Cell Fate Decisions: Autophagy, Apoptosis, Pyroptosis, Necroptosis, Ferroptosis and PANoptosis in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1005
Special Issue Editor
Special Issue Information
Dear Colleagues,
The decisions that govern cellular life and death play a crucial role in maintaining homeostasis and shaping the pathological landscape of diseases. Genetic programs and regulatory networks driving cell survival and death are fundamental for understanding human biology and developing novel therapeutics. Recent advancements in regulated cell death pathways have highlighted the unique characteristics of distinct cell death modalities. While apoptotic cell death is largely non-immunogenic, forms like pyroptosis, necroptosis, and PANoptosis are predominantly pro-inflammatory. The immunomodulatory potential of ferroptosis is still being unraveled, offering exciting new avenues for research. Autophagy, traditionally viewed as a protective mechanism antagonizing several cell death pathways and inflammation, can also paradoxically promote cell death under certain conditions.
Given the intricate links between cell death and survival pathways, mutations in the genes regulating these processes often lead to developmental defects in animals and immune deficiencies or autoinflammatory diseases in humans. Thus, novel phenotypic observations and further mechanistic insights into this fundamental cellular decision network will be the key to innovative therapeutic strategies and a better understanding of health and disease.
In this Special Issue, “Cell Fate Decisions: Autophagy, Apoptosis, Pyroptosis, Necroptosis, Ferroptosis and PANoptosis in Health and Disease”, we invite original research articles and thought-provoking reviews that reveal novel phenotypes, explore the mechanisms initiating, mediating, executing, or antagonizing cell death in different cell types and across diverse pathophysiological settings. We aim to be conceptually inspiring and advance the field toward novel, interesting and impactful discoveries.
Dr. Yaqiu Wang
Guest Editor
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Keywords
- inflammation
- autophagy
- apoptosis
- pyroptosis
- necroptosis
- PANoptosis
- ferroptosis
- cell death
- cell survival
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