Doccini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • neurological diseases
  • molecular mechanisms
  • neurodegeneration
  • omics
  • bioinformatics
  • disease biomarkers
  • biochemical pathways
  • diagnostic and therapeutic targets

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Published Papers (1 paper)

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Research

17 pages, 12102 KiB  
Article
Multiomics Integration of Parkinson’s Disease Datasets Reveals Unexpected Roles of IRE1 in Its Pathology
by Bianka Alexandra Pasat, Matthieu Moncan, Eleftherios Pilalis, Afshin Samali, Aristotelis Chatziioannou and Adrienne M. Gorman
Int. J. Mol. Sci. 2025, 26(14), 6711; https://doi.org/10.3390/ijms26146711 - 12 Jul 2025
Viewed by 251
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disease. It primarily affects the motor system but is also associated with a range of cognitive impairments that can manifest early in disease progression, indicating its multifaceted nature. In this paper, we performed a [...] Read more.
Parkinson’s disease (PD) is the second most common neurodegenerative disease. It primarily affects the motor system but is also associated with a range of cognitive impairments that can manifest early in disease progression, indicating its multifaceted nature. In this paper, we performed a meta-analysis of transcriptomics and proteomics data using MultiOmicsIntegrator to gain insights into the post-transcriptional modifications and deregulated pathways associated with this disease. Our results reveal differential isoform usage between control and PD patient brain samples that result in enriched alternative splicing events, including an extended UTR length, domain loss, and the upregulation of non-coding isoforms. We found that Inositol-Requiring Enzyme 1 (IRE1) is active in PD samples and examined the role of its downstream signaling through X-box binding mRNA 1 (XBP1) and regulated IRE1-dependent decay (RIDD). We identified several RIDD candidates and showed that the enriched alternative splicing events observed are associated with RIDD. Moreover, in vitro mRNA cleavage assays demonstrated that OSBPL3, C16orf74, and SLC6A1 mRNAs are targets of IRE1 RNAse activity. Finally, a pathway enrichment analysis of both XBP1s and RIDD targets in the PD samples uncovered associations with processes such as immune response, oxidative stress, signal transduction, and cell–cell communication that have previously been linked to PD. These findings highlight a potential regulatory role of IRE in PD. Full article
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