Cellular and Molecular Mechanisms of Cardiovascular Repair
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 4722
Special Issue Editor
Interests: cardiac microenvironment; cardiac repair mechanisms; 3D culture
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are delighted to introduce this Special Issue of IJMS which explores the intricate processes governing cardiovascular repair and regeneration. This collection aims at highlighting the key roles of defence and repair cell types, such as immune cells and fibroblasts, in injury mending, emphasizing their contribution to cardiac scar formation and remodeling, as well as other accessory mechanisms such as new vessel formation. Furthermore, we will try to provide novel insights into the dynamics of the extracellular matrix (ECM) within physiopathological conditions and elucidate its critical function in supporting tissue structure and inter-cellular communication during fibrosis and healing. Additionally, this Special Issue aims at exploring the mechanisms of fibrosis and its intertwined relationship with inflammation, offering a comprehensive understanding of its impact on cardiovascular function post-injury. We seek contributions also examining angiogenesis, as a vital process in restoring oxygen supply and promoting tissue recovery. By integrating all these key aspects, our collection will provide a holistic view of cardiovascular repair, aiming to advance physiopathology comprehension, as well as suggesting novel therapeutic strategies for cardiovascular diseases. We aim to attract the attention of both researchers and clinicians dedicated to translational cardiovascular reseach and advancing cardiovascular medicine.
Suitable topics include, but are not limited to, the following:
- Role of different cell types in cardiovascular repair mechanisms;
- Interplay between inflammation and fibrosis;
- Mechanisms of cardio-protection;
- Angiogenesis in cardiovascular repair;
- Novel therapeutic targets or strategies.
Dr. Isotta Chimenti
Guest Editor
Manuscript Submission Information
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Keywords
- fibroblasts
- injury repair
- cardiac scar
- extracellular matrix
- fibrosis
- angiogenesis
- inflammation
- cardioprotection
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