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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biological Barriers: Consciousness and Mental Illness

edited by

Adonis Sfera

submission deadline 31 Aug 2025 | Viewed by 140 | Submission Open

Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases

(This special issue belongs to the Section Molecular Biology)

Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals

edited by

Xiang Ma

and

Pengtao Ma

submission deadline 31 Aug 2025 | Viewed by 140 | Submission Open

Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 31 Aug 2025 | Viewed by 139 | Submission Open

Keywords: genetic diseases; genotype– phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Selected Papers from the 1st RNA and RNase International Meeting and Related Research

edited by

Ester Boix

submission deadline 31 Aug 2025 | Viewed by 137 | Submission Open

Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA binding proteins; RNA recognition patterns; RNA catalysis

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Angiogenesis: Mechanisms, Signaling, and Therapeutic Horizons

edited by Edgar Delgado-Eckert

submission deadline 31 Aug 2025 | Viewed by 132 | Submission Open

Keywords: angiogenesis; VEGF; intracellular signaling in vascular biology; anti-angiogenic therapy for cancer; artery disease; age-related macular degeneration

(This special issue belongs to the Section Molecular Biology)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 31 Aug 2025 | Viewed by 132 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell– cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Exploring Molecular Mechanism in Infertility

edited by

Antonio Simone Laganà

and Andrea Etrusco

submission deadline 31 Aug 2025 | Viewed by 124 | Submission Open

Keywords: infertility; molecular mechanisms; reproductive biology; genomics; epigenetics; biomarkers; assisted reproductive technologies; transcriptomics; proteomics; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 31 Aug 2025 | Viewed by 123 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms

edited by

Laura Georgiana Necula

submission deadline 31 Aug 2025 | Viewed by 122 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostic; targeted therapy; biomarkers; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiome-Immunity Crosstalk and Its Role in Health and Disease

edited by

Ana Isabel Beltrán-Velasco

and Sara Uceda

submission deadline 31 Aug 2025 | Viewed by 121 | Submission Open

Keywords: gut microbiota; immune system; nutrition; inflammatory processes; dysbiosis; neurodegenerative diseases

(This special issue belongs to the Section Molecular Microbiology)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 31 Aug 2025 | Viewed by 118 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biotransformation and Engineering of Fungals and Microalgae

edited by Alejandro Chamizo-Ampudia

submission deadline 31 Aug 2025 | Viewed by 118 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 31 Aug 2025 | Viewed by 115 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Insights into Lymphoid Organ Development, Regulation and Therapeutic Potential

edited by Hélia Neves

submission deadline 31 Aug 2025 | Viewed by 114 | Submission Open

Keywords: thymus; immune; signaling; molecular; pathways; epigenetics; organoids; bioengineering; regeneration; clinical application

(This special issue belongs to the Section Molecular Biology)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 31 Aug 2025 | Viewed by 112 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Wearable Self Diagnostics: Against Microbiology Infection

edited by Suw Young Ly

submission deadline 31 Aug 2025 | Viewed by 110 | Submission Open

Keywords: in vivo; in vitro; assay; molecule; skin; AI medical doctor; semiconductor; digital signal; unmanned diagnosis treatment

(This special issue belongs to the Section Molecular Microbiology)

Molecular Targets in Alzheimer’s Disease: From Mechanisms to Therapeutic Strategies

edited by

Mohammad Ejaz Ahmed

submission deadline 31 Aug 2025 | Viewed by 110 | Submission Open

Keywords: amyloid beta; neurodegeneration; neuroinflammation; microglia; mitochondrial dysfucntion; oxidative stress; molecular pathway; biomarkers of AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 31 Aug 2025 | Viewed by 108 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Cardiovascular Research: From Molecular Mechanisms to Novel Therapies

edited by Piotr Musiałek, Monika M. Gladká and Lukasz Tekieli

submission deadline 31 Aug 2025 | Viewed by 106 | Submission Open

Keywords: cardiovascular diseases; cardiovascular repair and regeneration; molecular cardiology; gene and stem cell therapy; drug and gene delivery; advanced imaging; biomarkers; tissue engineering; thrombosis and clotting abnormalities; animal models of human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 31 Aug 2025 | Viewed by 106 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Targeted Therapy of Lymphedema

edited by

Raghu P. Kataru

and Geoffrey E. Hespe

submission deadline 31 Aug 2025 | Viewed by 101 | Submission Open

Keywords: secondary lymphedema; breast cancer related lymphedema; chronic CD4+ T cell inflammtion Th2 driven fribrosis; lymphatic pathophysiology; tissue fibrosis; lymphovenous bypass; lymph node transplanatation; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment

edited by

Marco Fiore

submission deadline 31 Aug 2025 | Viewed by 100 | Submission Open

Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress

(This special issue belongs to the Section Molecular Biology)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 31 Aug 2025 | Viewed by 98 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 31 Aug 2025 | Viewed by 98 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Metabolic Engineering and Synthetic Biology of Yeasts

edited by

Justyna Ruchała

submission deadline 31 Aug 2025 | Viewed by 96 | Submission Open

Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

From Diet to Health: Which Molecules or Chemicals Are at Work?

edited by Sara Baldelli

submission deadline 31 Aug 2025 | Viewed by 96 | Submission Open

Keywords: balanced diet; functional nutrition; nutraceuticals; disease prevention; bioactive biomolecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Cervical Cancer and Its Therapy

edited by Ilaria Cuccu and

Violante Di Donato

submission deadline 31 Aug 2025 | Viewed by 95 | Submission Open

Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes

(This special issue belongs to the Section Molecular Oncology)

Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology

edited by

Elias R. Olivera

submission deadline 31 Aug 2025 | Viewed by 95 | Submission Open

Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits

(This special issue belongs to the Section Molecular Microbiology)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 31 Aug 2025 | Viewed by 94 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Innovative Applications of Topical Probiotics in Dermatology: Addressing Multiple Skin Disorders

edited by

Mireia Mallandrich Miret

submission deadline 31 Aug 2025 | Viewed by 92 | Submission Open

Keywords: topical probiotics in dermatology; skin microbiome; skin disorders; therapeutic applications; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Mechanisms of Receptor Activation

edited by

Zong-Jie Cui

submission deadline 31 Aug 2025 | Viewed by 92 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

Epigenetics and RNA Processing Involved in Disease

edited by

Naoyuki Kataoka

submission deadline 31 Aug 2025 | Viewed by 91 | Submission Open

Keywords: RNA processing; RNA splicing; epigenetics; DNA modification; histone modification; RNA modification; RNA diseases; genetic diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Genetics and Genomics of Ruminants—Second Edition

edited by

Brad A. Freking

submission deadline 31 Aug 2025 | Viewed by 91 | Submission Open

Keywords: ruminant genomics; structural genomics; functional genomics; epigenomics; gene expression; genome sequencing; genome evolution; genome-wide association study; genomic selection; marker-assisted selection

(This special issue belongs to the Section Molecular Genetics and Genomics)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 31 Aug 2025 | Viewed by 91 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Cell Biology and Biochemistry of Gynaecological Cancer: Pathways to Discovering Novel Treatments

edited by

Kenny Chitcholtan

submission deadline 31 Aug 2025 | Viewed by 90 | Submission Open

Keywords: gynaecological cancer; ovarian cancer; endometrial cancer; cervical cancer; cell biology; treatment; cell metastasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: Molecular Diagnosis and Treatment

edited by

Teresa Lettini

submission deadline 31 Aug 2025 | Viewed by 88 | Submission Open

Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way

edited by

Mariano Francesco Caratozzolo

submission deadline 31 Aug 2025 | Viewed by 86 | Submission Open

Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Photobiomodulation Therapy

edited by Maria Fernanda Setúbal Destro Rodrigues

submission deadline 31 Aug 2025 | 1 articles | Viewed by 86 | Submission Open

Keywords: photobiomodulation; dosimetric parameters; human diseases; modulation of inflammation; photobiomodulation therapy; molecular mechanisms; preclinical and clinical studies; therapeutic applications of PBM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Development Biology of Immune Cells

edited by Jacek Z. Kubiak

submission deadline 31 Aug 2025 | Viewed by 85 | Submission Open

Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells

(This special issue belongs to the Section Molecular Immunology)

Pharmacogenomics: The State of the Art and Future Perspectives

edited by

Satohiro Masuda

submission deadline 31 Aug 2025 | Viewed by 84 | Submission Open

Keywords: G-protein-coupled receptors; membrane transporters; drug-metabolizing enzyme; endocytosis receptors; companion diagnostic (CDx); data science in pharmacogenomics; precision medicine with pharmacogenomics; siRNA; microRNA; drug-induced organ injury; drug-induced adverse reactions

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Techniques to Study Food Safety Challenges

edited by

María J. Andrade

and

Micaela Álvarez

submission deadline 31 Aug 2025 | Viewed by 84 | Submission Open

Keywords: food safety; hazards; foodborne pathogens; advanced microbial detection technologies; omics techniques; preventive measures

(This special issue belongs to the Section Molecular Microbiology)

From Pathogenic Mechanisms to Therapy in Retinal Diseases

edited by

Nan-Kai Wang

and

Eugene Yu Chuan Kang

submission deadline 31 Aug 2025 | Viewed by 79 | Submission Open

Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Cardiovascular Disease

edited by

John A. St. Cyr

submission deadline 31 Aug 2025 | Viewed by 79 | Submission Open

Keywords: myocardium; metabolism; ischemia; function; integrity; cardiovascular; disease; infarction; failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 31 Aug 2025 | Viewed by 78 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 31 Aug 2025 | Viewed by 78 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms

edited by

Dong-Sung Lee

and Chi-Su Yoon

submission deadline 31 Aug 2025 | Viewed by 77 | Submission Open

Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Focus on the Tryptophan Pathway

edited by

Burkhard Poeggeler

submission deadline 31 Aug 2025 | Viewed by 76 | Submission Open

Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan

(This special issue belongs to the Section Molecular Biology)

Cancer Progression and Therapeutic Resistance Mechanisms

edited by

Fabrizio Fontana

submission deadline 31 Aug 2025 | Viewed by 75 | Submission Open

Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds

(This special issue belongs to the Section Molecular Oncology)

New Advances in Plant Genetic Research

edited by

Ming Chen

submission deadline 31 Aug 2025 | Viewed by 73 | Submission Open

Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research Advances in Metabolic Syndrome

edited by

Phileno Pinge-Filho

submission deadline 31 Aug 2025 | Viewed by 73 | Submission Open

Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1151-1200 on page 24 of 68.

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