ijms-logo

Journal Browser

Journal Browser

Innovative Applications of Topical Probiotics in Dermatology: Addressing Multiple Skin Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 563

Special Issue Editor


E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

We are delighted to invite you to contribute to the Special Issue "Innovative Applications of Topical Probiotics in Dermatology: Addressing Multiple Skin Disorders". This Special Issue aims to explore the cutting-edge molecular science behind the use of topical probiotics in dermatology, focusing on their potential to address various skin disorders.

The skin serves a fundamental role in maintaining homeostasis and providing a protective barrier against external factors. Recent scientific investigations have emphasized the therapeutic potential of probiotics and postbiotics in dermatological treatments and skincare. These bioactive microorganisms interact with the skin microbiota, modulate immune responses, and reinforce the skin barrier. Topical probiotics have emerged as a promising therapeutic option, and consequently, they represent a promising strategy for the management of various dermatological disorders, offering novel insights into skin microbiome modulation and its impact on skin health.

We invite you to contribute your expertise by submitting reviews and original articles that delve into the molecular mechanisms, clinical applications, and innovative research surrounding topical probiotics. Your contributions will help advance our understanding of how these probiotics can be harnessed to treat conditions such as acne, eczema, atopic dermatitis, psoriasis, and other dermatological issues.

We would like to acknowledge Dr. Lilian Sosa (Pharmaceutical Technology Research Group, Faculty of Chemical Sciences and Pharmacy, and Instituto de Investigaciones Microbiológicas (IIM), National Autonomous University of Honduras (UNAH), Tegucigalpa 11101, Honduras) for her participation as Guest Editor Assistant in the development of this Special Issue.

Dr. Mireia Mallandrich Miret
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • topical probiotics in dermatology
  • skin microbiome
  • skin disorders
  • therapeutic applications
  • molecular mechanisms

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

28 pages, 2553 KB  
Review
Topical Probiotics as a Novel Approach in the Treatment of Chronic Dermatoses Associated with Skin Dysbiosis: A Narrative Review
by Danuta Nowicka, Emilia Kucharczyk, Karolina Pawłuszkiewicz, Matylda Korgiel, Tomasz Busłowicz and Małgorzata Ponikowska
Int. J. Mol. Sci. 2025, 26(20), 10195; https://doi.org/10.3390/ijms262010195 - 20 Oct 2025
Viewed by 292
Abstract
The skin microbiome plays a pivotal role in maintaining skin homeostasis, immune regulation, and barrier integrity. Dysbiosis, characterized by altered diversity and function of the microflora, contributes to the pathogenesis of chronic inflammatory dermatoses such as atopic dermatitis, psoriasis, acne vulgaris, hidradenitis suppurativa, [...] Read more.
The skin microbiome plays a pivotal role in maintaining skin homeostasis, immune regulation, and barrier integrity. Dysbiosis, characterized by altered diversity and function of the microflora, contributes to the pathogenesis of chronic inflammatory dermatoses such as atopic dermatitis, psoriasis, acne vulgaris, hidradenitis suppurativa, rosacea, and photoaging. This narrative review, based on searches in PubMed, Scopus, and Google Scholar, summarizes current evidence on the role of topical probiotics in the prevention and management of inflammatory dermatoses, drawing mainly on studies from the past decade and, where relevant, earlier works published between 1975 and 2025. Evidence indicates that topical probiotics modulate local immune responses, enhance antimicrobial peptide synthesis, inhibit pathogenic microorganism colonization, and support skin barrier regeneration. Additional benefits include accelerated wound healing and reduced environmental damage. However, study results are heterogeneous, and designs vary, with limited data on long-term effects, particularly in paediatric and immunosuppressed populations. Topical probiotics are a promising therapeutic approach for chronic inflammatory dermatoses linked to microbiota dysbiosis. They can restore microbial balance, support barrier function, suppress pathogenic microorganisms, and promote skin regeneration. Despite consistent reports of clinical improvement and improved cutaneous defence mechanisms, small sample sizes, methodological heterogeneity, and the absence of standardized dosing regimens limit current evidence. Long-term safety data are limited, especially for vulnerable patient groups. Rigorous randomized controlled trials with standardized protocols and larger, diverse populations are needed to confirm efficacy, ensure safety, and guide clinical implementation. Full article
Show Figures

Figure 1

Back to TopTop