Advanced Molecular Research in Thromboinflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (25 February 2026) | Viewed by 1848
Special Issue Editor
Interests: anticoagulants; cardiovascular diseases; inflammation; thrombosis; venous thromboembolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In general, thromboinflammation refers to increased inflammation resulting from a thrombotic process. Initially, this term was used to describe the interaction between platelets and leukocytes, but it’s definition has since been extended to represent the strict relationship of platelets and coagulation factors with immune cells, endothelium, or complement systems. Activated platelets may favor leukocytes recruitment and differentiation into proinflammatory subtypes, oxidative stress development, and cytokine production. They may also affect the clearance of pathogens by increasing their phagocytosis and antibody production. Regarding coagulation cascades, coagulation factors may alter leukocyte trafficking and endothelial permeability, further interfering with inflammatory processes.
Despite the fact that several mechanisms of thromboinflammation have been identified over the last few years, our understanding of how the hemostatic system influences inflammatory and immune responses remains limited. Therefore, the aim of this Special Issue is to advance our knowledge of molecular pathways of thromboinflammation.
Dr. Emanuele Valeriani
Guest Editor
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Keywords
- blood coagulation factors
- blood platelets
- endothelium
- inflammation
- thromboinflammation
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