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Molecular Research of Cardiovascular Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 884

Special Issue Editor


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Guest Editor
Regulatory & Clinical Research Institute, University of Minnesota, Minneapolis, MN 55455, USA
Interests: cardiovascular surgery; congenital heart disease; heart failure; myocardial metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular disease remains the leading cause of death in men and women worldwide. Atherosclerosis, producing various degrees of vascular ischemia, is the most common type of cardiovascular disease. The heart's metabolism relies on adequate oxygenated blood flow to the myocardium to maintain its integrity and function. Various degrees of myocardial ischemia can negatively affect this state of myocardial homeostasis. Continued research efforts have led to the development of methods to lessen the negative effect of ischemia on the myocardium. This Special Issue is centered around the role of myocardial metabolism in cardiovascular disease.

Dr. John A. St. Cyr
Guest Editor

Manuscript Submission Information

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Keywords

  • myocardium
  • metabolism
  • ischemia
  • function
  • integrity
  • cardiovascular
  • disease
  • infarction
  • failure

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Published Papers (1 paper)

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Research

13 pages, 1259 KB  
Article
Platelet Apoptosis in Patients with Coronary Artery Disease Before and After CABG
by Arkadiy A. Metelkin, Ekaterina A. Sergeeva, Mikhail A. Popov, Dmitriy I. Zybin, Dmitriy V. Shumakov, Sergey G. Morozov and Alisa A. Sokolovskaya
Int. J. Mol. Sci. 2026, 27(7), 3304; https://doi.org/10.3390/ijms27073304 - 6 Apr 2026
Viewed by 526
Abstract
Cardiovascular diseases have been one of the leading causes of death worldwide for over 30 years and coronary artery disease occupies a prominent place among them. Predicting the long-term outcome after coronary artery bypass graft (CABG) is still a challenging task; however, since [...] Read more.
Cardiovascular diseases have been one of the leading causes of death worldwide for over 30 years and coronary artery disease occupies a prominent place among them. Predicting the long-term outcome after coronary artery bypass graft (CABG) is still a challenging task; however, since platelets are directly involved in the course of the disease, their functional status can help predict postoperative complications. The objective was to evaluate the dynamics of platelet apoptosis before and after CABG. The study involved 30 patients with a scheduled CABG suffering from coronary artery disease. Flow cytometry, Western blot and polymerase chain reaction were used to evaluate apoptosis and the activation of platelets. Changes in platelet membranes and the depolarization of mitochondrial membranes were observed, as well as the expression of active caspase 8 and BCL-2, indicating the activation of apoptosis through an extrinsic receptor-dependent signaling pathway. The data obtained suggest significant changes in platelet metabolic processes, which could play a crucial role in the development of coronary artery disease and atherosclerosis as well as being associated with postoperative complications. Full article
(This article belongs to the Special Issue Molecular Research of Cardiovascular Disease)
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