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Molecular Genetics and Genomics of Ruminants—Second Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 270

Special Issue Editor


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Guest Editor
USDA, ARS, Roman L. Hruska U.S. Meat Animal Research Center, Clay Center, NE 68933, USA
Interests: animal genomic architecture; sheep genetics and genomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ruminants play a huge role in economies throughout the world, converting forages into highly nutritious protein to feed an expanding worldwide population. The increased use of molecular genetics and genomics has enabled ruminant genetic improvement programs to achieve tremendous gains in production efficiency, improved animal health, and resilience and adaptability to different environmental production systems. Advances in technologies such as gene editing, sequencing technologies, and bioinformatics tool development have dramatically advanced our ability to analyze and understand genomes and the relationship between genotypes and phenotypes.

The purpose of this Special Issue is to report recent progress in genomics studies on ruminants. Possible topics include, but are not limited to, genetic and physical mapping, genome sequencing, genome structure and organization, genome assembly, comparative genomics, genome evolution, gene editing, expression profiling, host and rumen microbiome interactions, epigenomics, SNP discovery, genome-wide association studies, and genomic selection or prediction. Bioinformatics tools and databases that assist in genomic data analyses are also welcome.

Dr. Brad A. Freking
Guest Editor

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Keywords

  • ruminant genomics
  • structural genomics
  • functional genomics
  • epigenomics
  • gene expression
  • genome sequencing
  • genome evolution
  • genome-wide association study
  • genomic selection
  • marker-assisted selection

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Published Papers (1 paper)

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Research

14 pages, 1697 KiB  
Article
Characterisation of Four New Genes in the Ovine KAP19 Family
by Lingrong Bai, Huitong Zhou, Jianning He, Jinzhong Tao, Guo Yang and Jon G. H. Hickford
Int. J. Mol. Sci. 2025, 26(14), 6863; https://doi.org/10.3390/ijms26146863 - 17 Jul 2025
Viewed by 130
Abstract
This study identified four new keratin-associated protein genes (KRTAP19-n) in sheep: sKRTAP19-1, sKRTAP19-2, sKRTAP19-4, and sKRTAP19-6. These genes are closely related to the previously identified sheep genes KRTAP19-3 and KRTAP19-5, as well as to human KRTAP19-n [...] Read more.
This study identified four new keratin-associated protein genes (KRTAP19-n) in sheep: sKRTAP19-1, sKRTAP19-2, sKRTAP19-4, and sKRTAP19-6. These genes are closely related to the previously identified sheep genes KRTAP19-3 and KRTAP19-5, as well as to human KRTAP19-n genes. However, no clear orthologous relationships were found, suggesting complex evolutionary dynamics for this gene family. Extensive nucleotide sequence variation was observed across the four genes. sKRTAP19-1 had four variants, defined by four synonymous single-nucleotide polymorphisms (SNPs) and a variable number of “GGCTAC” hexanucleotide repeats. sKRTAP19-2 had five variants involving seven SNPs, three of which were non-synonymous. sKRTAP19-4 had five variants with nine SNPs (three being non-synonymous) and a three-nucleotide deletion. sKRTAP19-6 had eight variants, defined by 13 SNPs and a two-nucleotide consecutive substitution, with four of the SNPs being non-synonymous. One distinct variant each of sKRTAP19-4 and sKRTAP19-6 was found exclusively in Yanchi Tan sheep, with seven unique nucleotide differences compared to other variants. These unique variants were identical to the Romanov sheep genome in the region amplified (excluding the primer binding regions), suggesting a shared ancestral origin. The findings highlight considerable genetic diversity in ovine KRTAP19-n and lay a foundation for future research into their role in regulating wool fibre characteristics. Full article
(This article belongs to the Special Issue Molecular Genetics and Genomics of Ruminants—Second Edition)
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