Immune Regulation in Lung Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 918
Special Issue Editors
Interests: inflammasome; immunology; lung cancer
Special Issues, Collections and Topics in MDPI journals
Interests: immunotherapy and target therapy; cancer; inflammation; immunity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The lung is constantly exposed to a plethora of threats, which can induce infection, inflammation or tissue injury, paving the way for the establishment of lung diseases, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma and, even worse, cancer. Under physiological conditions, the airways are protected against pathogens and irritants by innate and adaptive immunity cells, which in association with structural cells orchestrate lung immunity to minimize lung disease and ensure a balanced response, thus avoiding excessive inflammatory reactions and subsequent lung tissue damage. Thus, the key role of immune regulation in either the resolution or establishment of lung disease appears clear. In this context, the intercellular communication between the epithelial and immune cells is facilitated by lipid mediators, cytokines and chemokines, which in turn promote the attraction of various immune cellular populations to shape lung microenvironment. In this context, a better understanding of the complexity and dynamicity of the lung immune system, especially through multi-omics and computational approaches, is pivotal in order to determine how respiratory immunity interacts with other complex networks in pathological conditions and to provide a basis for the selection of novel therapeutic strategies against lung diseases. Overall, the elucidation of immune regulation in lung disease could contribute to the development of tailored interventions for optimizing therapeutic outcomes in respiratory disease management.
Dr. Chiara Colarusso
Dr. Rosalinda Sorrentino
Guest Editors
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Keywords
- lung disease
- immune system
- lung immune cells
- lung epithelial cells
- therapy
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