New Molecular Insights into Ischemia/Reperfusion: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 245
Special Issue Editor
Interests: ischemia/reperfusion; neurodegeneration; neurogenesis; cerebral ischemia; aging in CNS
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ischemia/reperfusion (IR) causes a complex pathophysiological process, called IR injury, defined as the paradoxical exacerbation of cellular dysfunction and death following the restoration of blood flow to previously ischemic tissues. IR injury happens in a wide range of organs, including the heart, brain, spinal cord, gut, kidney, and skeletal muscle. IR injury not only involves the ischemic organ itself but also induces systemic damage to distant organs. Huge efforts have been made to develop potential treatments for IR injury, but the molecular and cellular mechanisms of IR injury are not fully understood regarding organs. Therefore, many researchers have been investigating the mechanisms of IR injury in diverse organs using various experimental animal models of IR injury (i.e., different methods of the occlusion of blood vessels and different periods of occlusion time). Principally, the mechanisms of IR injury include excitotoxicity, oxidative stress, and inflammation. Nevertheless, the mechanisms are significantly different depending on the organs. For instance, blood–brain (spinal cord) barrier damage is one of the mechanisms of IR injury in the central nervous system. Therefore, investigation into the molecular mechanisms of IR injury in various organs is warranted so that we can treat or protect against IR injury. Thus, this Special Issue will focus ischemia/reperfusion in various organs, including the heart, brain, spinal cord, liver, and kidneys.
Prof. Dr. Moo-Ho Won
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- vital organs
- ischemic injury
- cell and organ dysfunction
- oxidative stress
- inflammation
- excitotoxicity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
